current implement as merged from PR#198 iterates over the blocks independantly for writeRegion . In the case where the N5Writer implementation supports sharding, this will be inefficient. That said, it's likely that N5Writer implementation that support sharding will have to override these methods anyway, so this is not a pressing issue. It's also not trivial to do now with a single writeBlocks call since the region being written could be larger than could fit in memory.
Not a current priority, but here for tracking