diff --git a/CHANGELOG.md b/CHANGELOG.md
index 30781d3d33fb..d3c30065e866 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -6759,6 +6759,7 @@ Released 2018-09-13
 [`unsafe_removed_from_name`]: https://rust-lang.github.io/rust-clippy/master/index.html#unsafe_removed_from_name
 [`unsafe_vector_initialization`]: https://rust-lang.github.io/rust-clippy/master/index.html#unsafe_vector_initialization
 [`unseparated_literal_suffix`]: https://rust-lang.github.io/rust-clippy/master/index.html#unseparated_literal_suffix
+[`unsigned_subtraction_gt_zero`]: https://rust-lang.github.io/rust-clippy/master/index.html#unsigned_subtraction_gt_zero
 [`unsound_collection_transmute`]: https://rust-lang.github.io/rust-clippy/master/index.html#unsound_collection_transmute
 [`unstable_as_mut_slice`]: https://rust-lang.github.io/rust-clippy/master/index.html#unstable_as_mut_slice
 [`unstable_as_slice`]: https://rust-lang.github.io/rust-clippy/master/index.html#unstable_as_slice
diff --git a/clippy_lints/src/declared_lints.rs b/clippy_lints/src/declared_lints.rs
index 0ec0aaaad453..01de75f442cd 100644
--- a/clippy_lints/src/declared_lints.rs
+++ b/clippy_lints/src/declared_lints.rs
@@ -600,6 +600,7 @@ pub static LINTS: &[&::declare_clippy_lint::LintInfo] = &[
     crate::operators::OP_REF_INFO,
     crate::operators::REDUNDANT_COMPARISONS_INFO,
     crate::operators::SELF_ASSIGNMENT_INFO,
+    crate::operators::UNSIGNED_SUBTRACTION_GT_ZERO_INFO,
     crate::operators::VERBOSE_BIT_MASK_INFO,
     crate::option_env_unwrap::OPTION_ENV_UNWRAP_INFO,
     crate::option_if_let_else::OPTION_IF_LET_ELSE_INFO,
diff --git a/clippy_lints/src/operators/mod.rs b/clippy_lints/src/operators/mod.rs
index aaea4ff11fc3..3feaeb267057 100644
--- a/clippy_lints/src/operators/mod.rs
+++ b/clippy_lints/src/operators/mod.rs
@@ -20,6 +20,7 @@ mod needless_bitwise_bool;
 mod numeric_arithmetic;
 mod op_ref;
 mod self_assignment;
+mod unsigned_subtraction_gt_zero;
 mod verbose_bit_mask;
 
 pub(crate) mod arithmetic_side_effects;
@@ -62,6 +63,34 @@ declare_clippy_lint! {
     "a comparison with a maximum or minimum value that is always true or false"
 }
 
+declare_clippy_lint! {
+    /// ### What it does
+    /// Lints comparisons of an unsigned integer subtraction against zero, like `(a - b) > 0`.
+    ///
+    /// ### Why is this bad?
+    /// If `a < b`, `a - b` will panic in debug builds and wrap in release builds, making the
+    /// comparison effectively behave like `a != b`. This is likely unintended; `a > b` is clearer
+    /// and avoids potential panics and wraparound.
+    ///
+    /// ### Example
+    /// ```no_run
+    /// let (a, b): (u32, u32) = (1, 2);
+    /// if a - b > 0 {}
+    /// ```
+    ///
+    /// Use instead:
+    /// ```no_run
+    /// let (a, b): (u32, u32) = (1, 2);
+    /// if a > b {}
+    /// // Or, if you meant inequality:
+    /// if a != b {}
+    /// ```
+    #[clippy::version = "1.92.0"]
+    pub UNSIGNED_SUBTRACTION_GT_ZERO,
+    correctness,
+    "suspicious comparison of unsigned subtraction to zero"
+}
+
 declare_clippy_lint! {
     /// ### What it does
     /// Checks any kind of arithmetic operation of any type.
@@ -906,6 +935,7 @@ impl_lint_pass!(Operators => [
     SELF_ASSIGNMENT,
     MANUAL_MIDPOINT,
     MANUAL_IS_MULTIPLE_OF,
+    UNSIGNED_SUBTRACTION_GT_ZERO,
 ]);
 
 impl<'tcx> LateLintPass<'tcx> for Operators {
@@ -932,6 +962,7 @@ impl<'tcx> LateLintPass<'tcx> for Operators {
                 const_comparisons::check(cx, op, lhs, rhs, e.span);
                 duration_subsec::check(cx, e, op.node, lhs, rhs);
                 float_equality_without_abs::check(cx, e, op.node, lhs, rhs);
+                unsigned_subtraction_gt_zero::check(cx, e, op.node, lhs, rhs);
                 integer_division::check(cx, e, op.node, lhs, rhs);
                 cmp_owned::check(cx, op.node, lhs, rhs);
                 float_cmp::check(cx, e, op.node, lhs, rhs);
diff --git a/clippy_lints/src/operators/unsigned_subtraction_gt_zero.rs b/clippy_lints/src/operators/unsigned_subtraction_gt_zero.rs
new file mode 100644
index 000000000000..b6f565d2b928
--- /dev/null
+++ b/clippy_lints/src/operators/unsigned_subtraction_gt_zero.rs
@@ -0,0 +1,64 @@
+use clippy_utils::consts::is_zero_integer_const;
+use clippy_utils::diagnostics::span_lint_and_then;
+use clippy_utils::sugg::Sugg;
+use rustc_errors::Applicability;
+use rustc_hir::{BinOpKind, Expr, ExprKind};
+use rustc_lint::LateContext;
+use rustc_middle::ty;
+
+use super::UNSIGNED_SUBTRACTION_GT_ZERO;
+
+pub(super) fn check<'tcx>(
+    cx: &LateContext<'tcx>,
+    expr: &'tcx Expr<'tcx>,
+    op: BinOpKind,
+    lhs_expr: &'tcx Expr<'tcx>,
+    rhs_expr: &'tcx Expr<'tcx>,
+) {
+    // Avoid linting macro-generated code to reduce noise
+    if expr.span.from_expansion() {
+        return;
+    }
+
+    // Only consider strict relational comparisons where one side is zero and the other is a subtraction
+    let sub_expr = match op {
+        // x > 0
+        BinOpKind::Gt if is_zero_integer_const(cx, rhs_expr, expr.span.ctxt()) => lhs_expr,
+        // 0 < x
+        BinOpKind::Lt if is_zero_integer_const(cx, lhs_expr, expr.span.ctxt()) => rhs_expr,
+
+        _ => return,
+    };
+
+    // Ensure the compared expression is a subtraction
+    let (lhs, rhs) = match sub_expr.kind {
+        ExprKind::Binary(sub_op, lhs, rhs) if sub_op.node == BinOpKind::Sub => (lhs, rhs),
+        _ => return,
+    };
+
+    // Subtraction result type must be an unsigned primitive
+    if !matches!(cx.typeck_results().expr_ty(sub_expr).peel_refs().kind(), ty::Uint(_)) {
+        return;
+    }
+
+    // Suggest `a > b` preserving user formatting with parentheses as needed
+    let mut app = Applicability::MaybeIncorrect;
+    let (left_sugg, right_sugg) = (
+        Sugg::hir_with_applicability(cx, lhs, "_", &mut app).maybe_paren(),
+        Sugg::hir_with_applicability(cx, rhs, "_", &mut app).maybe_paren(),
+    );
+    let replacement = format!("{left_sugg} > {right_sugg}");
+    let neq_suggestion = format!("{left_sugg} != {right_sugg}");
+
+    span_lint_and_then(
+        cx,
+        UNSIGNED_SUBTRACTION_GT_ZERO,
+        expr.span,
+        "suspicious comparison of unsigned subtraction to zero",
+        |diag| {
+            diag.help(format!("`{left_sugg} - {right_sugg} > 0` will panic in debug mode when `{left_sugg} < {right_sugg}` and wrap in release mode; `{left_sugg} > {right_sugg}` is clearer and will never panic"));
+            diag.help(format!("if you meant inequality, use `{neq_suggestion}`"));
+            diag.span_suggestion(expr.span, "try", replacement, app);
+        },
+    );
+}
diff --git a/tests/ui/unsigned_subtraction_gt_zero.fixed b/tests/ui/unsigned_subtraction_gt_zero.fixed
new file mode 100644
index 000000000000..6698956becc0
--- /dev/null
+++ b/tests/ui/unsigned_subtraction_gt_zero.fixed
@@ -0,0 +1,29 @@
+#![warn(clippy::unsigned_subtraction_gt_zero)]
+#![allow(clippy::needless_if)]
+
+fn main() {
+    let (a, b): (u32, u32) = (1, 2);
+    if a > b {}
+    //~^ unsigned_subtraction_gt_zero
+
+    if a > b {}
+    //~^ unsigned_subtraction_gt_zero
+
+    let (x, y): (usize, usize) = (10, 3);
+    if x > y {}
+    //~^ unsigned_subtraction_gt_zero
+
+    if x > y {}
+    //~^ unsigned_subtraction_gt_zero
+
+    // signed: should not lint
+    let (i, j): (i32, i32) = (1, 2);
+    if i - j > 0 {}
+
+    // float: should not lint
+    let (f, g): (f32, f32) = (1.0, 2.0);
+    if f - g > 0.0 {}
+
+    // using saturating_sub: should not lint
+    if a.saturating_sub(b) > 0 {}
+}
diff --git a/tests/ui/unsigned_subtraction_gt_zero.rs b/tests/ui/unsigned_subtraction_gt_zero.rs
new file mode 100644
index 000000000000..0dda9274fe28
--- /dev/null
+++ b/tests/ui/unsigned_subtraction_gt_zero.rs
@@ -0,0 +1,29 @@
+#![warn(clippy::unsigned_subtraction_gt_zero)]
+#![allow(clippy::needless_if)]
+
+fn main() {
+    let (a, b): (u32, u32) = (1, 2);
+    if a - b > 0 {}
+    //~^ unsigned_subtraction_gt_zero
+
+    if 0 < a - b {}
+    //~^ unsigned_subtraction_gt_zero
+
+    let (x, y): (usize, usize) = (10, 3);
+    if x - y > 0 {}
+    //~^ unsigned_subtraction_gt_zero
+
+    if 0 < x - y {}
+    //~^ unsigned_subtraction_gt_zero
+
+    // signed: should not lint
+    let (i, j): (i32, i32) = (1, 2);
+    if i - j > 0 {}
+
+    // float: should not lint
+    let (f, g): (f32, f32) = (1.0, 2.0);
+    if f - g > 0.0 {}
+
+    // using saturating_sub: should not lint
+    if a.saturating_sub(b) > 0 {}
+}
diff --git a/tests/ui/unsigned_subtraction_gt_zero.stderr b/tests/ui/unsigned_subtraction_gt_zero.stderr
new file mode 100644
index 000000000000..1bd227dcd885
--- /dev/null
+++ b/tests/ui/unsigned_subtraction_gt_zero.stderr
@@ -0,0 +1,40 @@
+error: suspicious comparison of unsigned subtraction to zero
+  --> tests/ui/unsigned_subtraction_gt_zero.rs:6:8
+   |
+LL |     if a - b > 0 {}
+   |        ^^^^^^^^^ help: try: `a > b`
+   |
+   = help: `a - b > 0` will panic in debug mode when `a < b` and wrap in release mode; `a > b` is clearer and will never panic
+   = help: if you meant inequality, use `a != b`
+   = note: `-D clippy::unsigned-subtraction-gt-zero` implied by `-D warnings`
+   = help: to override `-D warnings` add `#[allow(clippy::unsigned_subtraction_gt_zero)]`
+
+error: suspicious comparison of unsigned subtraction to zero
+  --> tests/ui/unsigned_subtraction_gt_zero.rs:9:8
+   |
+LL |     if 0 < a - b {}
+   |        ^^^^^^^^^ help: try: `a > b`
+   |
+   = help: `a - b > 0` will panic in debug mode when `a < b` and wrap in release mode; `a > b` is clearer and will never panic
+   = help: if you meant inequality, use `a != b`
+
+error: suspicious comparison of unsigned subtraction to zero
+  --> tests/ui/unsigned_subtraction_gt_zero.rs:13:8
+   |
+LL |     if x - y > 0 {}
+   |        ^^^^^^^^^ help: try: `x > y`
+   |
+   = help: `x - y > 0` will panic in debug mode when `x < y` and wrap in release mode; `x > y` is clearer and will never panic
+   = help: if you meant inequality, use `x != y`
+
+error: suspicious comparison of unsigned subtraction to zero
+  --> tests/ui/unsigned_subtraction_gt_zero.rs:16:8
+   |
+LL |     if 0 < x - y {}
+   |        ^^^^^^^^^ help: try: `x > y`
+   |
+   = help: `x - y > 0` will panic in debug mode when `x < y` and wrap in release mode; `x > y` is clearer and will never panic
+   = help: if you meant inequality, use `x != y`
+
+error: aborting due to 4 previous errors
+