diff --git a/.github/scripts/upstream_install.py b/.github/scripts/upstream_install.py
index cb8e7a28c..972344447 100644
--- a/.github/scripts/upstream_install.py
+++ b/.github/scripts/upstream_install.py
@@ -15,7 +15,6 @@ def install_deps() -> None:
     )
     upstream_deps = (
         "git+https://github.com/dask/dask.git#egg=dask[array,dataframe]",
-        "git+https://github.com/dask/distributed.git#egg=distributed",
         "git+https://github.com/pandas-dev/pandas#egg=pandas",
         "git+https://github.com/pangeo-data/rechunker.git#egg=rechunker",
         "git+https://github.com/pydata/xarray.git#egg=xarray",
diff --git a/pyproject.toml b/pyproject.toml
index eb3a10384..7ef0d03c4 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -25,11 +25,9 @@ dependencies = [
   "numpy < 2.2",
   "xarray < 2025.03.1",
   "dask[array,dataframe] >= 2022.01.0, <= 2024.8.0",
-  "distributed >= 2022.01.0, <= 2024.8.0",
   "scipy < 1.16",
   "zarr >= 2.10.0, != 2.11.0, != 2.11.1, != 2.11.2, < 3",
   "numba",
-  "typing-extensions",
   "fsspec != 2021.6.*",
   "scikit-learn",
   "pandas",
@@ -98,7 +96,6 @@ known_third_party = [
   "sgkit_plink",
   "sklearn",
   "sphinx",
-  "typing_extensions",
   "xarray",
   "yaml",
   "zarr",
diff --git a/requirements-numpy1.txt b/requirements-numpy1.txt
index 1b093dc6d..b4da65449 100644
--- a/requirements-numpy1.txt
+++ b/requirements-numpy1.txt
@@ -1,9 +1,7 @@
 numpy < 2
 xarray < 2025.03.1
 dask[array,dataframe] >= 2023.01.0, <= 2024.8.0
-distributed >= 2023.01.0, <= 2024.8.0
 scipy < 1.16
-typing-extensions
 numba
 zarr >= 2.10.0, != 2.11.0, != 2.11.1, != 2.11.2, < 3
 fsspec != 2021.6.*
diff --git a/requirements.txt b/requirements.txt
index 6e87fc554..8b130d40d 100644
--- a/requirements.txt
+++ b/requirements.txt
@@ -1,9 +1,7 @@
 numpy < 2.2
 xarray < 2025.03.1
 dask[array,dataframe] >= 2023.01.0, <= 2024.8.0
-distributed >= 2023.01.0, <= 2024.8.0
 scipy < 1.16
-typing-extensions
 numba
 zarr >= 2.10.0, != 2.11.0, != 2.11.1, != 2.11.2, < 3
 fsspec != 2021.6.*
diff --git a/sgkit/distance/api.py b/sgkit/distance/api.py
index 4593984ea..fb0518584 100644
--- a/sgkit/distance/api.py
+++ b/sgkit/distance/api.py
@@ -1,8 +1,8 @@
 import typing
+from typing import Literal
 
 import dask.array as da
 import numpy as np
-from typing_extensions import Literal
 
 from sgkit.typing import ArrayLike
 
diff --git a/sgkit/stats/aggregation.py b/sgkit/stats/aggregation.py
index 9f3862985..e11eb6e7e 100644
--- a/sgkit/stats/aggregation.py
+++ b/sgkit/stats/aggregation.py
@@ -1,8 +1,7 @@
-from typing import Hashable
+from typing import Hashable, Literal
 
 import numpy as np
 import xarray as xr
-from typing_extensions import Literal
 from xarray import Dataset
 
 import sgkit.distarray as da
diff --git a/sgkit/stats/genedrop.py b/sgkit/stats/genedrop.py
index 1d928904b..1d0e48f85 100644
--- a/sgkit/stats/genedrop.py
+++ b/sgkit/stats/genedrop.py
@@ -1,9 +1,8 @@
-from typing import Hashable, Optional
+from typing import Hashable, Literal, Optional
 
 import dask.array as da
 import numpy as np
 import xarray as xr
-from typing_extensions import Literal
 from xarray import Dataset
 
 from sgkit import variables
diff --git a/sgkit/stats/grm.py b/sgkit/stats/grm.py
index c8b5a380a..1eab4626a 100644
--- a/sgkit/stats/grm.py
+++ b/sgkit/stats/grm.py
@@ -1,8 +1,7 @@
-from typing import Hashable, Optional, Tuple
+from typing import Hashable, Literal, Optional, Tuple
 
 import dask.array as da
 import numpy as np
-from typing_extensions import Literal
 from xarray import Dataset
 
 from sgkit import variables
diff --git a/sgkit/stats/ibs.py b/sgkit/stats/ibs.py
index 964615bb8..3d8bc0429 100644
--- a/sgkit/stats/ibs.py
+++ b/sgkit/stats/ibs.py
@@ -1,7 +1,6 @@
-from typing import Hashable
+from typing import Hashable, Literal
 
 import dask.array as da
-from typing_extensions import Literal
 from xarray import Dataset
 
 from sgkit import variables
diff --git a/sgkit/stats/pca.py b/sgkit/stats/pca.py
index 653f3100b..96be389a8 100644
--- a/sgkit/stats/pca.py
+++ b/sgkit/stats/pca.py
@@ -1,10 +1,9 @@
-from typing import Any, Optional, Union
+from typing import Any, Literal, Optional, Union
 
 import numpy as np
 import xarray as xr
 from sklearn.base import BaseEstimator
 from sklearn.pipeline import Pipeline
-from typing_extensions import Literal
 from xarray import DataArray, Dataset
 
 import sgkit.distarray as da
diff --git a/sgkit/stats/pedigree.py b/sgkit/stats/pedigree.py
index a040fc6de..bff889407 100644
--- a/sgkit/stats/pedigree.py
+++ b/sgkit/stats/pedigree.py
@@ -1,10 +1,9 @@
 import warnings
-from typing import Hashable, Tuple
+from typing import Hashable, Literal, Optional, Tuple
 
 import dask.array as da
 import numpy as np
 import xarray as xr
-from typing_extensions import Literal, Optional
 from xarray import Dataset
 
 from sgkit import variables