diff --git a/clippy_lints/src/multiple_unsafe_ops_per_block.rs b/clippy_lints/src/multiple_unsafe_ops_per_block.rs
index 80cf081992cc..dd00536c9ef4 100644
--- a/clippy_lints/src/multiple_unsafe_ops_per_block.rs
+++ b/clippy_lints/src/multiple_unsafe_ops_per_block.rs
@@ -119,6 +119,12 @@ impl<'tcx> Visitor<'tcx> for UnsafeExprCollector<'tcx> {
     type NestedFilter = nested_filter::OnlyBodies;
 
     fn visit_expr(&mut self, expr: &'tcx hir::Expr<'tcx>) {
+        if expr.span.in_external_macro(self.tcx.sess.source_map()) {
+            // Check the content of the expanded code to still catch the unsafe
+            // operation passed as macro arguments.
+            return walk_expr(self, expr);
+        }
+
         match expr.kind {
             // The `await` itself will desugar to two unsafe calls, but we should ignore those.
             // Instead, check the expression that is `await`ed
diff --git a/tests/ui/multiple_unsafe_ops_per_block.rs b/tests/ui/multiple_unsafe_ops_per_block.rs
index c1512ba3e269..d73e2673f517 100644
--- a/tests/ui/multiple_unsafe_ops_per_block.rs
+++ b/tests/ui/multiple_unsafe_ops_per_block.rs
@@ -312,4 +312,38 @@ fn check_closures() {
     }
 }
 
+fn issue16116() {
+    unsafe fn foo() -> u32 {
+        0
+    }
+
+    unsafe {
+        // Do not lint even though `format!` expansion
+        // contains unsafe calls.
+        let _ = format!("{}", foo());
+    }
+
+    unsafe {
+        //~^ multiple_unsafe_ops_per_block
+        let _ = format!("{}", foo());
+        let _ = format!("{}", foo());
+    }
+
+    unsafe {
+        // Do not lint: only one `assert!()` argument is unsafe
+        assert!(foo() == 0, "{}", 1 + 2);
+    }
+
+    unsafe {
+        //~^ multiple_unsafe_ops_per_block
+        assert!(foo() == 0, "{}", 1 + 2);
+        assert!(foo() == 0, "{}", 1 + 2);
+    }
+
+    unsafe {
+        //~^ multiple_unsafe_ops_per_block
+        assert!(foo() == 0, "{}", foo());
+    }
+}
+
 fn main() {}
diff --git a/tests/ui/multiple_unsafe_ops_per_block.stderr b/tests/ui/multiple_unsafe_ops_per_block.stderr
index 63f7742b734b..309f53d7f5e9 100644
--- a/tests/ui/multiple_unsafe_ops_per_block.stderr
+++ b/tests/ui/multiple_unsafe_ops_per_block.stderr
@@ -359,5 +359,67 @@ note: unsafe function call occurs here
 LL |         apply(|| f(0));
    |                  ^^^^
 
-error: aborting due to 16 previous errors
+error: this `unsafe` block contains 2 unsafe operations, expected only one
+  --> tests/ui/multiple_unsafe_ops_per_block.rs:326:5
+   |
+LL | /     unsafe {
+LL | |
+LL | |         let _ = format!("{}", foo());
+LL | |         let _ = format!("{}", foo());
+LL | |     }
+   | |_____^
+   |
+note: unsafe function call occurs here
+  --> tests/ui/multiple_unsafe_ops_per_block.rs:328:31
+   |
+LL |         let _ = format!("{}", foo());
+   |                               ^^^^^
+note: unsafe function call occurs here
+  --> tests/ui/multiple_unsafe_ops_per_block.rs:329:31
+   |
+LL |         let _ = format!("{}", foo());
+   |                               ^^^^^
+
+error: this `unsafe` block contains 2 unsafe operations, expected only one
+  --> tests/ui/multiple_unsafe_ops_per_block.rs:337:5
+   |
+LL | /     unsafe {
+LL | |
+LL | |         assert!(foo() == 0, "{}", 1 + 2);
+LL | |         assert!(foo() == 0, "{}", 1 + 2);
+LL | |     }
+   | |_____^
+   |
+note: unsafe function call occurs here
+  --> tests/ui/multiple_unsafe_ops_per_block.rs:339:17
+   |
+LL |         assert!(foo() == 0, "{}", 1 + 2);
+   |                 ^^^^^
+note: unsafe function call occurs here
+  --> tests/ui/multiple_unsafe_ops_per_block.rs:340:17
+   |
+LL |         assert!(foo() == 0, "{}", 1 + 2);
+   |                 ^^^^^
+
+error: this `unsafe` block contains 2 unsafe operations, expected only one
+  --> tests/ui/multiple_unsafe_ops_per_block.rs:343:5
+   |
+LL | /     unsafe {
+LL | |
+LL | |         assert!(foo() == 0, "{}", foo());
+LL | |     }
+   | |_____^
+   |
+note: unsafe function call occurs here
+  --> tests/ui/multiple_unsafe_ops_per_block.rs:345:17
+   |
+LL |         assert!(foo() == 0, "{}", foo());
+   |                 ^^^^^
+note: unsafe function call occurs here
+  --> tests/ui/multiple_unsafe_ops_per_block.rs:345:35
+   |
+LL |         assert!(foo() == 0, "{}", foo());
+   |                                   ^^^^^
+
+error: aborting due to 19 previous errors