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I think this is LaTeX problem directly. Quarto defaults to xelatex and this is what causes the issue.

If you set pdf-engine: pdflatex it works

---
title: "Reproducible Quarto Document"
format: 
  pdf:
    pdf-engine: pdflatex
---


 
...two types of associations between $X$ and $Y$, with and without conditioning on a third variable, $Z$. In the top panels, $X$ and $Y$ are marginally dependent (i.e., $X  \not\!\perp\!\!\!\perp Y$), but become independent when we condition on $Z$ (i.e., $X \perp\!\!\!\perp Y | Z$).  

So I would look into why this specific latex equation syntax for xelatex or lualatex engine.

Using pandoc -t pdf -f markdown -o test.pdf --pdf-engine=xelatex test.qmd gives me …

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@jfieberg
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