diff --git a/doc/source/whatsnew/v3.0.0.rst b/doc/source/whatsnew/v3.0.0.rst
index 6722480fb837c..93484c0c96d7b 100644
--- a/doc/source/whatsnew/v3.0.0.rst
+++ b/doc/source/whatsnew/v3.0.0.rst
@@ -895,6 +895,7 @@ Timedelta
 - Accuracy improvement in :meth:`Timedelta.to_pytimedelta` to round microseconds consistently for large nanosecond based Timedelta (:issue:`57841`)
 - Bug in :class:`Timedelta` constructor failing to raise when passed an invalid keyword (:issue:`53801`)
 - Bug in :meth:`DataFrame.cumsum` which was raising ``IndexError`` if dtype is ``timedelta64[ns]`` (:issue:`57956`)
+- Bug in multiplication operations with ``timedelta64`` dtype failing to raise ``TypeError`` when multiplying by ``bool`` objects or dtypes (:issue:`58054`)
 
 Timezones
 ^^^^^^^^^
diff --git a/pandas/core/arrays/timedeltas.py b/pandas/core/arrays/timedeltas.py
index 79c3d74b39666..251d035749dea 100644
--- a/pandas/core/arrays/timedeltas.py
+++ b/pandas/core/arrays/timedeltas.py
@@ -472,6 +472,11 @@ def _add_offset(self, other):
     @unpack_zerodim_and_defer("__mul__")
     def __mul__(self, other) -> Self:
         if is_scalar(other):
+            if lib.is_bool(other):
+                raise TypeError(
+                    f"Cannot multiply '{self.dtype}' by bool, explicitly cast to "
+                    "integers instead"
+                )
             # numpy will accept float and int, raise TypeError for others
             result = self._ndarray * other
             if result.dtype.kind != "m":
@@ -489,6 +494,13 @@ def __mul__(self, other) -> Self:
         if not hasattr(other, "dtype"):
             # list, tuple
             other = np.array(other)
+
+        if other.dtype.kind == "b":
+            # GH#58054
+            raise TypeError(
+                f"Cannot multiply '{self.dtype}' by bool, explicitly cast to "
+                "integers instead"
+            )
         if len(other) != len(self) and not lib.is_np_dtype(other.dtype, "m"):
             # Exclude timedelta64 here so we correctly raise TypeError
             #  for that instead of ValueError
diff --git a/pandas/tests/arithmetic/test_timedelta64.py b/pandas/tests/arithmetic/test_timedelta64.py
index a05dbfc3e57d1..2361a353f3f8a 100644
--- a/pandas/tests/arithmetic/test_timedelta64.py
+++ b/pandas/tests/arithmetic/test_timedelta64.py
@@ -11,6 +11,7 @@
 from pandas._libs.tslibs import timezones
 from pandas.compat import WASM
 from pandas.errors import OutOfBoundsDatetime
+import pandas.util._test_decorators as td
 
 import pandas as pd
 from pandas import (
@@ -1556,6 +1557,51 @@ def test_tdi_rmul_arraylike(self, other, box_with_array):
         commute = tdi * other
         tm.assert_equal(commute, expected)
 
+    def test_td64arr_mul_bool_scalar_raises(self, box_with_array):
+        # GH#58054
+        ser = Series(np.arange(5) * timedelta(hours=1))
+        obj = tm.box_expected(ser, box_with_array)
+
+        msg = r"Cannot multiply 'timedelta64\[ns\]' by bool"
+        with pytest.raises(TypeError, match=msg):
+            True * obj
+        with pytest.raises(TypeError, match=msg):
+            obj * True
+        with pytest.raises(TypeError, match=msg):
+            np.True_ * obj
+        with pytest.raises(TypeError, match=msg):
+            obj * np.True_
+
+    @pytest.mark.parametrize(
+        "dtype",
+        [
+            bool,
+            "boolean",
+            pytest.param("bool[pyarrow]", marks=td.skip_if_no("pyarrow")),
+        ],
+    )
+    def test_td64arr_mul_bool_raises(self, dtype, box_with_array):
+        # GH#58054
+        ser = Series(np.arange(5) * timedelta(hours=1))
+        obj = tm.box_expected(ser, box_with_array)
+
+        other = Series(np.arange(5) < 0.5, dtype=dtype)
+        other = tm.box_expected(other, box_with_array)
+
+        msg = r"Cannot multiply 'timedelta64\[ns\]' by bool"
+        with pytest.raises(TypeError, match=msg):
+            obj * other
+
+        msg2 = msg.replace("rmul", "mul")
+        if dtype == "bool[pyarrow]":
+            # We go through ArrowEA.__mul__ which gives a different message
+            msg2 = (
+                r"operation 'mul' not supported for dtype 'bool\[pyarrow\]' "
+                r"with dtype 'timedelta64\[ns\]'"
+            )
+        with pytest.raises(TypeError, match=msg2):
+            other * obj
+
     # ------------------------------------------------------------------
     # __div__, __rdiv__