diff --git a/pandas/__init__.py b/pandas/__init__.py
index 8b92ad6cdfebb..cc786d1141c48 100644
--- a/pandas/__init__.py
+++ b/pandas/__init__.py
@@ -105,6 +105,7 @@
     Series,
     DataFrame,
 )
+from pandas.core.col import col
 
 from pandas.core.dtypes.dtypes import SparseDtype
 
@@ -281,6 +282,7 @@
     "array",
     "arrays",
     "bdate_range",
+    "col",
     "concat",
     "crosstab",
     "cut",
diff --git a/pandas/core/col.py b/pandas/core/col.py
new file mode 100644
index 0000000000000..4bb41f019a9ab
--- /dev/null
+++ b/pandas/core/col.py
@@ -0,0 +1,246 @@
+from __future__ import annotations
+
+from collections.abc import (
+    Callable,
+    Hashable,
+)
+from typing import (
+    TYPE_CHECKING,
+    Any,
+)
+
+from pandas.core.dtypes.common import is_scalar
+
+from pandas.core.series import Series
+
+if TYPE_CHECKING:
+    from pandas import DataFrame
+
+
+OP_SYMBOLS = {
+    "__add__": "+",
+    "__radd__": "+",
+    "__sub__": "-",
+    "__rsub__": "-",
+    "__mul__": "*",
+    "__rmul__": "*",
+    "__truediv__": "/",
+    "__rtruediv__": "/",
+    "__floordiv__": "//",
+    "__rfloordiv__": "//",
+    "__ge__": ">=",
+    "__gt__": ">",
+    "__le__": "<=",
+    "__lt__": "<",
+    "__eq__": "==",
+    "__ne__": "!=",
+    "__mod__": "%",
+}
+
+
+def parse_args(df: DataFrame, *args: Any) -> tuple[Series]:
+    return tuple([x._func(df) if isinstance(x, Expr) else x for x in args])
+
+
+def parse_kwargs(df: DataFrame, **kwargs: Any) -> dict[Hashable, Series]:
+    return {
+        key: val._func(df) if isinstance(val, Expr) else val
+        for key, val in kwargs.items()
+    }
+
+
+class Expr:
+    def __init__(
+        self, func: Callable[[DataFrame], Any], repr_str: str | None = None
+    ) -> None:
+        self._func = func
+        self._repr_str = repr_str
+
+    def __call__(self, df: DataFrame) -> Series:
+        result = self._func(df)
+        if not (isinstance(result, Series) or is_scalar(result)):
+            msg = (
+                "Expected function which returns Series or scalar, "
+                f"got function which returns: {type(result)}"
+            )
+            raise TypeError(msg)
+        return result
+
+    def _with_binary_op(self, op: str, other: Any) -> Expr:
+        op_symbol = OP_SYMBOLS.get(op, op)
+
+        if isinstance(other, Expr):
+            if op.startswith("__r"):
+                repr_str = f"({other._repr_str} {op_symbol} {self._repr_str})"
+            else:
+                repr_str = f"({self._repr_str} {op_symbol} {other._repr_str})"
+            return Expr(
+                lambda df: getattr(self._func(df), op)(other._func(df)), repr_str
+            )
+        else:
+            if op.startswith("__r"):
+                repr_str = f"({other!r} {op_symbol} {self._repr_str})"
+            else:
+                repr_str = f"({self._repr_str} {op_symbol} {other!r})"
+            return Expr(lambda df: getattr(self._func(df), op)(other), repr_str)
+
+    # Binary ops
+    def __add__(self, other: Any) -> Expr:
+        return self._with_binary_op("__add__", other)
+
+    def __radd__(self, other: Any) -> Expr:
+        return self._with_binary_op("__radd__", other)
+
+    def __sub__(self, other: Any) -> Expr:
+        return self._with_binary_op("__sub__", other)
+
+    def __rsub__(self, other: Any) -> Expr:
+        return self._with_binary_op("__rsub__", other)
+
+    def __mul__(self, other: Any) -> Expr:
+        return self._with_binary_op("__mul__", other)
+
+    def __rmul__(self, other: Any) -> Expr:
+        return self._with_binary_op("__rmul__", other)
+
+    def __truediv__(self, other: Any) -> Expr:
+        return self._with_binary_op("__truediv__", other)
+
+    def __rtruediv__(self, other: Any) -> Expr:
+        return self._with_binary_op("__rtruediv__", other)
+
+    def __floordiv__(self, other: Any) -> Expr:
+        return self._with_binary_op("__floordiv__", other)
+
+    def __rfloordiv__(self, other: Any) -> Expr:
+        return self._with_binary_op("__rfloordiv__", other)
+
+    def __ge__(self, other: Any) -> Expr:
+        return self._with_binary_op("__ge__", other)
+
+    def __gt__(self, other: Any) -> Expr:
+        return self._with_binary_op("__gt__", other)
+
+    def __le__(self, other: Any) -> Expr:
+        return self._with_binary_op("__le__", other)
+
+    def __lt__(self, other: Any) -> Expr:
+        return self._with_binary_op("__lt__", other)
+
+    def __eq__(self, other: object) -> Expr:  # type: ignore[override]
+        return self._with_binary_op("__eq__", other)
+
+    def __ne__(self, other: object) -> Expr:  # type: ignore[override]
+        return self._with_binary_op("__ne__", other)
+
+    def __mod__(self, other: Any) -> Expr:
+        return self._with_binary_op("__mod__", other)
+
+    # Everything else
+    def __getattr__(self, attr: str, /) -> Callable[..., Expr]:
+        def func(df: DataFrame, *args: Any, **kwargs: Any) -> Any:
+            parsed_args = parse_args(df, *args)
+            parsed_kwargs = parse_kwargs(df, **kwargs)
+            return getattr(self(df), attr)(*parsed_args, **parsed_kwargs)
+
+        def wrapper(*args: Any, **kwargs: Any) -> Expr:
+            # Create a readable representation for method calls
+            args_repr = ", ".join(
+                repr(arg._repr_str if isinstance(arg, Expr) else arg) for arg in args
+            )
+            kwargs_repr = ", ".join(
+                f"{k}={v._repr_str if isinstance(v, Expr) else v!r}"
+                for k, v in kwargs.items()
+            )
+
+            all_args = []
+            if args_repr:
+                all_args.append(args_repr)
+            if kwargs_repr:
+                all_args.append(kwargs_repr)
+
+            args_str = ", ".join(all_args)
+            repr_str = f"{self._repr_str}.{attr}({args_str})"
+
+            return Expr(lambda df: func(df, *args, **kwargs), repr_str)
+
+        return wrapper
+
+    def __repr__(self) -> str:
+        return self._repr_str or "Expr(...)"
+
+    # Namespaces
+    @property
+    def dt(self) -> NamespaceExpr:
+        return NamespaceExpr(self, "dt")
+
+    @property
+    def str(self) -> NamespaceExpr:
+        return NamespaceExpr(self, "str")
+
+    @property
+    def cat(self) -> NamespaceExpr:
+        return NamespaceExpr(self, "cat")
+
+    @property
+    def list(self) -> NamespaceExpr:
+        return NamespaceExpr(self, "list")
+
+    @property
+    def sparse(self) -> NamespaceExpr:
+        return NamespaceExpr(self, "sparse")
+
+    @property
+    def struct(self) -> NamespaceExpr:
+        return NamespaceExpr(self, "struct")
+
+
+class NamespaceExpr:
+    def __init__(self, func: Expr, namespace: str) -> None:
+        self._func = func
+        self._namespace = namespace
+
+    def __getattr__(self, attr: str) -> Any:
+        if isinstance(getattr(getattr(Series, self._namespace), attr), property):
+            repr_str = f"{self._func._repr_str}.{self._namespace}.{attr}"
+            return Expr(
+                lambda df: getattr(getattr(self._func(df), self._namespace), attr),
+                repr_str,
+            )
+
+        def func(df: DataFrame, *args: Any, **kwargs: Any) -> Any:
+            parsed_args = parse_args(df, *args)
+            parsed_kwargs = parse_kwargs(df, **kwargs)
+            return getattr(getattr(self._func(df), self._namespace), attr)(
+                *parsed_args, **parsed_kwargs
+            )
+
+        def wrapper(*args: Any, **kwargs: Any) -> Expr:
+            # Create a readable representation for namespace method calls
+            args_repr = ", ".join(
+                repr(arg._repr_str if isinstance(arg, Expr) else arg) for arg in args
+            )
+            kwargs_repr = ", ".join(
+                f"{k}={v._repr_str if isinstance(v, Expr) else v!r}"
+                for k, v in kwargs.items()
+            )
+
+            all_args = []
+            if args_repr:
+                all_args.append(args_repr)
+            if kwargs_repr:
+                all_args.append(kwargs_repr)
+
+            args_str = ", ".join(all_args)
+            repr_str = f"{self._func._repr_str}.{self._namespace}.{attr}({args_str})"
+
+            return Expr(lambda df: func(df, *args, **kwargs), repr_str)
+
+        return wrapper
+
+
+def col(col_name: Hashable) -> Expr:
+    if not isinstance(col_name, Hashable):
+        msg = f"Expected Hashable, got: {type(col_name)}"
+        raise TypeError(msg)
+    return Expr(lambda df: df[col_name], f"col({col_name!r})")
diff --git a/pandas/tests/api/test_api.py b/pandas/tests/api/test_api.py
index c2e77b69aadcb..f5ba784470072 100644
--- a/pandas/tests/api/test_api.py
+++ b/pandas/tests/api/test_api.py
@@ -107,6 +107,7 @@ class TestPDApi(Base):
     funcs = [
         "array",
         "bdate_range",
+        "col",
         "concat",
         "crosstab",
         "cut",