diff --git a/Lib/_pyrepl/simple_interact.py b/Lib/_pyrepl/simple_interact.py
index a5033496712a73..0d84a70ad6ab3e 100644
--- a/Lib/_pyrepl/simple_interact.py
+++ b/Lib/_pyrepl/simple_interact.py
@@ -164,6 +164,8 @@ def maybe_run_command(statement: str) -> bool:
             r = _get_reader()
             if r.input_trans is r.isearch_trans:
                 r.do_cmd(("isearch-end", [""]))
+            if r.cmpltn_menu_choices:
+                r.cmpltn_reset()
             r.pos = len(r.get_unicode())
             r.dirty = True
             r.refresh()
diff --git a/Misc/NEWS.d/next/Tools-Demos/2025-01-03-10-28-31.gh-issue-127073.r8-flH.rst b/Misc/NEWS.d/next/Tools-Demos/2025-01-03-10-28-31.gh-issue-127073.r8-flH.rst
new file mode 100644
index 00000000000000..680e2f25f517b8
--- /dev/null
+++ b/Misc/NEWS.d/next/Tools-Demos/2025-01-03-10-28-31.gh-issue-127073.r8-flH.rst
@@ -0,0 +1,4 @@
+Previously in the REPL, when a completion list was displayed and KeyboardInterrupt
+was triggered using Ctrl+C, the completion list would persist and duplicate with
+each KeyboardInterrupt. Now, when KeyboardInterrupt occurs, the completion list
+is properly cleared, consistent with the behavior of other errors.