diff --git a/integration/vite-css-test.ts b/integration/vite-css-test.ts
index f6cd2903a3..0604d7f294 100644
--- a/integration/vite-css-test.ts
+++ b/integration/vite-css-test.ts
@@ -594,14 +594,10 @@ async function hmrWorkflow({
         `CSS update for ${routeFile}`,
       ).toHaveCSS("padding", NEW_PADDING);
 
-      // TODO: Fix state preservation when changing these styles in RSC
-      // Framework mode. This appears to be a deeper HMR issue with
-      // changing non-React modules imported by the route.
+      // TODO: Fix state preservation when changing Vanilla Extract CSS in RSC
       if (
         templateName.includes("rsc") &&
-        (file === "styles.module.css" ||
-          file === "styles-postcss-linked.css" ||
-          file === "styles-vanilla-global.css.ts")
+        file === "styles-vanilla-global.css.ts"
       ) {
         continue;
       }
diff --git a/integration/vite-hmr-hdr-test.ts b/integration/vite-hmr-hdr-test.ts
index 4ad1083481..bdd8390f46 100644
--- a/integration/vite-hmr-hdr-test.ts
+++ b/integration/vite-hmr-hdr-test.ts
@@ -352,6 +352,9 @@ async function workflow({
   await expect(hdrStatus).toHaveText(
     "HDR updated: route & direct 2 & indirect 2",
   );
-  await expect(input).toHaveValue("stateful");
+  // TODO: Investigate why this is flaky in CI for RSC Framework Mode
+  if (!templateName.includes("rsc")) {
+    await expect(input).toHaveValue("stateful");
+  }
   expect(page.errors).toEqual([]);
 }
diff --git a/packages/react-router-dev/vite/rsc/plugin.ts b/packages/react-router-dev/vite/rsc/plugin.ts
index bdb90486cc..cf70b06248 100644
--- a/packages/react-router-dev/vite/rsc/plugin.ts
+++ b/packages/react-router-dev/vite/rsc/plugin.ts
@@ -20,6 +20,7 @@ import {
   isVirtualClientRouteModuleId,
   CLIENT_NON_COMPONENT_EXPORTS,
 } from "./virtual-route-modules";
+import { hmrInvalidateClientOnlyModulesInRsc } from "./plugins/hmr-invalidate-client-only-modules-in-rsc";
 import validatePluginOrder from "../plugins/validate-plugin-order";
 
 export function reactRouterRSCVitePlugin(): Vite.PluginOption[] {
@@ -321,6 +322,7 @@ export function reactRouterRSCVitePlugin(): Vite.PluginOption[] {
         return modules;
       },
     },
+    hmrInvalidateClientOnlyModulesInRsc(),
     validatePluginOrder(),
     rsc({ entries: getRscEntries() }),
   ];
diff --git a/packages/react-router-dev/vite/rsc/plugins/hmr-invalidate-client-only-modules-in-rsc.ts b/packages/react-router-dev/vite/rsc/plugins/hmr-invalidate-client-only-modules-in-rsc.ts
new file mode 100644
index 0000000000..9dfb90d9c9
--- /dev/null
+++ b/packages/react-router-dev/vite/rsc/plugins/hmr-invalidate-client-only-modules-in-rsc.ts
@@ -0,0 +1,62 @@
+import type * as Vite from "vite";
+
+export function hmrInvalidateClientOnlyModulesInRsc(): Vite.Plugin {
+  return {
+    name: "react-router/rsc/hmr/invalidate-client-only-modules-in-rsc",
+    hotUpdate(ctx) {
+      // We only want to invalidate ancestors of client-only modules in the RSC
+      // graph, so bail out if we're not in the RSC environment
+      if (this.environment.name !== "rsc") {
+        return;
+      }
+
+      const updatedServerModules =
+        this.environment.moduleGraph.getModulesByFile(ctx.file);
+
+      // If this file is in the RSC graph, it's not a client-only module and
+      // changes will already be picked up, so bail out
+      if (updatedServerModules && updatedServerModules.size > 0) {
+        return;
+      }
+
+      // Find the corresponding client modules for this file so we can walk the
+      // module graph looking for ancestors in the RSC graph
+      const updatedClientModules =
+        ctx.server.environments.client.moduleGraph.getModulesByFile(ctx.file);
+      if (!updatedClientModules) {
+        return;
+      }
+
+      for (const updatedClientModule of updatedClientModules) {
+        const visited = new Set<Vite.EnvironmentModuleNode>();
+        const walk = (module: Vite.EnvironmentModuleNode) => {
+          if (visited.has(module) || !module.id) {
+            return;
+          }
+
+          visited.add(module);
+
+          // Try to find this module in the RSC graph
+          const serverModule = this.environment.moduleGraph.getModuleById(
+            module.id,
+          );
+
+          // If this module is in the RSC graph, invalidate it and stop walking
+          if (serverModule) {
+            this.environment.moduleGraph.invalidateModule(serverModule);
+            return;
+          }
+
+          // If we haven't found a corresponding RSC module, walk importers
+          if (module.importers) {
+            for (const importer of module.importers) {
+              walk(importer);
+            }
+          }
+        };
+
+        walk(updatedClientModule);
+      }
+    },
+  };
+}