diff --git a/mypyc/irbuild/expression.py b/mypyc/irbuild/expression.py
index 59ecc4ac2c5c..f6636a0e7b62 100644
--- a/mypyc/irbuild/expression.py
+++ b/mypyc/irbuild/expression.py
@@ -590,8 +590,12 @@ def transform_index_expr(builder: IRBuilder, expr: IndexExpr) -> Value:
 
     base = builder.accept(expr.base, can_borrow=can_borrow_base)
 
-    if isinstance(base.type, RTuple) and isinstance(index, IntExpr):
-        return builder.add(TupleGet(base, index.value, expr.line))
+    if isinstance(base.type, RTuple):
+        folded_index = constant_fold_expr(builder, index)
+        if isinstance(folded_index, int):
+            length = len(base.type.types)
+            if -length <= folded_index <= length - 1:
+                return builder.add(TupleGet(base, folded_index, expr.line))
 
     if isinstance(index, SliceExpr):
         value = try_gen_slice_op(builder, base, index)