diff --git a/Lib/unittest/async_case.py b/Lib/unittest/async_case.py
index 63ff6a5d1f8b61..e761ba7e53c5eb 100644
--- a/Lib/unittest/async_case.py
+++ b/Lib/unittest/async_case.py
@@ -5,6 +5,7 @@
 
 from .case import TestCase
 
+__unittest = True
 
 class IsolatedAsyncioTestCase(TestCase):
     # Names intentionally have a long prefix
diff --git a/Misc/NEWS.d/next/Library/2021-12-19-10-47-24.bpo-46128.Qv3EK1.rst b/Misc/NEWS.d/next/Library/2021-12-19-10-47-24.bpo-46128.Qv3EK1.rst
new file mode 100644
index 00000000000000..7d11d20d94e8a3
--- /dev/null
+++ b/Misc/NEWS.d/next/Library/2021-12-19-10-47-24.bpo-46128.Qv3EK1.rst
@@ -0,0 +1,2 @@
+Strip :class:`unittest.IsolatedAsyncioTestCase` stack frames from reported
+stacktraces.