diff --git a/docs/jobs/default_profile_setter.md b/docs/jobs/default_profile_setter.md
index 9f1dad27..c565e133 100644
--- a/docs/jobs/default_profile_setter.md
+++ b/docs/jobs/default_profile_setter.md
@@ -16,6 +16,18 @@ Sample job configuration in your scenario file:
       force_profile_selection_policy: true
 ```
 
+On Windows, if you want to ensure that double-clicking on QGIS Project files will launch QGIS with the chosen default profile and disable version checking:
+
+```yaml
+- name: Set default profile to conf_qgis_fr
+    uses: default-profile-setter
+    with:
+      profile: conf_qgis_fr
+      force_profile_selection_policy: true
+      force_profile_file_association: true
+      profile_file_association_arguments: "--noversioncheck"
+```
+
 ----
 
 ## Options
@@ -29,6 +41,22 @@ Name of the profile to set as default profile.
 Force the key `selectionPolicy` to 1, which will always open the profile defined in the `defaultProfile` key in `profiles.ini` file. In this context, this job will force QGIS to always start with the profile specified in this job.
 It's the same behavior as [the option _Always use profile_ in QGIS user profiles preferences](https://docs.qgis.org/latest/en/docs/user_manual/introduction/qgis_configuration.html#setting-user-profile).
 
+### force_profile_file_association
+
+:::{note}
+Windows-only feature
+:::
+
+Modify the Windows registry to ensure that QGIS Project files always open with the default profile when launched.
+
+### profile_file_association_arguments
+
+:::{note}
+Windows-only feature
+:::
+
+Arguments to pass to QGIS executable.
+
 ----
 
 ## Schema
diff --git a/docs/schemas/scenario/jobs/default-profile-setter.json b/docs/schemas/scenario/jobs/default-profile-setter.json
index 8c3dfe6b..675407a7 100644
--- a/docs/schemas/scenario/jobs/default-profile-setter.json
+++ b/docs/schemas/scenario/jobs/default-profile-setter.json
@@ -13,6 +13,24 @@
             "description": "Force the profile selection policy to 1 (always open default profile).",
             "type": "boolean",
             "default": false
+        },
+        "force_profile_file_association": {
+            "description": "Force the QGIS project file association to starts QGIS with the default profile.",
+            "type": "boolean",
+            "default": false
+        },
+        "profile_file_association_arguments": {
+            "description": "Arguments to pass to QGIS executable when force_profile_file_association is true.",
+            "type": "string",
+            "example": "--noversioncheck"
+        },
+        "force_registry_key_creation": {
+            "description": "Force the creation of the registry key for the default profile. This is useful when QGIS is not installed yet.",
+            "type": "boolean",
+            "default": false
         }
-    }
+    },
+    "required": [
+        "profile"
+    ]
 }
diff --git a/qgis_deployment_toolbelt/jobs/job_default_profile_setter.py b/qgis_deployment_toolbelt/jobs/job_default_profile_setter.py
index f85eb678..70844aa1 100644
--- a/qgis_deployment_toolbelt/jobs/job_default_profile_setter.py
+++ b/qgis_deployment_toolbelt/jobs/job_default_profile_setter.py
@@ -13,10 +13,12 @@
 
 # Standard library
 import logging
+from sys import platform as opersys
 
 # package
 from qgis_deployment_toolbelt.jobs.generic_job import GenericJob
 from qgis_deployment_toolbelt.utils.ini_parser_with_path import CustomConfigParser
+from qgis_deployment_toolbelt.utils.win32utils import set_qgis_command
 
 # #############################################################################
 # ########## Globals ###############
@@ -52,6 +54,29 @@ class JobDefaultProfileSetter(GenericJob):
             "possible_values": None,
             "condition": None,
         },
+        "force_profile_file_association": {
+            "type": bool,
+            "required": False,
+            "default": False,
+            "possible_values": None,
+            "condition": None,
+        },
+        "profile_file_association_arguments": {
+            "type": str,
+            "required": False,
+            "default": None,
+            "possible_values": None,
+            "condition": lambda options: options.get("force_profile_file_association")
+            is True,
+        },
+        "force_registry_key_creation": {
+            "type": bool,
+            "required": False,
+            "default": False,
+            "possible_values": None,
+            "condition": lambda options: options.get("force_profile_file_association")
+            is True,
+        },
     }
 
     def __init__(self, options: dict) -> None:
@@ -81,32 +106,61 @@ def run(self) -> None:
             logger.error("No QGIS profile matching the provided profile name.")
             return
 
-        ini_profiles_path = self.qgis_profiles_path / "profiles.ini"
+        self.ini_profiles_path = self.qgis_profiles_path / "profiles.ini"
 
         # check if the profiles.ini file exists and create it with default profile set
         # if not
-        if not ini_profiles_path.exists():
-            logger.warning(
-                "Configuration file profiles.ini doesn't exist. "
-                "It will be created but maybe it was not the expected behavior."
+        if not self.ini_profiles_path.exists():
+            self._create_ini_profiles()
+        else:
+            self._alter_ini_profiles()
+
+        if self.options.get("force_profile_file_association"):
+            qgis_cmd = (
+                f'"{self.os_config.get_qgis_bin_path}" --profile "{qdt_profile.name}"'
             )
-            ini_profiles_path.touch(exist_ok=True)
+            if self.options.get("profile_file_association_arguments"):
+                qgis_cmd += f' {self.options.get("profile_file_association_arguments")}'
+            qgis_cmd += ' "%1"'
+            logger.debug(f"Command to set file association: {qgis_cmd}")
+            if opersys == "win32":
+                command_setted = set_qgis_command(
+                    qgis_cmd=qgis_cmd,
+                    force_key_creation=self.options.get(
+                        "force_registry_key_creation", False
+                    ),
+                )
+                if not command_setted:
+                    logger.error(
+                        "Failed to set file association for the default profile."
+                    )
+            else:
+                logger.warning(
+                    "File association is only supported on Windows. "
+                    "Skipping file association setting."
+                )
+
+        logger.debug(f"Job {self.ID} ran successfully.")
+
+    def _create_ini_profiles(self) -> None:
+        """Create the profiles.ini file with the default profile."""
+        if not self.ini_profiles_path.exists():
+            self.ini_profiles_path.touch(exist_ok=True)
             data = f"[core]\ndefaultProfile={self.options.get('profile')}"
             if self.options.get("force_profile_selection_policy"):
                 data += "\nselectionPolicy=1"
-            ini_profiles_path.write_text(
+            self.ini_profiles_path.write_text(
                 data=data,
                 encoding="UTF8",
             )
             logger.info(f"Default profile set to {self.options.get('profile')}")
-            logger.debug(f"Job {self.ID} ran successfully.")
-            return
 
+    def _alter_ini_profiles(self) -> None:
+        """Alter the ini profiles with the default profile."""
         ini_profiles = CustomConfigParser()
         ini_profiles.optionxform = str
         ini_profiles.read(self.qgis_profiles_path / "profiles.ini", encoding="UTF8")
 
-        # set the default profile
         if not ini_profiles.has_section("core"):
             ini_profiles.add_section("core")
 
@@ -122,8 +176,6 @@ def run(self) -> None:
                 )
             ini_profiles.set("core", "selectionPolicy", "1")
 
-        with ini_profiles_path.open("w", encoding="UTF8") as wf:
+        with self.ini_profiles_path.open("w", encoding="UTF8") as wf:
             ini_profiles.write(wf, space_around_delimiters=False)
             logger.info(f"Default profile set to {self.options.get('profile')}")
-
-        logger.debug(f"Job {self.ID} ran successfully.")
diff --git a/qgis_deployment_toolbelt/utils/win32utils.py b/qgis_deployment_toolbelt/utils/win32utils.py
index d1f2c87c..dbdc4894 100644
--- a/qgis_deployment_toolbelt/utils/win32utils.py
+++ b/qgis_deployment_toolbelt/utils/win32utils.py
@@ -20,6 +20,7 @@
 from os import sep  # required since pathlib strips trailing whitespace
 from pathlib import Path
 from sys import platform as opersys
+from typing import Literal
 
 # Imports depending on operating system
 if opersys == "win32":
@@ -39,11 +40,19 @@
 
 if opersys == "win32":
     """windows"""
-    system_hkey = (
+    env_system_hkey = (
         winreg.HKEY_LOCAL_MACHINE,
         r"SYSTEM\CurrentControlSet\Control\Session Manager\Environment",
     )
-    user_hkey = (winreg.HKEY_CURRENT_USER, r"Environment")
+    env_user_hkey = (winreg.HKEY_CURRENT_USER, r"Environment")
+    qgis_command_system_hkey = (
+        winreg.HKEY_LOCAL_MACHINE,
+        r"QGIS Project\Shell\open\command",
+    )
+    qgis_command_user_hkey = (
+        winreg.HKEY_CURRENT_USER,
+        r"Software\Classes\QGIS Project\Shell\open\command",
+    )
 
 
 # #############################################################################
@@ -115,9 +124,9 @@ def delete_environment_variable(envvar_name: str, scope: str = "user") -> bool:
     """
     # user or system
     if scope == "user":
-        hkey = user_hkey
+        hkey = env_user_hkey
     else:
-        hkey = system_hkey
+        hkey = env_system_hkey
 
     # get it to check if variable exits
     try:
@@ -150,9 +159,9 @@ def get_environment_variable(envvar_name: str, scope: str = "user") -> str | Non
     """
     # user or system
     if scope == "user":
-        hkey = user_hkey
+        hkey = env_user_hkey
     else:
-        hkey = system_hkey
+        hkey = env_system_hkey
 
     # try to get the value
     try:
@@ -281,9 +290,9 @@ def set_environment_variable(
     """
     # user or system
     if scope == "user":
-        hkey = user_hkey
+        hkey = env_user_hkey
     else:
-        hkey = system_hkey
+        hkey = env_system_hkey
 
     # try to set the value
     try:
@@ -298,6 +307,79 @@ def set_environment_variable(
         return False
 
 
+def read_registry_value(
+    key: tuple, value_name: str, access_mode: Literal["read", "write"] = "read"
+) -> str | None:
+    r"""Read a value from the Windows registry.
+    Args:
+        key (tuple): registry key to read from, e.g. (winreg.HKEY_CURRENT_USER, r"Software\Classes\QGIS Project\Shell\open\command")
+        value_name (str): name of the value to read
+        access (str, optional): access mode for the registry key, defaults to read
+    Returns:
+        str | None: the value as a string if found, None if not found or an error occurs
+    """
+    if access_mode == "read":
+        access = winreg.KEY_READ
+    elif access_mode == "write":
+        access = winreg.KEY_WRITE
+
+    try:
+        with winreg.OpenKey(*key, access=access) as reg_key:
+            value, _ = winreg.QueryValueEx(reg_key, value_name)
+        return value
+    except FileNotFoundError:
+        logger.error(f"Registry key {key} or value {value_name} not found.")
+        return None
+    except OSError as err:
+        logger.error(f"Error reading registry key {key}: {err}")
+        return None
+
+
+def set_qgis_command(
+    qgis_cmd: str, scope: str = "user", force_key_creation: bool = False
+) -> bool:
+    """Set QGIS command in Windows registry.
+
+    Args:
+        qgis_path (str): path to QGIS installation folder
+        scope (str, optional): environment variable scope. Must be "user" or "system",
+            defaults to "user". Defaults to "user".
+
+    Returns:
+        bool: True is the variable has been successfully set
+    """
+    # user or system
+    if scope == "user":
+        hkey = qgis_command_user_hkey
+    else:
+        hkey = qgis_command_system_hkey
+
+    if force_key_creation:
+        # ensure the key exists
+        try:
+            with winreg.CreateKeyEx(*hkey, access=winreg.KEY_WRITE) as key:
+                pass  # just create the key if it does not exist
+        except OSError as err:
+            logger.error(
+                f"Create QGIS command registry key for scope '{scope}' failed. Trace: {err}"
+            )
+            return False
+
+    # try to set the value
+    try:
+        with winreg.OpenKey(*hkey, access=winreg.KEY_WRITE) as key:
+            winreg.SetValueEx(key, "", 0, winreg.REG_SZ, qgis_cmd)
+        return True
+    except FileNotFoundError:
+        logger.error(f"Registry key {hkey} not found. Is QGIS installed?")
+        return False
+    except OSError as err:
+        logger.error(
+            f"Set QGIS command '{qgis_cmd}' to scope '{scope}' failed. Trace: {err}"
+        )
+        return False
+
+
 # #############################################################################
 # ##### Stand alone program ########
 # ##################################
diff --git a/tests/test_job_default_profile_setter.py b/tests/test_job_default_profile_setter.py
index 675d6c84..28124c43 100644
--- a/tests/test_job_default_profile_setter.py
+++ b/tests/test_job_default_profile_setter.py
@@ -17,13 +17,21 @@
 # Standard library
 import tempfile
 import unittest
+from os import environ, getenv
 from pathlib import Path
+from sys import platform as opersys
 
 # package
 from qgis_deployment_toolbelt.jobs.job_default_profile_setter import (
     JobDefaultProfileSetter,
 )
 
+if opersys == "win32":
+    from qgis_deployment_toolbelt.utils.win32utils import (
+        qgis_command_user_hkey,
+        read_registry_value,
+    )
+
 
 # #############################################################################
 # ########## Classes ###############
@@ -115,3 +123,50 @@ def test_job_default_profile_setter_run_with_force_profile_selection_policy(self
             "[core]\ndefaultProfile=qdt_test_profile_minimal\nselectionPolicy=1\n\n"
         )
         self.assertEqual(content, expected_content)
+
+    @unittest.skipUnless(
+        opersys == "win32" and getenv("GITHUB_ACTIONS", False),
+        "Test specific to Windows and run only in CI to avoid modifying registry.",
+    )
+    def test_job_default_profile_setter_run_with_force_profile_file_association(self):
+        """Run the job with force profile file association."""
+        self.default_profile_setter_job.options["force_profile_file_association"] = True
+        self.default_profile_setter_job.options["force_registry_key_creation"] = True
+        environ["QDT_QGIS_EXE_PATH"] = "/usr/bin/toto"
+
+        self.default_profile_setter_job.run()
+        self.assertTrue(self.profiles_ini.exists())
+
+        reg_value = read_registry_value(
+            qgis_command_user_hkey,
+            "",
+        )
+        expected_reg_value = (
+            '"\\usr\\bin\\toto" --profile "qdt_test_profile_minimal" "%1"'
+        )
+        self.assertEqual(reg_value, expected_reg_value)
+
+    @unittest.skipUnless(
+        opersys == "win32" and getenv("GITHUB_ACTIONS", False),
+        "Test specific to Windows and run only in CI to avoid modifying registry.",
+    )
+    def test_job_default_profile_setter_run_with_profile_file_association_arguments(
+        self,
+    ):
+        """Run the job with force profile file association."""
+        self.default_profile_setter_job.options["force_profile_file_association"] = True
+        self.default_profile_setter_job.options["force_registry_key_creation"] = True
+        self.default_profile_setter_job.options[
+            "profile_file_association_arguments"
+        ] = "--noversioncheck"
+        environ["QDT_QGIS_EXE_PATH"] = "/usr/bin/toto"
+
+        self.default_profile_setter_job.run()
+        self.assertTrue(self.profiles_ini.exists())
+
+        reg_value = read_registry_value(
+            qgis_command_user_hkey,
+            "",
+        )
+        expected_reg_value = '"\\usr\\bin\\toto" --profile "qdt_test_profile_minimal" --noversioncheck "%1"'
+        self.assertEqual(reg_value, expected_reg_value)
diff --git a/tests/test_utils_win32.py b/tests/test_utils_win32.py
index fc8b5c25..35d4f2d9 100644
--- a/tests/test_utils_win32.py
+++ b/tests/test_utils_win32.py
@@ -14,8 +14,17 @@
 import unittest
 from sys import platform as opersys
 
+# Imports depending on operating system
+if opersys == "win32":
+    """windows"""
+    # standard
+    import winreg
+
 # project
-from qgis_deployment_toolbelt.utils.win32utils import get_environment_variable
+from qgis_deployment_toolbelt.utils.win32utils import (
+    get_environment_variable,
+    read_registry_value,
+)
 
 # ############################################################################
 # ########## Classes #############
@@ -34,6 +43,32 @@ def test_win32_getenv(self):
         # KO
         self.assertIsNone(get_environment_variable("YOUPI"))
 
+    @unittest.skipUnless(opersys == "win32", "Test specific to Windows.")
+    def test_win32_read_registry_value(self):
+        """Test specific Windows registry value reader."""
+        # OK
+        self.assertIsInstance(
+            read_registry_value(
+                (
+                    winreg.HKEY_LOCAL_MACHINE,
+                    r"SOFTWARE\Microsoft\Windows NT\CurrentVersion",
+                ),
+                "ProductName",
+            ),
+            str,
+        )
+
+        # KO
+        self.assertIsNone(
+            read_registry_value(
+                (
+                    winreg.HKEY_CURRENT_USER,
+                    r"Software\Microsoft\Windows\CurrentVersion\Explorer",
+                ),
+                "NonExistentKey",
+            )
+        )
+
 
 # ############################################################################
 # ####### Stand-alone run ########