Skip to content

Commit 388dae8

Browse files
author
NightlordTW
committed
Revise vignette title
1 parent 5899b7e commit 388dae8

File tree

1 file changed

+4
-2
lines changed

1 file changed

+4
-2
lines changed

vignettes/sampleSize_parallel_2A3E.Rmd

Lines changed: 4 additions & 2 deletions
Original file line numberDiff line numberDiff line change
@@ -246,8 +246,10 @@ When $k>1$, Bonferroni and Sidak correction methods become increasingly conserva
246246
))
247247
```
248248

249-
## Hierarchical Testing of Primary Endpoints {#hierarchical-testing}
250-
Consider that our primary objective is to demonstrate equivalence for the AUCinf endpoint. If this null hypothesis is rejected, we proceed to test AUClast and Cmax. This hierarchical testing approach allows for a more efficient use of resources by focusing on the most critical endpoints first.
249+
## Hierarchical Testing of Endpoints {#hierarchical-testing}
250+
In this trial, the primary objective is to demonstrate equivalence for the AUCinf endpoint. If the null hypothesis for AUCinf is rejected, testing proceeds to AUClast and Cmax.
251+
252+
This hierarchical testing approach prioritizes the most critical endpoint first, ensuring a more efficient use of resources by limiting further testing to cases where the primary equivalence condition is met.
251253

252254
In the example below, sequential adjustment is implemented by setting the argument `adjust = "seq"`. Each endpoint's type is specified using the `type_y` argument. For instance, we define "AUCinf" as a primary endpoint, while "AUClast" and "Cmax" are designated as secondary endpoints. The argument `k` is configured to require:
253255

0 commit comments

Comments
 (0)