diff --git a/mypyc/lib-rt/mypyc_util.h b/mypyc/lib-rt/mypyc_util.h
index 80019d23bb06..64bf025aec27 100644
--- a/mypyc/lib-rt/mypyc_util.h
+++ b/mypyc/lib-rt/mypyc_util.h
@@ -31,6 +31,8 @@
 // Here just for consistency
 #define CPy_XDECREF(p) Py_XDECREF(p)
 
+#ifndef Py_GIL_DISABLED
+
 // The *_NO_IMM operations below perform refcount manipulation for
 // non-immortal objects (Python 3.12 and later).
 //
@@ -60,6 +62,14 @@ static inline void CPy_XDECREF_NO_IMM(PyObject *op)
 #define CPy_DECREF_NO_IMM(op) CPy_DECREF_NO_IMM((PyObject *)(op))
 #define CPy_XDECREF_NO_IMM(op) CPy_XDECREF_NO_IMM((PyObject *)(op))
 
+#else
+
+#define CPy_INCREF_NO_IMM(op) CPy_INCREF(op)
+#define CPy_DECREF_NO_IMM(op) CPy_DECREF(op)
+#define CPy_XDECREF_NO_IMM(op) CPy_XDECREF(op)
+
+#endif
+
 // Tagged integer -- our representation of Python 'int' objects.
 // Small enough integers are represented as unboxed integers (shifted
 // left by 1); larger integers (larger than 63 bits on a 64-bit