diff --git a/cibuildwheel/frontend.py b/cibuildwheel/frontend.py
index 7973354fe..827cdbd5e 100644
--- a/cibuildwheel/frontend.py
+++ b/cibuildwheel/frontend.py
@@ -1,4 +1,5 @@
 import dataclasses
+import os
 import shlex
 import typing
 from collections.abc import Sequence
@@ -37,6 +38,15 @@ def options_summary(self) -> str | dict[str, str]:
 
 
 def _get_verbosity_flags(level: int, frontend: BuildFrontendName) -> list[str]:
+    # The pseudo build-frontend provided by pyodide-build does not yet support
+    # tuning its verbosity level, see https://github.com/pyodide/pyodide-build/issues/222
+    # We can use the "PYODIDE" env var to detect if we're running in that context.
+    if os.environ.get("PYODIDE") == "1":
+        if level != 0:
+            log.warning(f"build_verbosity {level} is not supported for Pyodide builds. Ignoring.")
+
+        return []
+
     if level < 0:
         if frontend == "pip":
             return ["-" + -level * "q"]
diff --git a/cibuildwheel/platforms/pyodide.py b/cibuildwheel/platforms/pyodide.py
index 60d707078..625699f0a 100644
--- a/cibuildwheel/platforms/pyodide.py
+++ b/cibuildwheel/platforms/pyodide.py
@@ -414,6 +414,7 @@ def build(options: Options, tmp_path: Path) -> None:
                     shell(before_build_prepared, env=env)
 
                 log.step("Building wheel...")
+                env["PYODIDE"] = "1"
 
                 extra_flags = get_build_frontend_extra_flags(
                     build_frontend, build_options.build_verbosity, build_options.config_settings
@@ -423,6 +424,7 @@ def build(options: Options, tmp_path: Path) -> None:
                 if constraints_path:
                     combine_constraints(build_env, constraints_path, identifier_tmp_dir)
                 build_env["VIRTUALENV_PIP"] = pip_version
+                build_env["PYODIDE"] = "1"
                 call(
                     "pyodide",
                     "build",
diff --git a/unit_test/main_tests/main_options_test.py b/unit_test/main_tests/main_options_test.py
index 45cbe0562..865d68851 100644
--- a/unit_test/main_tests/main_options_test.py
+++ b/unit_test/main_tests/main_options_test.py
@@ -8,7 +8,11 @@
 
 from cibuildwheel.__main__ import main
 from cibuildwheel.environment import ParsedEnvironment
-from cibuildwheel.frontend import _split_config_settings, parse_config_settings
+from cibuildwheel.frontend import (
+    _get_verbosity_flags,
+    _split_config_settings,
+    parse_config_settings,
+)
 from cibuildwheel.options import BuildOptions, _get_pinned_container_images
 from cibuildwheel.selector import BuildSelector, EnableGroup
 from cibuildwheel.util import resources
@@ -390,6 +394,21 @@ def test_build_verbosity(
     assert build_options.build_verbosity == expected_verbosity
 
 
+@pytest.mark.parametrize("verbosity", [0, 1, 2, -1, 3])
+def test_get_verbosity_flags_pyodide(monkeypatch, capsys, verbosity):
+    monkeypatch.setenv("PYODIDE", "1")
+
+    assert _get_verbosity_flags(verbosity, "build") == []
+
+    _, err = capsys.readouterr()
+
+    if verbosity != 0:
+        assert "build_verbosity" in err
+        assert "not supported for Pyodide builds" in err
+    else:
+        assert "not supported for Pyodide builds" not in err
+
+
 @pytest.mark.parametrize("platform_specific", [False, True])
 def test_config_settings(platform_specific, platform, intercepted_build_args, monkeypatch):
     config_settings = (