diff --git a/setup.py b/setup.py
index 5e69fa50f52..829b9c2f910 100644
--- a/setup.py
+++ b/setup.py
@@ -6,6 +6,7 @@
 import shutil
 import subprocess
 import sys
+import sysconfig
 import warnings
 from pathlib import Path
 
@@ -136,6 +137,8 @@ def get_macros_and_flags():
     if sys.platform == "win32":
         define_macros += [("torchvision_EXPORTS", None)]
         extra_compile_args["cxx"].append("/MP")
+        if sysconfig.get_config_var("Py_GIL_DISABLED"):
+            extra_compile_args["cxx"].append("-DPy_GIL_DISABLED")
 
     if DEBUG:
         extra_compile_args["cxx"].append("-g")