diff --git a/doc/source/whatsnew/v1.4.4.rst b/doc/source/whatsnew/v1.4.4.rst
index 57b8fdee5888a..1e7ed256c05ef 100644
--- a/doc/source/whatsnew/v1.4.4.rst
+++ b/doc/source/whatsnew/v1.4.4.rst
@@ -19,6 +19,7 @@ Fixed regressions
 - Fixed regression in :meth:`DataFrame.loc` not updating the cache correctly after values were set (:issue:`47867`)
 - Fixed regression in :meth:`DataFrame.loc` not aligning index in some cases when setting a :class:`DataFrame` (:issue:`47578`)
 - Fixed regression in setting ``None`` or non-string value into a ``string``-dtype Series using a mask (:issue:`47628`)
+- Fixed regression in :meth:`DataFrame.eval` creating a copy when updating inplace (:issue:`47449`)
 -
 
 .. ---------------------------------------------------------------------------
diff --git a/pandas/core/computation/eval.py b/pandas/core/computation/eval.py
index d82cc37b90ad4..70a8bff5d509c 100644
--- a/pandas/core/computation/eval.py
+++ b/pandas/core/computation/eval.py
@@ -18,6 +18,7 @@
 from pandas.core.computation.ops import BinOp
 from pandas.core.computation.parsing import tokenize_string
 from pandas.core.computation.scope import ensure_scope
+from pandas.core.generic import NDFrame
 
 from pandas.io.formats.printing import pprint_thing
 
@@ -384,7 +385,10 @@ def eval(
             try:
                 with warnings.catch_warnings(record=True):
                     # TODO: Filter the warnings we actually care about here.
-                    target[assigner] = ret
+                    if inplace and isinstance(target, NDFrame):
+                        target.loc[:, assigner] = ret
+                    else:
+                        target[assigner] = ret
             except (TypeError, IndexError) as err:
                 raise ValueError("Cannot assign expression output to target") from err
 
diff --git a/pandas/tests/computation/test_eval.py b/pandas/tests/computation/test_eval.py
index 3517068b3d0cc..3051683853a46 100644
--- a/pandas/tests/computation/test_eval.py
+++ b/pandas/tests/computation/test_eval.py
@@ -1966,6 +1966,21 @@ def test_negate_lt_eq_le(engine, parser):
         tm.assert_frame_equal(result, expected)
 
 
+@td.skip_array_manager_not_yet_implemented
+def test_set_inplace():
+    # https://github.com/pandas-dev/pandas/issues/47449
+    # Ensure we don't only update the DataFrame inplace, but also the actual
+    # column values, such that references to this column also get updated
+    df = DataFrame({"A": [1, 2, 3], "B": [4, 5, 6], "C": [7, 8, 9]})
+    result_view = df[:]
+    ser = df["A"]
+    df.eval("A = B + C", inplace=True)
+    expected = DataFrame({"A": [11, 13, 15], "B": [4, 5, 6], "C": [7, 8, 9]})
+    tm.assert_frame_equal(df, expected)
+    tm.assert_series_equal(ser, expected["A"])
+    tm.assert_series_equal(result_view["A"], expected["A"])
+
+
 class TestValidate:
     @pytest.mark.parametrize("value", [1, "True", [1, 2, 3], 5.0])
     def test_validate_bool_args(self, value):