diff --git a/jest.config.js b/jest.config.js
index 8678d5c..776ec03 100644
--- a/jest.config.js
+++ b/jest.config.js
@@ -1,6 +1,9 @@
-/** @type {import('ts-jest').JestConfigWithTsJest} **/
+/** @type {import('ts-jest').ProjectConfigTsJest} **/
 module.exports = {
     testEnvironment: 'jsdom',
+    "setupFilesAfterEnv": [
+      "<rootDir>/test-setup.js"
+    ],
     transform: {
       '^.+.tsx?$': [
         'ts-jest',
diff --git a/src/file-selector.spec.ts b/src/file-selector.spec.ts
index 2493ece..412420e 100644
--- a/src/file-selector.spec.ts
+++ b/src/file-selector.spec.ts
@@ -304,6 +304,64 @@ it('should use getAsFileSystemHandle when available', async () => {
     expect(file.path).toBe(`./${name}`);
 });
 
+it('should not use getAsFileSystemHandle when not in a secure context', async () => {
+    const f1Name = 'test.nosec.json';
+    const f1 = createFile(f1Name, {ping: false}, {
+        type: 'application/json'
+    });
+    const [_, h] = createFileSystemFileHandle('test.sec.json', {ping: true}, {
+        type: 'application/json'
+    });
+    const evt = dragEvtFromItems([
+        dataTransferItemWithFsHandle(f1, h)
+    ]);
+
+    window.isSecureContext = false;
+
+    const files = await fromEvent(evt);
+    expect(files).toHaveLength(1);
+    expect(files.every(file => file instanceof File)).toBe(true);
+
+    const [file] = files as FileWithPath[];
+
+    expect(file.name).toBe(f1.name);
+    expect(file.type).toBe(f1.type);
+    expect(file.size).toBe(f1.size);
+    expect(file.lastModified).toBe(f1.lastModified);
+    expect(file.path).toBe(`./${f1Name}`);
+
+    window.isSecureContext = true;
+});
+
+it('should reject when getAsFileSystemHandle resolves to null', async () => {
+    const evt = dragEvtFromItems([
+        dataTransferItemWithFsHandle(null, null)
+    ]);
+    expect(fromEvent(evt)).rejects.toThrow('[object Object] is not a File');
+});
+
+it('should fallback to getAsFile when getAsFileSystemHandle resolves to undefined', async () => {
+    const name = 'test.nosec.json';
+    const mockFile = createFile(name, {ping: false}, {
+        type: 'application/json'
+    });
+    const evt = dragEvtFromItems([
+        dataTransferItemWithFsHandle(mockFile, undefined)
+    ]);
+
+    const files = await fromEvent(evt);
+    expect(files).toHaveLength(1);
+    expect(files.every(file => file instanceof File)).toBe(true);
+
+    const [file] = files as FileWithPath[];
+
+    expect(file.name).toBe(mockFile.name);
+    expect(file.type).toBe(mockFile.type);
+    expect(file.size).toBe(mockFile.size);
+    expect(file.lastModified).toBe(mockFile.lastModified);
+    expect(file.path).toBe(`./${name}`);
+});
+
 function dragEvtFromItems(items: DataTransferItem | DataTransferItem[], type: string = 'drop'): DragEvent {
     return {
         type,
@@ -374,7 +432,7 @@ function dataTransferItemFromEntry(entry: FileEntry | DirEntry, file?: File): Da
     } as any;
 }
 
-function dataTransferItemWithFsHandle(file?: File, h?: FileSystemFileHandle): DataTransferItem {
+function dataTransferItemWithFsHandle(file?: File | null, h?: FileSystemFileHandle | null): DataTransferItem {
     return {
         kind: 'file',
         getAsFile() {
@@ -466,8 +524,7 @@ function createFile<T>(name: string, data: T, options?: FilePropertyBag) {
 }
 
 function createFileSystemFileHandle<T>(name: string, data: T, options?: FilePropertyBag): [File, FileSystemFileHandle] {
-    const json = JSON.stringify(data);
-    const file = new File([json], name, options);
+    const file = createFile(name, data, options);
     return [file, {
         getFile() {
             return Promise.resolve(file);
@@ -482,7 +539,7 @@ function sortFiles<T extends File>(files: T[]) {
 
 
 interface FileSystemFileHandle {
-    getFile(): Promise<File>;
+    getFile(): Promise<File | null>;
 }
 
 type FileOrDirEntry = FileEntry | DirEntry
diff --git a/src/file-selector.ts b/src/file-selector.ts
index 4aaee19..33717d7 100644
--- a/src/file-selector.ts
+++ b/src/file-selector.ts
@@ -120,21 +120,32 @@ function flatten<T>(items: any[]): T[] {
     ], []);
 }
 
-function fromDataTransferItem(item: DataTransferItem, entry?: FileSystemEntry | null) {
-    if (typeof (item as any).getAsFileSystemHandle === 'function') {
-        return (item as any).getAsFileSystemHandle()
-            .then(async (h: any) => {
-                const file = await h.getFile();
-                file.handle = h;
-                return toFileWithPath(file);
-            });
+async function fromDataTransferItem(item: DataTransferItem, entry?: FileSystemEntry | null) {
+    // Check if we're in a secure context; due to a bug in Chrome (as far as we know)
+    // the browser crashes when calling this API (yet to be confirmed as a consistent behaviour).
+    //
+    // See:
+    // - https://issues.chromium.org/issues/40186242
+    // - https://github.com/react-dropzone/react-dropzone/issues/1397
+    if (globalThis.isSecureContext && typeof (item as any).getAsFileSystemHandle === 'function') {
+        const h = await (item as any).getAsFileSystemHandle();
+        if (h === null) {
+            throw new Error(`${item} is not a File`);
+        }
+        // It seems that the handle can be `undefined` (see https://github.com/react-dropzone/file-selector/issues/120),
+        // so we check if it isn't; if it is, the code path continues to the next API (`getAsFile`).
+        if (h !== undefined) {
+            const file = await h.getFile();
+            file.handle = h;
+            return toFileWithPath(file);
+        }
     }
     const file = item.getAsFile();
     if (!file) {
-        return Promise.reject(`${item} is not a File`);
+        throw new Error(`${item} is not a File`);
     }
     const fwp = toFileWithPath(file, entry?.fullPath ?? undefined);
-    return Promise.resolve(fwp);
+    return fwp;
 }
 
 // https://developer.mozilla.org/en-US/docs/Web/API/FileSystemEntry
diff --git a/test-setup.js b/test-setup.js
new file mode 100644
index 0000000..671e925
--- /dev/null
+++ b/test-setup.js
@@ -0,0 +1,6 @@
+// NOTE: Let us test {isSecureContext}!
+Object.defineProperty(globalThis, "isSecureContext", {
+  value: true,
+  writable: true,
+  enumerable: true,
+});