diff --git a/ChangeLog b/ChangeLog
index 45e882190..e44509b37 100644
--- a/ChangeLog
+++ b/ChangeLog
@@ -7,6 +7,12 @@ What's New in astroid 4.0.0?
 ============================
 Release date: TBA
 
+* Add support for type constraints (`isinstance(x, y)`) in inference.
+
+  Closes pylint-dev/pylint#1162
+  Closes pylint-dev/pylint#4635
+  Closes pylint-dev/pylint#10469
+
 * Support constraints from ternary expressions in inference.
 
   Closes pylint-dev/pylint#9729
diff --git a/astroid/brain/brain_builtin_inference.py b/astroid/brain/brain_builtin_inference.py
index e21d36141..a2ca95514 100644
--- a/astroid/brain/brain_builtin_inference.py
+++ b/astroid/brain/brain_builtin_inference.py
@@ -763,7 +763,7 @@ def infer_issubclass(callnode, context: InferenceContext | None = None):
     # The right hand argument is the class(es) that the given
     # object is to be checked against.
     try:
-        class_container = _class_or_tuple_to_container(
+        class_container = helpers.class_or_tuple_to_container(
             class_or_tuple_node, context=context
         )
     except InferenceError as exc:
@@ -798,7 +798,7 @@ def infer_isinstance(
     # The right hand argument is the class(es) that the given
     # obj is to be check is an instance of
     try:
-        class_container = _class_or_tuple_to_container(
+        class_container = helpers.class_or_tuple_to_container(
             class_or_tuple_node, context=context
         )
     except InferenceError as exc:
@@ -814,30 +814,6 @@ def infer_isinstance(
     return nodes.Const(isinstance_bool)
 
 
-def _class_or_tuple_to_container(
-    node: InferenceResult, context: InferenceContext | None = None
-) -> list[InferenceResult]:
-    # Move inferences results into container
-    # to simplify later logic
-    # raises InferenceError if any of the inferences fall through
-    try:
-        node_infer = next(node.infer(context=context))
-    except StopIteration as e:
-        raise InferenceError(node=node, context=context) from e
-    # arg2 MUST be a type or a TUPLE of types
-    # for isinstance
-    if isinstance(node_infer, nodes.Tuple):
-        try:
-            class_container = [
-                next(node.infer(context=context)) for node in node_infer.elts
-            ]
-        except StopIteration as e:
-            raise InferenceError(node=node, context=context) from e
-    else:
-        class_container = [node_infer]
-    return class_container
-
-
 def infer_len(node, context: InferenceContext | None = None) -> nodes.Const:
     """Infer length calls.
 
diff --git a/astroid/constraint.py b/astroid/constraint.py
index 692d22d03..ca7f743ea 100644
--- a/astroid/constraint.py
+++ b/astroid/constraint.py
@@ -10,7 +10,8 @@
 from collections.abc import Iterator
 from typing import TYPE_CHECKING
 
-from astroid import nodes, util
+from astroid import helpers, nodes, util
+from astroid.exceptions import AstroidTypeError, InferenceError, MroError
 from astroid.typing import InferenceResult
 
 if sys.version_info >= (3, 11):
@@ -125,6 +126,55 @@ def satisfied_by(self, inferred: InferenceResult) -> bool:
         return self.negate ^ inferred_booleaness
 
 
+class TypeConstraint(Constraint):
+    """Represents an "isinstance(x, y)" constraint."""
+
+    def __init__(
+        self, node: nodes.NodeNG, classinfo: nodes.NodeNG, negate: bool
+    ) -> None:
+        super().__init__(node=node, negate=negate)
+        self.classinfo = classinfo
+
+    @classmethod
+    def match(
+        cls, node: _NameNodes, expr: nodes.NodeNG, negate: bool = False
+    ) -> Self | None:
+        """Return a new constraint for node if expr matches the
+        "isinstance(x, y)" pattern. Else, return None.
+        """
+        is_instance_call = (
+            isinstance(expr, nodes.Call)
+            and isinstance(expr.func, nodes.Name)
+            and expr.func.name == "isinstance"
+            and not expr.keywords
+            and len(expr.args) == 2
+        )
+        if is_instance_call and _matches(expr.args[0], node):
+            return cls(node=node, classinfo=expr.args[1], negate=negate)
+
+        return None
+
+    def satisfied_by(self, inferred: InferenceResult) -> bool:
+        """Return True for uninferable results, or depending on negate flag:
+
+        - negate=False: satisfied when inferred is an instance of the checked types.
+        - negate=True: satisfied when inferred is not an instance of the checked types.
+        """
+        if isinstance(inferred, util.UninferableBase):
+            return True
+
+        try:
+            types = helpers.class_or_tuple_to_container(self.classinfo)
+            matches_checked_types = helpers.object_isinstance(inferred, types)
+
+            if isinstance(matches_checked_types, util.UninferableBase):
+                return True
+
+            return self.negate ^ matches_checked_types
+        except (InferenceError, AstroidTypeError, MroError):
+            return True
+
+
 def get_constraints(
     expr: _NameNodes, frame: nodes.LocalsDictNodeNG
 ) -> dict[nodes.If | nodes.IfExp, set[Constraint]]:
@@ -159,6 +209,7 @@ def get_constraints(
     (
         NoneConstraint,
         BooleanConstraint,
+        TypeConstraint,
     )
 )
 """All supported constraint types."""
diff --git a/astroid/helpers.py b/astroid/helpers.py
index 9c370aa32..375bb918f 100644
--- a/astroid/helpers.py
+++ b/astroid/helpers.py
@@ -170,6 +170,30 @@ def object_issubclass(
     return _object_type_is_subclass(node, class_or_seq, context=context)
 
 
+def class_or_tuple_to_container(
+    node: InferenceResult, context: InferenceContext | None = None
+) -> list[InferenceResult]:
+    # Move inferences results into container
+    # to simplify later logic
+    # raises InferenceError if any of the inferences fall through
+    try:
+        node_infer = next(node.infer(context=context))
+    except StopIteration as e:
+        raise InferenceError(node=node, context=context) from e
+    # arg2 MUST be a type or a TUPLE of types
+    # for isinstance
+    if isinstance(node_infer, nodes.Tuple):
+        try:
+            class_container = [
+                next(node.infer(context=context)) for node in node_infer.elts
+            ]
+        except StopIteration as e:
+            raise InferenceError(node=node, context=context) from e
+    else:
+        class_container = [node_infer]
+    return class_container
+
+
 def has_known_bases(klass, context: InferenceContext | None = None) -> bool:
     """Return whether all base classes of a class could be inferred."""
     try:
diff --git a/tests/test_constraint.py b/tests/test_constraint.py
index 4859d4241..93fc1e26e 100644
--- a/tests/test_constraint.py
+++ b/tests/test_constraint.py
@@ -8,6 +8,7 @@
 import pytest
 
 from astroid import builder, nodes
+from astroid.bases import Instance
 from astroid.util import Uninferable
 
 
@@ -19,6 +20,8 @@ def common_params(node: str) -> pytest.MarkDecorator:
             (f"{node} is not None", 3, None),
             (f"{node}", 3, None),
             (f"not {node}", None, 3),
+            (f"isinstance({node}, int)", 3, None),
+            (f"isinstance({node}, (int, str))", 3, None),
         ),
     )
 
@@ -773,3 +776,134 @@ def method(self, x = {fail_val}):
     assert isinstance(inferred[0], nodes.Const)
     assert inferred[0].value == fail_val
     assert inferred[1].value is Uninferable
+
+
+def test_isinstance_equal_types() -> None:
+    """Test constraint for an object whose type is equal to the checked type."""
+    node = builder.extract_node(
+        """
+    class A:
+        pass
+
+    x = A()
+
+    if isinstance(x, A):
+        x  #@
+    """
+    )
+
+    inferred = node.inferred()
+    assert len(inferred) == 1
+    assert isinstance(inferred[0], Instance)
+    assert isinstance(inferred[0]._proxied, nodes.ClassDef)
+    assert inferred[0].name == "A"
+
+
+def test_isinstance_subtype() -> None:
+    """Test constraint for an object whose type is a strict subtype of the checked type."""
+    node = builder.extract_node(
+        """
+    class A:
+        pass
+
+    class B(A):
+        pass
+
+    x = B()
+
+    if isinstance(x, A):
+        x  #@
+    """
+    )
+
+    inferred = node.inferred()
+    assert len(inferred) == 1
+    assert isinstance(inferred[0], Instance)
+    assert isinstance(inferred[0]._proxied, nodes.ClassDef)
+    assert inferred[0].name == "B"
+
+
+def test_isinstance_unrelated_types():
+    """Test constraint for an object whose type is not related to the checked type."""
+    node = builder.extract_node(
+        """
+    class A:
+        pass
+
+    class B:
+        pass
+
+    x = A()
+
+    if isinstance(x, B):
+        x  #@
+    """
+    )
+
+    inferred = node.inferred()
+    assert len(inferred) == 1
+    assert inferred[0] is Uninferable
+
+
+def test_isinstance_supertype():
+    """Test constraint for an object whose type is a strict supertype of the checked type."""
+    node = builder.extract_node(
+        """
+    class A:
+        pass
+
+    class B(A):
+        pass
+
+    x = A()
+
+    if isinstance(x, B):
+        x  #@
+    """
+    )
+
+    inferred = node.inferred()
+    assert len(inferred) == 1
+    assert inferred[0] is Uninferable
+
+
+def test_isinstance_keyword_arguments():
+    """Test that constraint does not apply when `isinstance` is called
+    with keyword arguments.
+    """
+    n1, n2 = builder.extract_node(
+        """
+    x = 3
+
+    if isinstance(object=x, classinfo=str):
+        x  #@
+
+    if isinstance(x, str, object=x, classinfo=str):
+        x  #@
+    """
+    )
+
+    for node in (n1, n2):
+        inferred = node.inferred()
+        assert len(inferred) == 1
+        assert isinstance(inferred[0], nodes.Const)
+        assert inferred[0].value == 3
+
+
+def test_isinstance_extra_argument():
+    """Test that constraint does not apply when `isinstance` is called
+    with more than two positional arguments.
+    """
+    node = builder.extract_node(
+        """
+    x = 3
+
+    if isinstance(x, str, bool):
+        x  #@
+    """
+    )
+
+    inferred = node.inferred()
+    assert len(inferred) == 1
+    assert isinstance(inferred[0], nodes.Const)
+    assert inferred[0].value == 3