diff --git a/src/agents/realtime/session.py b/src/agents/realtime/session.py
index 8b3b10936..4629f1bb5 100644
--- a/src/agents/realtime/session.py
+++ b/src/agents/realtime/session.py
@@ -98,7 +98,7 @@ def __init__(
         self._stored_exception: Exception | None = None
 
         # Guardrails state tracking
-        self._interrupted_by_guardrail = False
+        self._interrupted_response_ids: set[str] = set()
         self._item_transcripts: dict[str, str] = {}  # item_id -> accumulated transcript
         self._item_guardrail_run_counts: dict[str, int] = {}  # item_id -> run count
         self._debounce_text_length = self._run_config.get("guardrails_settings", {}).get(
@@ -242,7 +242,8 @@ async def on_event(self, event: RealtimeModelEvent) -> None:
 
             if current_length >= next_run_threshold:
                 self._item_guardrail_run_counts[item_id] += 1
-                self._enqueue_guardrail_task(self._item_transcripts[item_id])
+                # Pass response_id so we can ensure only a single interrupt per response
+                self._enqueue_guardrail_task(self._item_transcripts[item_id], event.response_id)
         elif event.type == "item_updated":
             is_new = not any(item.item_id == event.item.item_id for item in self._history)
             self._history = self._get_new_history(self._history, event.item)
@@ -274,7 +275,6 @@ async def on_event(self, event: RealtimeModelEvent) -> None:
             # Clear guardrail state for next turn
             self._item_transcripts.clear()
             self._item_guardrail_run_counts.clear()
-            self._interrupted_by_guardrail = False
 
             await self._put_event(
                 RealtimeAgentEndEvent(
@@ -442,7 +442,7 @@ def _get_new_history(
         # Otherwise, add it to the end
         return old_history + [event]
 
-    async def _run_output_guardrails(self, text: str) -> bool:
+    async def _run_output_guardrails(self, text: str, response_id: str) -> bool:
         """Run output guardrails on the given text. Returns True if any guardrail was triggered."""
         combined_guardrails = self._current_agent.output_guardrails + self._run_config.get(
             "output_guardrails", []
@@ -455,7 +455,8 @@ async def _run_output_guardrails(self, text: str) -> bool:
                 output_guardrails.append(guardrail)
                 seen_ids.add(guardrail_id)
 
-        if not output_guardrails or self._interrupted_by_guardrail:
+        # If we've already interrupted this response, skip
+        if not output_guardrails or response_id in self._interrupted_response_ids:
             return False
 
         triggered_results = []
@@ -475,8 +476,12 @@ async def _run_output_guardrails(self, text: str) -> bool:
                 continue
 
         if triggered_results:
-            # Mark as interrupted to prevent multiple interrupts
-            self._interrupted_by_guardrail = True
+            # Double-check: bail if already interrupted for this response
+            if response_id in self._interrupted_response_ids:
+                return False
+
+            # Mark as interrupted immediately (before any awaits) to minimize race window
+            self._interrupted_response_ids.add(response_id)
 
             # Emit guardrail tripped event
             await self._put_event(
@@ -502,10 +507,10 @@ async def _run_output_guardrails(self, text: str) -> bool:
 
         return False
 
-    def _enqueue_guardrail_task(self, text: str) -> None:
+    def _enqueue_guardrail_task(self, text: str, response_id: str) -> None:
         # Runs the guardrails in a separate task to avoid blocking the main loop
 
-        task = asyncio.create_task(self._run_output_guardrails(text))
+        task = asyncio.create_task(self._run_output_guardrails(text, response_id))
         self._guardrail_tasks.add(task)
 
         # Add callback to remove completed tasks and handle exceptions
diff --git a/tests/realtime/test_session.py b/tests/realtime/test_session.py
index e5d2d5d45..3b6c5bac6 100644
--- a/tests/realtime/test_session.py
+++ b/tests/realtime/test_session.py
@@ -1050,7 +1050,6 @@ async def test_transcript_delta_triggers_guardrail_at_threshold(
         await self._wait_for_guardrail_tasks(session)
 
         # Should have triggered guardrail and interrupted
-        assert session._interrupted_by_guardrail is True
         assert mock_model.interrupts_called == 1
         assert len(mock_model.sent_messages) == 1
         assert "triggered_guardrail" in mock_model.sent_messages[0]
@@ -1187,14 +1186,12 @@ async def test_turn_ended_clears_guardrail_state(
         # Wait for async guardrail tasks to complete
         await self._wait_for_guardrail_tasks(session)
 
-        assert session._interrupted_by_guardrail is True
         assert len(session._item_transcripts) == 1
 
         # End turn
         await session.on_event(RealtimeModelTurnEndedEvent())
 
         # State should be cleared
-        assert session._interrupted_by_guardrail is False
         assert len(session._item_transcripts) == 0
         assert len(session._item_guardrail_run_counts) == 0
 
@@ -1259,7 +1256,6 @@ async def test_agent_output_guardrails_triggered(self, mock_model, triggered_gua
         await session.on_event(transcript_event)
         await self._wait_for_guardrail_tasks(session)
 
-        assert session._interrupted_by_guardrail is True
         assert mock_model.interrupts_called == 1
         assert len(mock_model.sent_messages) == 1
         assert "triggered_guardrail" in mock_model.sent_messages[0]
@@ -1272,6 +1268,63 @@ async def test_agent_output_guardrails_triggered(self, mock_model, triggered_gua
         assert len(guardrail_events) == 1
         assert guardrail_events[0].message == "this is more than ten characters"
 
+    @pytest.mark.asyncio
+    async def test_concurrent_guardrail_tasks_interrupt_once_per_response(self, mock_model):
+        """Even if multiple guardrail tasks trigger concurrently for the same response_id,
+        only the first should interrupt and send a message."""
+        import asyncio
+
+        # Barrier to release both guardrail tasks at the same time
+        start_event = asyncio.Event()
+
+        async def async_trigger_guardrail(context, agent, output):
+            await start_event.wait()
+            return GuardrailFunctionOutput(
+                output_info={"reason": "concurrent"}, tripwire_triggered=True
+            )
+
+        concurrent_guardrail = OutputGuardrail(
+            guardrail_function=async_trigger_guardrail, name="concurrent_trigger"
+        )
+
+        run_config: RealtimeRunConfig = {
+            "output_guardrails": [concurrent_guardrail],
+            "guardrails_settings": {"debounce_text_length": 5},
+        }
+
+        # Use a minimal agent (guardrails from run_config)
+        agent = RealtimeAgent(name="agent")
+        session = RealtimeSession(mock_model, agent, None, run_config=run_config)
+
+        # Two deltas for same item and response to enqueue two guardrail tasks
+        await session.on_event(
+            RealtimeModelTranscriptDeltaEvent(
+                item_id="item_1", delta="12345", response_id="resp_same"
+            )
+        )
+        await session.on_event(
+            RealtimeModelTranscriptDeltaEvent(
+                item_id="item_1", delta="67890", response_id="resp_same"
+            )
+        )
+
+        # Wait until both tasks are enqueued
+        for _ in range(50):
+            if len(session._guardrail_tasks) >= 2:
+                break
+            await asyncio.sleep(0.01)
+
+        # Release both tasks concurrently
+        start_event.set()
+
+        # Wait for completion
+        if session._guardrail_tasks:
+            await asyncio.gather(*session._guardrail_tasks, return_exceptions=True)
+
+        # Only one interrupt and one message should be sent
+        assert mock_model.interrupts_called == 1
+        assert len(mock_model.sent_messages) == 1
+
 
 class TestModelSettingsIntegration:
     """Test suite for model settings integration in RealtimeSession."""