diff --git a/Lib/test/test_typing.py b/Lib/test/test_typing.py
index 2f1f9e86a0bce4..3c316ff3482373 100644
--- a/Lib/test/test_typing.py
+++ b/Lib/test/test_typing.py
@@ -8,6 +8,7 @@
 import inspect
 import itertools
 import operator
+import os
 import pickle
 import re
 import sys
@@ -4252,6 +4253,9 @@ def test_builtin_protocol_allowlist(self):
             class CustomProtocol(TestCase, Protocol):
                 pass
 
+        class CustomPathLikeProtocol(os.PathLike, Protocol):
+            pass
+
         class CustomContextManager(typing.ContextManager, Protocol):
             pass
 
diff --git a/Lib/typing.py b/Lib/typing.py
index c924c767042552..922a887599425c 100644
--- a/Lib/typing.py
+++ b/Lib/typing.py
@@ -1943,6 +1943,7 @@ def _allow_reckless_class_checks(depth=2):
         'Hashable', 'Sized', 'Container', 'Collection', 'Reversible', 'Buffer',
     ],
     'contextlib': ['AbstractContextManager', 'AbstractAsyncContextManager'],
+    'os': ['PathLike'],
 }
 
 
diff --git a/Misc/NEWS.d/next/Library/2024-11-11-14-52-21.gh-issue-126705.0W7jFW.rst b/Misc/NEWS.d/next/Library/2024-11-11-14-52-21.gh-issue-126705.0W7jFW.rst
new file mode 100644
index 00000000000000..f49c9c765d778f
--- /dev/null
+++ b/Misc/NEWS.d/next/Library/2024-11-11-14-52-21.gh-issue-126705.0W7jFW.rst
@@ -0,0 +1 @@
+Allow :class:`os.PathLike` to be a base for Protocols.