diff --git a/.changeset/funny-baboons-wonder.md b/.changeset/funny-baboons-wonder.md
new file mode 100644
index 000000000..91e7b9f89
--- /dev/null
+++ b/.changeset/funny-baboons-wonder.md
@@ -0,0 +1,5 @@
+---
+'@powersync/web': patch
+---
+
+Fix issues with multiple tabs when the Rust client and OPFS is used.
diff --git a/packages/web/src/db/adapters/WorkerWrappedAsyncDatabaseConnection.ts b/packages/web/src/db/adapters/WorkerWrappedAsyncDatabaseConnection.ts
index 57808e3ce..5c4c6902e 100644
--- a/packages/web/src/db/adapters/WorkerWrappedAsyncDatabaseConnection.ts
+++ b/packages/web/src/db/adapters/WorkerWrappedAsyncDatabaseConnection.ts
@@ -15,6 +15,7 @@ export type SharedConnectionWorker = {
 export type WrappedWorkerConnectionOptions<Config extends ResolvedWebSQLOpenOptions = ResolvedWebSQLOpenOptions> = {
   baseConnection: AsyncDatabaseConnection;
   identifier: string;
+  remoteCanCloseUnexpectedly: boolean;
   /**
    * Need a remote in order to keep a reference to the Proxied worker
    */
@@ -29,10 +30,13 @@ export type WrappedWorkerConnectionOptions<Config extends ResolvedWebSQLOpenOpti
 export class WorkerWrappedAsyncDatabaseConnection<Config extends ResolvedWebSQLOpenOptions = ResolvedWebSQLOpenOptions>
   implements AsyncDatabaseConnection
 {
-  protected lockAbortController: AbortController;
+  protected lockAbortController = new AbortController();
+  protected notifyRemoteClosed: AbortController | undefined;
 
   constructor(protected options: WrappedWorkerConnectionOptions<Config>) {
-    this.lockAbortController = new AbortController();
+    if (options.remoteCanCloseUnexpectedly) {
+      this.notifyRemoteClosed = new AbortController();
+    }
   }
 
   protected get baseConnection() {
@@ -43,6 +47,48 @@ export class WorkerWrappedAsyncDatabaseConnection<Config extends ResolvedWebSQLO
     return this.baseConnection.init();
   }
 
+  /**
+   * Marks the remote as closed.
+   *
+   * This can sometimes happen outside of our control, e.g. when a shared worker requests a connection from a tab. When
+   * it happens, all methods on the {@link baseConnection} would never resolve. To avoid livelocks in this scenario, we
+   * throw on all outstanding promises and forbid new calls.
+   */
+  markRemoteClosed() {
+    // Can non-null assert here because this function is only supposed to be called when remoteCanCloseUnexpectedly was
+    // set.
+    this.notifyRemoteClosed!.abort();
+  }
+
+  private withRemote<T>(workerPromise: () => Promise<T>): Promise<T> {
+    const controller = this.notifyRemoteClosed;
+    if (controller) {
+      return new Promise((resolve, reject) => {
+        if (controller.signal.aborted) {
+          reject(new Error('Called operation on closed remote'));
+        }
+
+        function handleAbort() {
+          reject(new Error('Remote peer closed with request in flight'));
+        }
+
+        function completePromise(action: () => void) {
+          controller!.signal.removeEventListener('abort', handleAbort);
+          action();
+        }
+
+        controller.signal.addEventListener('abort', handleAbort);
+
+        workerPromise()
+          .then((data) => completePromise(() => resolve(data)))
+          .catch((e) => completePromise(() => reject(e)));
+      });
+    } else {
+      // Can't close, so just return the inner worker promise unguarded.
+      return workerPromise();
+    }
+  }
+
   /**
    * Get a MessagePort which can be used to share the internals of this connection.
    */
@@ -103,24 +149,27 @@ export class WorkerWrappedAsyncDatabaseConnection<Config extends ResolvedWebSQLO
   async close(): Promise<void> {
     // Abort any pending lock requests.
     this.lockAbortController.abort();
-    await this.baseConnection.close();
-    this.options.remote[Comlink.releaseProxy]();
-    this.options.onClose?.();
+    try {
+      await this.withRemote(() => this.baseConnection.close());
+    } finally {
+      this.options.remote[Comlink.releaseProxy]();
+      this.options.onClose?.();
+    }
   }
 
   execute(sql: string, params?: any[]): Promise<ProxiedQueryResult> {
-    return this.baseConnection.execute(sql, params);
+    return this.withRemote(() => this.baseConnection.execute(sql, params));
   }
 
   executeRaw(sql: string, params?: any[]): Promise<any[][]> {
-    return this.baseConnection.executeRaw(sql, params);
+    return this.withRemote(() => this.baseConnection.executeRaw(sql, params));
   }
 
   executeBatch(sql: string, params?: any[]): Promise<ProxiedQueryResult> {
-    return this.baseConnection.executeBatch(sql, params);
+    return this.withRemote(() => this.baseConnection.executeBatch(sql, params));
   }
 
   getConfig(): Promise<ResolvedWebSQLOpenOptions> {
-    return this.baseConnection.getConfig();
+    return this.withRemote(() => this.baseConnection.getConfig());
   }
 }
diff --git a/packages/web/src/db/adapters/wa-sqlite/WASQLiteDBAdapter.ts b/packages/web/src/db/adapters/wa-sqlite/WASQLiteDBAdapter.ts
index 01ffef3b0..1367ed811 100644
--- a/packages/web/src/db/adapters/wa-sqlite/WASQLiteDBAdapter.ts
+++ b/packages/web/src/db/adapters/wa-sqlite/WASQLiteDBAdapter.ts
@@ -54,6 +54,7 @@ export class WASQLiteDBAdapter extends LockedAsyncDatabaseAdapter {
           const remote = Comlink.wrap<OpenAsyncDatabaseConnection>(workerPort);
           return new WorkerWrappedAsyncDatabaseConnection({
             remote,
+            remoteCanCloseUnexpectedly: false,
             identifier: options.dbFilename,
             baseConnection: await remote({
               ...options,
diff --git a/packages/web/src/db/adapters/wa-sqlite/WASQLiteOpenFactory.ts b/packages/web/src/db/adapters/wa-sqlite/WASQLiteOpenFactory.ts
index 129a3b130..487d121aa 100644
--- a/packages/web/src/db/adapters/wa-sqlite/WASQLiteOpenFactory.ts
+++ b/packages/web/src/db/adapters/wa-sqlite/WASQLiteOpenFactory.ts
@@ -82,6 +82,8 @@ export class WASQLiteOpenFactory extends AbstractWebSQLOpenFactory {
 
       return new WorkerWrappedAsyncDatabaseConnection({
         remote: workerDBOpener,
+        // This tab owns the worker, so we're guaranteed to outlive it.
+        remoteCanCloseUnexpectedly: false,
         baseConnection: await workerDBOpener({
           dbFilename: this.options.dbFilename,
           vfs,
diff --git a/packages/web/src/worker/sync/SharedSyncImplementation.ts b/packages/web/src/worker/sync/SharedSyncImplementation.ts
index 7db98c3d0..f8923c69f 100644
--- a/packages/web/src/worker/sync/SharedSyncImplementation.ts
+++ b/packages/web/src/worker/sync/SharedSyncImplementation.ts
@@ -75,6 +75,7 @@ export type WrappedSyncPort = {
   clientProvider: Comlink.Remote<AbstractSharedSyncClientProvider>;
   db?: DBAdapter;
   currentSubscriptions: SubscribedStream[];
+  closeListeners: (() => void)[];
 };
 
 /**
@@ -274,7 +275,8 @@ export class SharedSyncImplementation extends BaseObserver<SharedSyncImplementat
       const portProvider = {
         port,
         clientProvider: Comlink.wrap<AbstractSharedSyncClientProvider>(port),
-        currentSubscriptions: []
+        currentSubscriptions: [],
+        closeListeners: []
       } satisfies WrappedSyncPort;
       this.ports.push(portProvider);
 
@@ -331,10 +333,13 @@ export class SharedSyncImplementation extends BaseObserver<SharedSyncImplementat
       return () => {};
     }
 
+    for (const closeListener of trackedPort.closeListeners) {
+      closeListener();
+    }
+
     if (this.dbAdapter && this.dbAdapter == trackedPort.db) {
-      if (shouldReconnect) {
-        await this.connectionManager.disconnect();
-      }
+      // Unconditionally close the connection because the database it's writing to has just been closed.
+      await this.connectionManager.disconnect();
 
       // Clearing the adapter will result in a new one being opened in connect
       this.dbAdapter = null;
@@ -344,10 +349,6 @@ export class SharedSyncImplementation extends BaseObserver<SharedSyncImplementat
       }
     }
 
-    if (trackedPort.db) {
-      await trackedPort.db.close();
-    }
-
     // Re-index subscriptions, the subscriptions of the removed port would no longer be considered.
     this.collectActiveSubscriptions();
 
@@ -473,11 +474,21 @@ export class SharedSyncImplementation extends BaseObserver<SharedSyncImplementat
     const locked = new LockedAsyncDatabaseAdapter({
       name: identifier,
       openConnection: async () => {
-        return new WorkerWrappedAsyncDatabaseConnection({
+        const wrapped = new WorkerWrappedAsyncDatabaseConnection({
           remote,
           baseConnection: db,
-          identifier
+          identifier,
+          // It's possible for this worker to outlive the client hosting the database for us. We need to be prepared for
+          // that and ensure pending requests are aborted when the tab is closed.
+          remoteCanCloseUnexpectedly: true
         });
+        lastClient.closeListeners.push(() => {
+          this.logger.info('Aborting open connection because associated tab closed.');
+          wrapped.close();
+          wrapped.markRemoteClosed();
+        });
+
+        return wrapped;
       },
       logger: this.logger
     });
diff --git a/packages/web/src/worker/sync/WorkerClient.ts b/packages/web/src/worker/sync/WorkerClient.ts
index 22c44f4ba..1dfffe9b2 100644
--- a/packages/web/src/worker/sync/WorkerClient.ts
+++ b/packages/web/src/worker/sync/WorkerClient.ts
@@ -41,7 +41,9 @@ export class WorkerClient {
 
   private async removePort() {
     if (this.resolvedPort) {
-      const release = await this.sync.removePort(this.resolvedPort);
+      const resolved = this.resolvedPort;
+      this.resolvedPort = null;
+      const release = await this.sync.removePort(resolved);
       this.resolvedPort = null;
       this.port.postMessage({
         event: SharedSyncClientEvent.CLOSE_ACK,