diff --git a/news/changelog-1.6.md b/news/changelog-1.6.md
index d6f820934fb..1743764ed19 100644
--- a/news/changelog-1.6.md
+++ b/news/changelog-1.6.md
@@ -75,6 +75,7 @@ All changes included in 1.6:
 
 ### Websites
 
+- ([#2671](https://github.com/quarto-dev/quarto-cli/issues/2671)): Ensure that `--output-dir` works across filesystem boundaries.
 - ([#8932](https://github.com/quarto-dev/quarto-cli/issues/8932)): Escape render ids in markdown pipeline to allow special characters in sidebars/navbars, etc.
 - ([#10616](https://github.com/quarto-dev/quarto-cli/issues/10268)): Add a `z-index` setting to the 'back to top' button to ensure it is always visible.
 
diff --git a/src/command/render/project.ts b/src/command/render/project.ts
index a808e02cc7a..76fbbeb175d 100644
--- a/src/command/render/project.ts
+++ b/src/command/render/project.ts
@@ -4,7 +4,7 @@
  * Copyright (C) 2020-2022 Posit Software, PBC
  */
 
-import { ensureDirSync, existsSync } from "../../deno_ral/fs.ts";
+import { ensureDirSync, existsSync, safeMoveSync } from "../../deno_ral/fs.ts";
 import { dirname, isAbsolute, join, relative } from "../../deno_ral/path.ts";
 import { info, warning } from "../../deno_ral/log.ts";
 import { mergeProjectMetadata } from "../../config/metadata.ts";
@@ -530,7 +530,7 @@ export async function renderProject(
       if (!renderedFile.isTransient) {
         const outputFile = join(formatOutputDir, renderedFile.file);
         ensureDirSync(dirname(outputFile));
-        Deno.renameSync(join(projDir, renderedFile.file), outputFile);
+        safeMoveSync(join(projDir, renderedFile.file), outputFile);
       }
 
       // files dir
diff --git a/src/core/path.ts b/src/core/path.ts
index 75331568464..a10fa62926e 100644
--- a/src/core/path.ts
+++ b/src/core/path.ts
@@ -18,7 +18,9 @@ import {
 
 import { warning } from "../deno_ral/log.ts";
 
-import { existsSync, expandGlobSync } from "../deno_ral/fs.ts";
+export { safeRemoveSync } from "../deno_ral/fs.ts";
+
+import { existsSync, expandGlobSync, safeRemoveSync } from "../deno_ral/fs.ts";
 
 import * as ld from "./lodash.ts";
 
@@ -41,19 +43,6 @@ export function safeRemoveIfExists(file: string) {
   }
 }
 
-export function safeRemoveSync(
-  file: string,
-  options: Deno.RemoveOptions = {},
-) {
-  try {
-    Deno.removeSync(file, options);
-  } catch (e) {
-    if (existsSync(file)) {
-      throw e;
-    }
-  }
-}
-
 export function removeIfEmptyDir(dir: string): boolean {
   if (existsSync(dir)) {
     let empty = true;
diff --git a/src/deno_ral/fs.ts b/src/deno_ral/fs.ts
index ca640075c98..cf229454518 100644
--- a/src/deno_ral/fs.ts
+++ b/src/deno_ral/fs.ts
@@ -6,6 +6,8 @@
 
 import { fromFileUrl } from "./path.ts";
 import { resolve, SEP as SEPARATOR } from "./path.ts";
+import { copySync } from "fs/copy";
+import { existsSync } from "fs/exists";
 
 export { ensureDir, ensureDirSync } from "fs/ensure-dir";
 export { existsSync } from "fs/exists";
@@ -74,3 +76,31 @@ export function toPathString(
 ): string {
   return pathUrl instanceof URL ? fromFileUrl(pathUrl) : pathUrl;
 }
+
+export function safeMoveSync(
+  src: string,
+  dest: string,
+): void {
+  try {
+    Deno.renameSync(src, dest);
+  } catch (err) {
+    if (err.code !== "EXDEV") {
+      throw err;
+    }
+    copySync(src, dest, { overwrite: true });
+    safeRemoveSync(src, { recursive: true });
+  }
+}
+
+export function safeRemoveSync(
+  file: string,
+  options: Deno.RemoveOptions = {},
+) {
+  try {
+    Deno.removeSync(file, options);
+  } catch (e) {
+    if (existsSync(file)) {
+      throw e;
+    }
+  }
+}