diff --git a/src/TailwindCSSRspackPlugin.ts b/src/TailwindCSSRspackPlugin.ts
index e49ec71..4dd17cd 100644
--- a/src/TailwindCSSRspackPlugin.ts
+++ b/src/TailwindCSSRspackPlugin.ts
@@ -116,6 +116,32 @@ interface TailwindRspackPluginOptions {
    */
   include?: FilterPattern | undefined;
 
+  /**
+   * Setting Tailwind config path for different entries
+   *
+   * {@link multipleConfig} can be configured as an object where the key is the entryName and the value is the config path.
+   * If the key cannot be found, it will fallback to {@link config} , which is the default config path.
+   *
+   * @example
+   *
+   * ```js
+   * // rspack.config.js
+   * import { TailwindRspackPlugin } from 'rsbuild-plugin-tailwindcss'
+   *
+   * export default {
+   *   plugins: [
+   *     new TailwindRspackPlugin({
+   *        multipleConfig: {
+   *          index: './config/tailwind.index.config.js',
+   *          main: './config/tailwind.main.config.js'
+   *        },
+   *     }),
+   *   ],
+   * }
+   * ```
+   */
+  multipleConfig?: Record<string, string> | undefined;
+
   /**
    * The postcss options to be applied.
    *
@@ -315,10 +341,14 @@ class TailwindRspackPluginImpl {
     entryName: string,
     entryModules: Array<string>,
   ): Promise<string> {
-    const userConfig = path.isAbsolute(this.options.config)
-      ? this.options.config
+    const multipleConfig = this.options.multipleConfig || {};
+
+    const userConfig = multipleConfig[entryName] || this.options.config;
+
+    const resolvedConfig = path.isAbsolute(userConfig)
+      ? userConfig
       : // biome-ignore lint/style/noNonNullAssertion: should have context
-        path.resolve(this.compiler.options.context!, this.options.config);
+        path.resolve(this.compiler.options.context!, userConfig);
 
     const outputDir = DEBUG
       ? path.resolve(
@@ -334,7 +364,7 @@ class TailwindRspackPluginImpl {
     }
 
     const [configName, configContent] = await this.#generateTailwindConfig(
-      userConfig,
+      resolvedConfig,
       entryModules,
     );
     const configPath = path.resolve(outputDir, configName);
diff --git a/src/index.ts b/src/index.ts
index 57d9673..70c1892 100644
--- a/src/index.ts
+++ b/src/index.ts
@@ -112,6 +112,32 @@ export interface PluginTailwindCSSOptions {
    * ```
    */
   include?: FilterPattern | undefined;
+
+  /**
+   * Setting Tailwind config path for different entries
+   *
+   * {@link multipleConfig} can be configured as an object where the key is the entryName and the value is the config path.
+   * If the key cannot be found, it will fallback to {@link config} , which is the default config path.
+   *
+   * @example
+   *
+   * ```js
+   * // rspack.config.js
+   * import { TailwindRspackPlugin } from 'rsbuild-plugin-tailwindcss'
+   *
+   * export default {
+   *   plugins: [
+   *     new TailwindRspackPlugin({
+   *        multipleConfig: {
+   *          index: './config/tailwind.index.config.js',
+   *          main: './config/tailwind.main.config.js'
+   *        },
+   *     }),
+   *   ],
+   * }
+   * ```
+   */
+  multipleConfig?: Record<string, string> | undefined;
 }
 
 export const pluginTailwindCSS = (
@@ -160,6 +186,7 @@ export const pluginTailwindCSS = (
             config: options.config ?? 'tailwind.config.js',
             include: options.include,
             exclude: options.exclude,
+            multipleConfig: options.multipleConfig,
             postcssOptions,
           },
         ]);
diff --git a/test/multiple-config/config/tailwind.index.config.js b/test/multiple-config/config/tailwind.index.config.js
new file mode 100644
index 0000000..f151588
--- /dev/null
+++ b/test/multiple-config/config/tailwind.index.config.js
@@ -0,0 +1,11 @@
+/** @type {import('tailwindcss').Config} */
+export default {
+  content: ['./src/**/*.{js,jsx,ts,tsx}'],
+  theme: {
+    extend: {
+      colors: {
+        index: '#0055ff',
+      },
+    },
+  },
+};
diff --git a/test/multiple-config/config/tailwind.main.config.js b/test/multiple-config/config/tailwind.main.config.js
new file mode 100644
index 0000000..425d438
--- /dev/null
+++ b/test/multiple-config/config/tailwind.main.config.js
@@ -0,0 +1,11 @@
+/** @type {import('tailwindcss').Config} */
+export default {
+  content: ['./src/**/*.{js,jsx,ts,tsx}'],
+  theme: {
+    extend: {
+      colors: {
+        main: '#ff5500',
+      },
+    },
+  },
+};
diff --git a/test/multiple-config/index.test.ts b/test/multiple-config/index.test.ts
new file mode 100644
index 0000000..1c5410d
--- /dev/null
+++ b/test/multiple-config/index.test.ts
@@ -0,0 +1,68 @@
+import { dirname } from 'node:path';
+import { fileURLToPath } from 'node:url';
+
+import test, { expect } from '@playwright/test';
+import { createRsbuild } from '@rsbuild/core';
+
+import { pluginTailwindCSS } from '../../src';
+import { getRandomPort } from '../helper';
+
+const __dirname = dirname(fileURLToPath(import.meta.url));
+
+test('should build with multiple configs for different entries', async ({
+  page,
+}) => {
+  const rsbuild = await createRsbuild({
+    cwd: __dirname,
+    rsbuildConfig: {
+      source: {
+        entry: {
+          index: './src/index.js',
+          main: './src/main.js',
+          default: './src/default.js',
+        },
+      },
+      plugins: [
+        pluginTailwindCSS({
+          multipleConfig: {
+            index: './config/tailwind.index.config.js',
+            main: './config/tailwind.main.config.js',
+          },
+        }),
+      ],
+      server: {
+        port: getRandomPort(),
+      },
+    },
+  });
+
+  await rsbuild.build();
+
+  const { server, urls } = await rsbuild.startDevServer();
+
+  await page.goto(`${urls[0]}/index`);
+  let style = await getStyle();
+  expect(style.backgroundColor).toBe('rgb(0, 85, 255)');
+
+  await page.goto(`${urls[0]}/main`);
+  style = await getStyle();
+  expect(style.backgroundColor).toBe('rgb(255, 85, 0)');
+
+  await page.goto(`${urls[0]}/default`);
+  style = await getStyle();
+  expect(style.backgroundColor).toBe('rgb(85, 255, 0)');
+
+  await server.close();
+
+  async function getStyle() {
+    return await page.evaluate(() => {
+      const el = document.getElementById('test');
+
+      if (!el) {
+        throw new Error('#test not found');
+      }
+
+      return window.getComputedStyle(el);
+    });
+  }
+});
diff --git a/test/multiple-config/src/default.js b/test/multiple-config/src/default.js
new file mode 100644
index 0000000..7ceeb48
--- /dev/null
+++ b/test/multiple-config/src/default.js
@@ -0,0 +1,12 @@
+import 'tailwindcss/utilities.css';
+
+function className() {
+  return 'flex bg-default';
+}
+
+const root = document.getElementById('root');
+const element = document.createElement('div');
+element.id = 'test';
+element.className = className();
+element.textContent = 'Default Entry';
+root.appendChild(element);
diff --git a/test/multiple-config/src/index.js b/test/multiple-config/src/index.js
new file mode 100644
index 0000000..4369bd8
--- /dev/null
+++ b/test/multiple-config/src/index.js
@@ -0,0 +1,12 @@
+import 'tailwindcss/utilities.css';
+
+function className() {
+  return 'flex bg-index';
+}
+
+const root = document.getElementById('root');
+const element = document.createElement('div');
+element.id = 'test';
+element.className = className();
+element.textContent = 'Index Entry';
+root.appendChild(element);
diff --git a/test/multiple-config/src/main.js b/test/multiple-config/src/main.js
new file mode 100644
index 0000000..5f12715
--- /dev/null
+++ b/test/multiple-config/src/main.js
@@ -0,0 +1,12 @@
+import 'tailwindcss/utilities.css';
+
+function className() {
+  return 'flex bg-main';
+}
+
+const root = document.getElementById('root');
+const element = document.createElement('div');
+element.id = 'test';
+element.className = className();
+element.textContent = 'Main Entry';
+root.appendChild(element);
diff --git a/test/multiple-config/tailwind.config.js b/test/multiple-config/tailwind.config.js
new file mode 100644
index 0000000..2595b0f
--- /dev/null
+++ b/test/multiple-config/tailwind.config.js
@@ -0,0 +1,11 @@
+/** @type {import('tailwindcss').Config} */
+export default {
+  content: ['./src/**/*.{js,jsx,ts,tsx}'],
+  theme: {
+    extend: {
+      colors: {
+        default: '#55ff00',
+      },
+    },
+  },
+};