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Merge pull request #180 from openworm/development
Just some italics on C. elegans
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science.html

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<!--<div class="openworm_logo_header"></div>-->
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<h1>OpenWorm Science</h1>
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<p class="lead">
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Resources OpenWorm has developed for the C. elegans research community.
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Resources OpenWorm has developed for the <i>C. elegans</i> research community.
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</p>
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</div>
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</header>
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<h1>OpenWorm for Scientists</h1>
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</div>
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<p class="lead">
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OpenWorm is an open source project dedicated to creating the world’s first virtual organism in a computer, a C.elegans nematode.
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Throughout the years we have built a network of relationships with with many biologists and neuroscientists interested in C. elegans.
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OpenWorm is an open source project dedicated to creating the world’s first virtual organism in a computer, a <i>C. elegans</i> nematode.
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Throughout the years we have built a network of relationships with with many biologists and neuroscientists interested in <i>C. elegans</i>.
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This page presents the scientific data and resources produced by the OpenWorm community for the benefit of experimental and
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computational scientists working in this area.
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</p>
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<h3>Existing Scientific Collaborations</h3>
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<p class="lead">
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The entire C. elegans experimental community that assembles at the yearly
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<a href="http://www.genetics-gsa.org/conferences/Celegans_meeting.shtml" target="_blank">GSA C. elegans meeting</a>
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is incredibly welcoming and supportive. We've received data and help from C. elegans biologists including
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The entire <i>C. elegans</i> experimental community that assembles at the yearly
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<a href="http://www.genetics-gsa.org/conferences/Celegans_meeting.shtml" target="_blank">GSA <i>C. elegans</i> meeting</a>
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is incredibly welcoming and supportive. We've received data and help from <i>C. elegans</i> biologists including
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<a href="http://www.salk.edu/faculty/chalasani.html" target="_blank">Dr. Sreekanth Chalasani</a> at the Salk Institute,
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<a href="https://www.linkedin.com/in/michael-francis-666220122" target="_blank">Dr. Michael Francis</a> at UMass Medical School,
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<a href="http://www2.mrc-lmb.cam.ac.uk/groups/wschafer" target="_blank">Dr. William Schafer</a> at University of Cambridge
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<h1>OpenWorm Resources</h1>
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</div>
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<p class="lead">
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The OpenWorm project has produced various resources to make it easier to explore the anatomy of the C.elegans, and has released
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The OpenWorm project has produced various resources to make it easier to explore the anatomy of the <i>C. elegans</i>, and has released
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early versions of applications which will enable the biophysical simulation of the worm and its interactions with its environment.
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</p>
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<h3>OpenWorm Documentation</h3>
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<img src="./img/sci_browser.png" alt="">
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<br/><br/>
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<p class="lead">
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The OpenWorm browser exposes through a web interface the anatomical model of C.elegans
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The OpenWorm browser exposes through a web interface the anatomical model of <i>C. elegans</i>
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developed as part of the <a href="http://caltech.wormbase.org/virtualworm/" target="_blank">Virtual Worm project at Caltech</a>. The application allows
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pealing different layers of the worm revealing distinct groups for the nervous system,
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the muscle cells, the organs and the cuticle. All the cells of the worm are searchable
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<br/>
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<a href="https://itunes.apple.com/us/app/openworm-browser/id595581306?mt=8" target="_blank">OpenWorm Browser iOS</a>
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</p>
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<h3>NeuroML C.elegans Connectome</h3>
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<h3>NeuroML <i>C. elegans</i> Connectome</h3>
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<br/>
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<img src="./img/sci_neuroml.png" alt="" width="500">
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<br/><br/>
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<p class="lead">
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The team has produced a model of the connectome of the C.elegans in <a href="http://neuroml.org/" target="_blank">NeuroML</a>,
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The team has produced a model of the connectome of the <i>C. elegans</i> in <a href="http://neuroml.org/" target="_blank">NeuroML</a>,
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a standard for describing computational models of neurons and networks.
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The model has been generated by post-processing the morphology of the nervous
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system available in the Blender file produced by the Virtual Worm project with
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3D through Open Source Brain; OSB Explorer allows scientists to expose the property
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of the neurons and navigate their connections by simply clicking on them.
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<br/><br/>
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<a href="http://opensourcebrain.org/projects/celegans?explorer=https%3A%2F%2Fraw.github.com%2Fopenworm%2FCElegansNeuroML%2Fmaster%2FCElegans%2FgeneratedNeuroML2%2FMuscleCellConnections.net.nml" target="_blank">C.elegans connectome on Open Source Brain</a>
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<a href="http://opensourcebrain.org/projects/celegans?explorer=https%3A%2F%2Fraw.github.com%2Fopenworm%2FCElegansNeuroML%2Fmaster%2FCElegans%2FgeneratedNeuroML2%2FMuscleCellConnections.net.nml" target="_blank"><i>C. elegans</i> connectome on Open Source Brain</a>
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</p>
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<h3>Sibernetic</h3>
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<br/>
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Openworm has been developing <a href="http://openworm.github.io/sibernetic/" target="_blank">Sibernetic</a>, a C++ implementation of the Predictive-corrective
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Incompressible Smooth Particle Hydrodynamics (PCI-SPH) algorithm based on the work of <a href="https://sph-sjtu-f06.googlecode.com/files/a40-solenthaler.pdf" target="_blank">Solenthaler</a>.
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The algorithm has been extended to model contractile matter and membranes for simulating
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the muscle tissue of the C. elegans. The implementation uses OpenCL to distribute the computation
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the muscle tissue of the <i>C. elegans</i>. The implementation uses OpenCL to distribute the computation
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of the particle system on both CPUs and GPUs in a parallelized way.
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<br/><br/>
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<a href="https://github.com/openworm/Smoothed-Particle-Hydrodynamics" target="_blank">Sibernetic sources</a><br/>
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<h1>External Resources</h1>
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</div>
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<p class="lead">
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This is a list of online resources related to C. elegans which we have found useful in the OpenWorm project.
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This is a list of online resources related to <i>C. elegans</i> which we have found useful in the OpenWorm project.
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If you know of other resources we should include here, please <a href="contacts.html">get in contact</a>!
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</p>
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<table class="table">
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</thead>
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<tbody>
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<tr>
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<td class="lead"><a href="https://docs.google.com/a/metacell.us/spreadsheet/ccc?key=0ArNOKkIblIRadE5lVkN4WGMzNUZLdVROUEZVTUlUVGc&usp=drive_web#gid=0" target="_blank">C. Elegans Ion Channels</a></td>
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<td class="lead"><a href="https://docs.google.com/a/metacell.us/spreadsheet/ccc?key=0ArNOKkIblIRadE5lVkN4WGMzNUZLdVROUEZVTUlUVGc&usp=drive_web#gid=0" target="_blank"><i>C. elegans</i> Ion Channels</a></td>
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<td class="lead">Spreadsheet of ion channels</td>
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</tr>
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<tr>
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</tr>
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<tr>
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<td class="lead"><a href="http://www.wormbase.org/" target="_blank">WormBase</a></td>
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<td class="lead">A comprehensive web-based database of genes, gene expression, proteins, and much more specifically for c. elegans and related species</td>
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<td class="lead">A comprehensive web-based database of genes, gene expression, proteins, and much more specifically for <i>C. elegans</i> and related species</td>
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</tr>
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<td class="lead"><a href="http://caltech.wormbase.org/virtualworm/" target="_blank">Virtual Worm project at WormBase</a></td>
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<td class="lead">3D Blender files for the anatomy of the C. elegans</td>
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<td class="lead">3D Blender files for the anatomy of the <i>C. elegans</i></td>
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</tr>
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<tr>
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<td class="lead"><a href="http://www.ncbi.nlm.nih.gov/books/NBK19997/" target="_blank">C. elegans II</a></td>
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<td class="lead">Web-based textbook for all things C. elegans. Second edition</td>
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<td class="lead"><a href="http://www.ncbi.nlm.nih.gov/books/NBK19997/" target="_blank"><i>C. elegans</i> II</a></td>
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<td class="lead">Web-based textbook for all things <i>C. elegans</i>. Second edition</td>
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</tr>
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<td class="lead"><a href="http://www.wormbook.org/" target="_blank">WormBook</a></td>
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</tr>
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<td class="lead"><a href="http://www.rnai.org/" target="_blank">RNAiDB</a></td>
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<td class="lead">Provides access to results from RNAi interference studies in C. elegans, including images, movies, phenotypes, and graphical maps</td>
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<td class="lead">Provides access to results from RNAi interference studies in <i>C. elegans</i>, including images, movies, phenotypes, and graphical maps</td>
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</tr>
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<td class="lead"><a href="http://www.worm.mpi-cbg.de/phenobank/cgi-bin/MenuPage.py" target="_blank">PhenoBank</a></td>
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<td class="lead">Our aim was to test all C. elegans genes for their role in the first two rounds of mitotic cell division. To this end, we combined genome-wide RNAi screening with time-lapse video microscopy of the early embryo</td>
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<td class="lead">Our aim was to test all <i>C. elegans</i> genes for their role in the first two rounds of mitotic cell division. To this end, we combined genome-wide RNAi screening with time-lapse video microscopy of the early embryo</td>
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</tr>
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<td class="lead"><a href="http://interactome.dfci.harvard.edu/C_elegans/" target="_blank">Worm Interactome DB</a></td>
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<td class="lead">Worm Interactome version 8 assembles high-quality yeast two-hybrid protein protein interactions in C. elegans</td>
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<td class="lead">Worm Interactome version 8 assembles high-quality yeast two-hybrid protein protein interactions in <i>C. elegans</i></td>
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<td class="lead"><a href="http://www.ebi.ac.uk/intact/main.xhtml" target="_blank">IntAct</a></td>
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</tr>
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<td class="lead"><a href="http://bgypc059.leeds.ac.uk/~web/databaseintro.htm" target="_blank">Hope Laboratory Expression Pattern Database</a></td>
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<td class="lead">Each page in this database is a record of the results of one experiment. For each experiment, a C. elegans genomic DNA fragment has been joined to a reporter gene, either lacZ or gfp and this fusion gene has been used to generate transgenic C. elegans lines</td>
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<td class="lead">Each page in this database is a record of the results of one experiment. For each experiment, a <i>C. elegans</i> genomic DNA fragment has been joined to a reporter gene, either lacZ or gfp and this fusion gene has been used to generate transgenic <i>C. elegans</i> lines</td>
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<td class="lead"><a href="http://gfpweb.aecom.yu.edu/index" target="_blank">BC C. elegans Gene Expression Consortium</a></td>
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<td class="lead">Expression patterns for C. elegans promoter:GFP fusions</td>
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<td class="lead"><a href="http://gfpweb.aecom.yu.edu/index" target="_blank">BC <i>C. elegans</i> Gene Expression Consortium</a></td>
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<td class="lead">Expression patterns for <i>C. elegans</i> promoter:GFP fusions</td>
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<td class="lead"><a href="http://smd.princeton.edu/" target="_blank">Stanford Microarray Database</a></td>
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<td class="lead"><a href="http://forums.wormbase.org/" target="_blank">Worm Community Forums</a></td>
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<td class="lead">Forums for discussing scientific topics with c. elegans scientists</td>
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<td class="lead">Forums for discussing scientific topics with <i>C. elegans</i> scientists</td>
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</tr>
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<td class="lead"><a href="http://www.ncbi.nlm.nih.gov/gene" target="_blank">Entrez Gene</a></td>
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<td class="lead">Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide</td>
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<td class="lead"><a href="http://www.ncbi.nlm.nih.gov/mapview/map_search.cgi?taxid=6239" target="_blank">MapViewer</a></td>
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<td class="lead">The 100 Mb genome is organized in six chromosomes and annotation represents more than 20,000 genes. The gene, transcript, and protein annotation is provided by WormBase and NCBI provides ab initio model predictions and calculates alignments to provide the C. elegans UniGene (Cel_UniG) and transcript (Cel_EST) maps</td>
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<td class="lead">The 100 Mb genome is organized in six chromosomes and annotation represents more than 20,000 genes. The gene, transcript, and protein annotation is provided by WormBase and NCBI provides ab initio model predictions and calculates alignments to provide the <i>C. elegans</i> UniGene (Cel_UniG) and transcript (Cel_EST) maps</td>
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<td class="lead"><a href="http://www.ensembl.org/Caenorhabditis_elegans/Info/Index" target="_blank">Ensembl</a></td>
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<td class="lead">The goal of Ensembl is to automatically annotate the genome, integrate this annotation with other available biological data and make all this publicly available via the web</td>
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<td class="lead"><a href="http://genome-euro.ucsc.edu/cgi-bin/hgGateway?hgsid=85966288&clade=worm&org=0&db=0&redirect=auto&source=genome.ucsc.edu" target="_blank">UCSC Genome Browser</a></td>
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<td class="lead">Browse the C. elegans Genome</td>
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<td class="lead">Browse the <i>C. elegans</i> Genome</td>
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<td class="lead"><a href="http://www.uniprot.org/" target="_blank">UniProt</a></td>

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