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| 51 | + <header class="jumbotron subhead" id="overview"> |
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| 54 | + <h1>OpenWorm News</h1> |
| 55 | + <p class="lead"> |
| 56 | + Recent updates from the OpenWorm project |
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| 66 | + <li> |
| 67 | + <a href="#September2022"><i class="fa fa-chevron-right"></i> September 2022</a> |
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| 73 | + <div class="span9"> |
| 74 | + |
| 75 | + <section id="September2022"> |
| 76 | + <div class="page-header"> |
| 77 | +<h1>September 2022</h1> |
| 78 | + |
| 79 | +<h3>1) OpenCollective as a new funding stream</h3> |
| 80 | + |
| 81 | +<p align="center"><img src="https://raw.githubusercontent.com/openworm/Newsletter/main/img/opencollective.png" alt="OpenWorm" width="400"/></p> |
| 82 | + |
| 83 | +<p class="lead">We have added <a href="https://opencollective.com/openworm">OpenCollective</a> as a new and easy way to donate to OpenWorm. |
| 84 | + Regular contributions to the project (monthly/yearly) are possible through this funding stream. |
| 85 | + See <a href="https://openworm.org/donate">here</a> for more details.</p> |
| 86 | + |
| 87 | +<p class="lead">One of the first uses of these funds will be to support <b>OpenWorm Studentships</b> (see below).</p> |
| 88 | + |
| 89 | + |
| 90 | +<h3>2) OpenWorm Studentships - first successful project completed</h3> |
| 91 | + |
| 92 | +<p class="lead">OpenWorm Studentships are a new way to incentivize contribution to the OpenWorm project, |
| 93 | + offering small stipends and recognition to junior researchers who want to spend time bringing their research |
| 94 | + into OpenWorm and making it more accessible for the wider community. See |
| 95 | + <a href="https://openworm.org/studentships.html">here</a> for more information.</p> |
| 96 | + |
| 97 | +<p class="lead">The first person to complete an OpenWorm Studentship project has been <b>Tyson Wheelwright</b>. He has made significant updates to |
| 98 | + the <a href="https://github.com/openworm/Blender2NeuroML/">Blender 2 NeuroML</a> subproject.</p> |
| 99 | + |
| 100 | +<p align="center"><img src="https://github.com/openworm/Blender2NeuroML/raw/master/images/Blender_ADAL.png" width="400"/> |
| 101 | +<img src="https://github.com/openworm/Blender2NeuroML/raw/master/images/ADAL.png" width="400"/></p> |
| 102 | +<p align="center"><i>Figure showing a single cell (<a href="https://www.wormatlas.org/neurons/Individual%20Neurons/ADAframeset.html">ADAL</a>) highlighted in orange in the original |
| 103 | +<a href="https://github.com/openworm/Blender2NeuroML/blob/master/src/Data/Virtual_Worm_March_2011.blend">3D Blender file</a> (from the |
| 104 | +<a href="http://caltech.wormbase.org/virtualworm">Virtual Worm Project</a>) on the left, and corresponding images of the cell on its own in Blender (middle 2 panels) and in |
| 105 | +<a href="https://docs.neuroml.org/Userdocs/NeuroMLv2.html">NeuroML 2</a> format (right 2 panels). The NeuroML version is being used in our |
| 106 | +<a href="https://github.com/openworm/c302">biophysical model of the worm nervous system</a>. See |
| 107 | +<a href="https://github.com/openworm/Blender2NeuroML/blob/master/src/NeuroMLImages/README.md">here</a> for more examples.</i></p> |
| 108 | + |
| 109 | +<p class="lead">More Studentships will be offered to the community in late 2022.</p> |
| 110 | + |
| 111 | + |
| 112 | +<h3>3) NeuroPAL</h3> |
| 113 | + |
| 114 | +<p class="lead">The recent paper <a href="https://www.sciencedirect.com/science/article/pii/S0092867420316822">NeuroPAL: A Multicolor Atlas for Whole-Brain Neuronal Identification in <i>C. elegans</i></a> described a groundbreaking new technique to create a genetic strain of the worm where each neuron |
| 115 | +is labelled with a fluorescent marker of a specific color, allowing easy identification of neurons across experiments and animals.</p> |
| 116 | + |
| 117 | +<p class="lead">We have converted one of these datasets containing positions of cell bodies and the expressed NeuroPAL colors to NeuroML, |
| 118 | + to allow it to be used in OpenWorm models and associated applications. Full details can be found |
| 119 | + <a href="https://github.com/openworm/NeuroPAL">here</a>.</p> |
| 120 | + |
| 121 | +<p align="center"><kbd><img src="https://raw.githubusercontent.com/openworm/NeuroPAL/main/NeuroML2/Screenshot_Canonical.png" alt="NeuroPAL" width="550"></kbd></p> |
| 122 | + |
| 123 | +<p align="center"><i>The above image shows the canonical positions and colors of a NeuroPAL dataset which has been <a href="https://github.com/openworm/NeuroPAL/tree/main/NeuroML2">converted into NeuroML</a>, allowing it to be <a href="https://www.opensourcebrain.org/projects/neuropal/repository/revisions/main/show/NeuroML2?explorer=https%253A%252F%252Fraw.githubusercontent.com%252Fopenworm%252FNeuroPAL%252Fmain%252FNeuroML2%252FNeuroPAL_Canonical.net.nml">visualised on Open Source Brain</a>.</i></p> |
| 124 | + |
| 125 | + |
| 126 | +<h3>4) Electrophysiological data from worm neurons</h3> |
| 127 | + |
| 128 | +<p class="lead">Electrical recordings from individual neurons in <i>C. elegans</i> are crucial experimental data required for |
| 129 | + creating biologically realistic computational models of the worm.</p> |
| 130 | + |
| 131 | +<p class="lead">Electrophysiological recordings of the activity of the |
| 132 | + <a href="https://www.wormatlas.org/neurons/Individual%20Neurons/ASHframeset.html">ASH neuron</a> made by the |
| 133 | + <a href="https://med.stanford.edu/goodmanlab.html">Wormsense Lab</a> of Miriam Goodman were converted to open, standardized |
| 134 | + <a href="http://nwb.org">Neurodata Without Borders</a> format as part of a |
| 135 | + <a href="https://summerofcode.withgoogle.com/">Google Summer of Code</a> project in 2021 by Steph Prince. Further details, |
| 136 | + as well as all of the converted datasets, can be found |
| 137 | + <a href="https://github.com/openworm/WormsenseLab_ASH">here</a>.</p> |
| 138 | + |
| 139 | +<p align="center"><img src="https://raw.githubusercontent.com/openworm/WormsenseLab_ASH/main/images/example_goodman_lab_file.png" width=600/></p> |
| 140 | +<p align="center"><i>A view of the |
| 141 | +<a href="http://nwbexplorer.opensourcebrain.org/">NWB Explorer</a> interface showing one of the converted electrophysiological datasets. Click |
| 142 | +<a href="https://github.com/openworm/WormsenseLab_ASH/blob/main/test_data/README.md">here</a> to explore other datasets and get direct |
| 143 | +links to NWB Explorer to browse them.</i></p> |
| 144 | + |
| 145 | + |
| 146 | +<h3>5) DevoWorm updates</h3> |
| 147 | + |
| 148 | +<p align="center"><img src="https://raw.githubusercontent.com/OREL-group/GSoC/main/Media/DW.png" height="150"/></p> |
| 149 | + |
| 150 | +<p class="lead">Over the past year, <a href="https://devoworm.weebly.com/">DevoWorm</a> has been involved in a number of initiatives. |
| 151 | + DevoWorm hosted four <a href="https://summerofcode.withgoogle.com/">Google Summer of Code</a> students in 2022: Karan Lohaan and Harikrishna |
| 152 | + Pillai worked on the Digital Microspheres project (a spherical platform for embryo data), while Jiahang Li and Wataru Kawakami worked |
| 153 | + on developing a Graph Neural Network pipeline for the DevoLearn platform.</p> |
| 154 | + |
| 155 | +<p class="lead">DevoWorm also had a presence at <a href="https://netsci2022.net/">NetSci 2022</a> (virtual conference hosted in Shanghai). |
| 156 | + Bradly Alicea presented on the group's Embodied Hypernetworks work in the main conference, as well as serving to represent the group |
| 157 | + at the Network Neuroscience satellite session as a presenter and participant.</p> |
| 158 | + |
| 159 | +<p class="lead">Our <a href="https://www.youtube.com/playlist?list=PLJ8ZcBZeKeci2ACwfllCDFn_eZAXlbGQN">weekly meetings</a> are a continuing success. |
| 160 | + We cover a number of technical topics and a wide variety of topical reviews spanning biophysics, developmental biology, computational |
| 161 | + analysis, and more. Join us on Mondays at 2pm UTC (1pm UTC in winter) to get involved.</p> |
| 162 | + |
| 163 | +<h3>6) OpenWorm simulation stack updates</h3> |
| 164 | + |
| 165 | +<p align="center"><img src="https://raw.githubusercontent.com/openworm/OpenWorm/master/img/worm-crawling.gif" alt="Worm Crawling" width="550"></p> |
| 166 | +<p align="center"><i>Example movie generated when the Docker container containing the OpenWorm simulation stack runs for 5 |
| 167 | + seconds of simulated time.</i></p> |
| 168 | + |
| 169 | +<p class="lead">We have made a new release of the |
| 170 | + <a href="https://hub.docker.com/r/openworm/openworm">Docker container</a> that pulls together |
| 171 | + the major components of our simulation stack and allows it to be run on your machine. It includes |
| 172 | + <a href="https://github.com/openworm/sibernetic">Sibernetic</a>, |
| 173 | + <a href="https://github.com/openworm/c302">c302</a> and |
| 174 | + <a href="https://github.com/openworm/owmeta">owmeta</a>. |
| 175 | + See details <a href="https://github.com/openworm/OpenWorm/blob/master/README.md#quickstart">here</a>.</p> |
| 176 | + |
| 177 | +<h3>7) Other announcements</h3> |
| 178 | + |
| 179 | +<p align="center"><kbd><a href="docs/OpenWormPoster_C_elegans_meeting_June_2021.pdf"> |
| 180 | + <img src="https://raw.githubusercontent.com/openworm/Newsletter/main/img/OpenWormPoster2022.png" alt="OpenWormPoster2022" width="450"></a></kbd></p> |
| 181 | + |
| 182 | +<p class="lead">A poster presenting the latest status of the OpenWorm project was presented at the |
| 183 | + <a href="https://genetics-gsa.org/celegans-2021/">main global |
| 184 | + conference in the <i>C. elegans</i> field</a> in June 2021. Click on the image above to download the poster.</p> |
| 185 | + |
| 186 | + |
| 187 | + |
| 188 | + |
| 189 | + |
| 190 | + |
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