diff --git a/Lib/test/libregrtest/cmdline.py b/Lib/test/libregrtest/cmdline.py
index 81c7106ac0c0f4..07681d75448e24 100644
--- a/Lib/test/libregrtest/cmdline.py
+++ b/Lib/test/libregrtest/cmdline.py
@@ -44,11 +44,19 @@
 doing memory analysis on the Python interpreter, which process tends to
 consume too many resources to run the full regression test non-stop.
 
--S is used to continue running tests after an aborted run.  It will
-maintain the order a standard run (ie, this assumes -r is not used).
+-S is used to resume running tests after an interrupted run.  It will
+maintain the order a standard run (i.e. it assumes -r is not used).
 This is useful after the tests have prematurely stopped for some external
-reason and you want to start running from where you left off rather
-than starting from the beginning.
+reason and you want to resume the run from where you left off rather
+than starting from the beginning. Note: this is different from --prioritize.
+
+--prioritize is used to influence the order of selected tests, such that
+the tests listed as an argument are executed first. This is especially
+useful when combined with -j and -r to pin the longest-running tests
+to start at the beginning of a test run. Pass --prioritize=test_a,test_b
+to make test_a run first, followed by test_b, and then the other tests.
+If test_a wasn't selected for execution by regular means, --prioritize will
+not make it execute.
 
 -f reads the names of tests from the file given as f's argument, one
 or more test names per line.  Whitespace is ignored.  Blank lines and
@@ -236,7 +244,7 @@ def _create_parser():
                        help='wait for user input, e.g., allow a debugger '
                             'to be attached')
     group.add_argument('-S', '--start', metavar='START',
-                       help='the name of the test at which to start.' +
+                       help='resume an interrupted run at the following test.' +
                             more_details)
     group.add_argument('-p', '--python', metavar='PYTHON',
                        help='Command to run Python test subprocesses with.')
@@ -263,6 +271,10 @@ def _create_parser():
     group = parser.add_argument_group('Selecting tests')
     group.add_argument('-r', '--randomize', action='store_true',
                        help='randomize test execution order.' + more_details)
+    group.add_argument('--prioritize', metavar='TEST1,TEST2,...',
+                       action='append', type=priority_list,
+                       help='select these tests first, even if the order is'
+                            ' randomized.' + more_details)
     group.add_argument('-f', '--fromfile', metavar='FILE',
                        help='read names of tests to run from a file.' +
                             more_details)
@@ -406,6 +418,10 @@ def resources_list(string):
     return u
 
 
+def priority_list(string):
+    return string.split(",")
+
+
 def _parse_args(args, **kwargs):
     # Defaults
     ns = Namespace()
@@ -551,4 +567,10 @@ def _parse_args(args, **kwargs):
             print(msg, file=sys.stderr, flush=True)
             sys.exit(2)
 
+    ns.prioritize = [
+        test
+        for test_list in (ns.prioritize or ())
+        for test in test_list
+    ]
+
     return ns
diff --git a/Lib/test/libregrtest/main.py b/Lib/test/libregrtest/main.py
index 19beb2919faafa..713cbedb299706 100644
--- a/Lib/test/libregrtest/main.py
+++ b/Lib/test/libregrtest/main.py
@@ -142,6 +142,7 @@ def __init__(self, ns: Namespace, _add_python_opts: bool = False):
             self.random_seed = random.getrandbits(32)
         else:
             self.random_seed = ns.random_seed
+        self.prioritize_tests: tuple[str, ...] = tuple(ns.prioritize)
 
         self.parallel_threads = ns.parallel_threads
 
@@ -237,6 +238,16 @@ def find_tests(self, tests: TestList | None = None) -> tuple[TestTuple, TestList
         if self.randomize:
             random.shuffle(selected)
 
+        for priority_test in reversed(self.prioritize_tests):
+            try:
+                selected.remove(priority_test)
+            except ValueError:
+                print(f"warning: --prioritize={priority_test} used"
+                        f" but test not actually selected")
+                continue
+            else:
+                selected.insert(0, priority_test)
+
         return (tuple(selected), tests)
 
     @staticmethod
diff --git a/Misc/NEWS.d/next/Tests/2025-04-18-14-00-38.gh-issue-132678.j_ZKf2.rst b/Misc/NEWS.d/next/Tests/2025-04-18-14-00-38.gh-issue-132678.j_ZKf2.rst
new file mode 100644
index 00000000000000..e079cd46a7f066
--- /dev/null
+++ b/Misc/NEWS.d/next/Tests/2025-04-18-14-00-38.gh-issue-132678.j_ZKf2.rst
@@ -0,0 +1,3 @@
+Add ``--prioritize`` to ``-m test``. This option allows the user to specify
+which selected tests should execute first, even if the order is otherwise
+randomized. This is particularly useful for tests that run the longest.