diff --git a/Cargo.toml b/Cargo.toml
index d1428a77d..cb0634511 100644
--- a/Cargo.toml
+++ b/Cargo.toml
@@ -21,7 +21,7 @@ bio-types = ">=0.9"
 byteorder = "1.3"
 custom_derive = "0.1"
 derive-new = "0.7"
-hts-sys = {version = "2.1.4", default-features = false, features = ["bindgen"]}
+hts-sys = {version = "2.2.0", default-features = false, features = ["bindgen"]}
 ieee754 = "0.2"
 lazy_static = "1.4"
 libc = "0.2"