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| 1 | +# Scientific Method Core Principles |
| 2 | + |
| 3 | +## Fundamental Principles |
| 4 | + |
| 5 | +### 1. Empiricism |
| 6 | + |
| 7 | +- Knowledge derives from observable, measurable evidence |
| 8 | +- Claims must be testable through observation or experiment |
| 9 | +- Subjective experience alone is insufficient for scientific conclusions |
| 10 | + |
| 11 | +### 2. Falsifiability (Popper's Criterion) |
| 12 | + |
| 13 | +- A hypothesis must be capable of being proven false |
| 14 | +- Unfalsifiable claims are not scientific (e.g., "invisible, undetectable forces") |
| 15 | +- Good hypotheses make specific, testable predictions |
| 16 | + |
| 17 | +### 3. Reproducibility |
| 18 | + |
| 19 | +- Results must be replicable by independent researchers |
| 20 | +- Methods must be described with sufficient detail for replication |
| 21 | +- Single studies are rarely definitive; replication strengthens confidence |
| 22 | + |
| 23 | +### 4. Parsimony (Occam's Razor) |
| 24 | + |
| 25 | +- Prefer simpler explanations over complex ones when both fit the data |
| 26 | +- Don't multiply entities unnecessarily |
| 27 | +- Extraordinary claims require extraordinary evidence |
| 28 | + |
| 29 | +### 5. Systematic Observation |
| 30 | + |
| 31 | +- Use standardized, rigorous methods |
| 32 | +- Control for confounding variables |
| 33 | +- Minimize observer bias through blinding and protocols |
| 34 | + |
| 35 | +## The Scientific Process |
| 36 | + |
| 37 | +### 1. Question Formation |
| 38 | + |
| 39 | +- Identify a specific, answerable question |
| 40 | +- Ensure the question is within the scope of scientific inquiry |
| 41 | +- Consider whether current methods can address the question |
| 42 | + |
| 43 | +### 2. Literature Review |
| 44 | + |
| 45 | +- Survey existing knowledge |
| 46 | +- Identify gaps and contradictions |
| 47 | +- Build on previous work rather than reinventing |
| 48 | + |
| 49 | +### 3. Hypothesis Development |
| 50 | + |
| 51 | +- State a clear, testable prediction |
| 52 | +- Define variables operationally |
| 53 | +- Specify the expected relationship between variables |
| 54 | + |
| 55 | +### 4. Experimental Design |
| 56 | + |
| 57 | +- Choose appropriate methodology |
| 58 | +- Identify independent and dependent variables |
| 59 | +- Control confounding variables |
| 60 | +- Select appropriate sample size and population |
| 61 | +- Plan statistical analyses in advance |
| 62 | + |
| 63 | +### 5. Data Collection |
| 64 | + |
| 65 | +- Follow protocols consistently |
| 66 | +- Record all observations, including unexpected results |
| 67 | +- Maintain detailed lab notebooks or data logs |
| 68 | +- Use validated measurement instruments |
| 69 | + |
| 70 | +### 6. Analysis |
| 71 | + |
| 72 | +- Apply appropriate statistical methods |
| 73 | +- Test assumptions of statistical tests |
| 74 | +- Consider effect size, not just significance |
| 75 | +- Look for alternative explanations |
| 76 | + |
| 77 | +### 7. Interpretation |
| 78 | + |
| 79 | +- Distinguish between correlation and causation |
| 80 | +- Acknowledge limitations |
| 81 | +- Consider alternative interpretations |
| 82 | +- Avoid overgeneralizing beyond the data |
| 83 | + |
| 84 | +### 8. Communication |
| 85 | + |
| 86 | +- Report methods transparently |
| 87 | +- Include negative results |
| 88 | +- Acknowledge conflicts of interest |
| 89 | +- Make data and code available when possible |
| 90 | + |
| 91 | +## Critical Evaluation Criteria |
| 92 | + |
| 93 | +### When Reviewing Scientific Work, Ask: |
| 94 | + |
| 95 | +**Validity Questions:** |
| 96 | + |
| 97 | +- Does the study measure what it claims to measure? |
| 98 | +- Are the methods appropriate for the research question? |
| 99 | +- Were controls adequate? |
| 100 | +- Could confounding variables explain the results? |
| 101 | + |
| 102 | +**Reliability Questions:** |
| 103 | + |
| 104 | +- Are measurements consistent? |
| 105 | +- Would the study produce similar results if repeated? |
| 106 | +- Are inter-rater reliability and measurement precision reported? |
| 107 | + |
| 108 | +**Generalizability Questions:** |
| 109 | + |
| 110 | +- Is the sample representative of the target population? |
| 111 | +- Are the conditions realistic or artificial? |
| 112 | +- Do the results apply beyond the specific context? |
| 113 | + |
| 114 | +**Statistical Questions:** |
| 115 | + |
| 116 | +- Is the sample size adequate for the analysis? |
| 117 | +- Are the statistical tests appropriate? |
| 118 | +- Are effect sizes reported alongside p-values? |
| 119 | +- Were multiple comparisons corrected? |
| 120 | + |
| 121 | +**Logical Questions:** |
| 122 | + |
| 123 | +- Do the conclusions follow from the data? |
| 124 | +- Are alternative explanations considered? |
| 125 | +- Are causal claims supported by the study design? |
| 126 | +- Are limitations acknowledged? |
| 127 | + |
| 128 | +## Red Flags in Scientific Claims |
| 129 | + |
| 130 | +1. **Cherry-picking data** - Highlighting only supporting evidence |
| 131 | +2. **Moving goalposts** - Changing predictions after seeing results |
| 132 | +3. **Ad hoc hypotheses** - Adding explanations to rescue a failed prediction |
| 133 | +4. **Appeal to authority** - "Expert X says" without evidence |
| 134 | +5. **Anecdotal evidence** - Relying on personal stories over systematic data |
| 135 | +6. **Correlation implies causation** - Confusing association with causality |
| 136 | +7. **Post hoc rationalization** - Explaining results after the fact without prediction |
| 137 | +8. **Ignoring base rates** - Not considering prior probability |
| 138 | +9. **Confirmation bias** - Seeking only evidence that supports beliefs |
| 139 | +10. **Publication bias** - Only positive results get published |
| 140 | + |
| 141 | +## Standards for Causal Inference |
| 142 | + |
| 143 | +### Bradford Hill Criteria (adapted) |
| 144 | + |
| 145 | +1. **Strength** - Strong associations are more likely causal |
| 146 | +2. **Consistency** - Repeated observations by different researchers |
| 147 | +3. **Specificity** - Specific outcomes from specific causes |
| 148 | +4. **Temporality** - Cause precedes effect (essential) |
| 149 | +5. **Biological gradient** - Dose-response relationship |
| 150 | +6. **Plausibility** - Coherent with existing knowledge |
| 151 | +7. **Coherence** - Consistent with other evidence |
| 152 | +8. **Experiment** - Experimental evidence supports causation |
| 153 | +9. **Analogy** - Similar cause-effect relationships exist |
| 154 | + |
| 155 | +### Establishing Causation Requires: |
| 156 | + |
| 157 | +- Temporal precedence (cause before effect) |
| 158 | +- Covariation (cause and effect correlate) |
| 159 | +- Elimination of alternative explanations |
| 160 | +- Ideally: experimental manipulation showing cause produces effect |
| 161 | + |
| 162 | +## Peer Review and Scientific Consensus |
| 163 | + |
| 164 | +### Understanding Peer Review |
| 165 | + |
| 166 | +- Filters obvious errors but isn't perfect |
| 167 | +- Reviewers can miss problems or have biases |
| 168 | +- Published ≠ proven; it means "passed initial scrutiny" |
| 169 | +- Retraction mechanisms exist for flawed papers |
| 170 | + |
| 171 | +### Scientific Consensus |
| 172 | + |
| 173 | +- Emerges from convergence of multiple independent lines of evidence |
| 174 | +- Consensus can change with new evidence |
| 175 | +- Individual studies rarely overturn consensus |
| 176 | +- Consider the weight of evidence, not individual papers |
| 177 | + |
| 178 | +## Open Science Principles |
| 179 | + |
| 180 | +### Transparency Practices |
| 181 | + |
| 182 | +- Preregistration of hypotheses and methods |
| 183 | +- Open data sharing |
| 184 | +- Open-source code |
| 185 | +- Preprints for rapid dissemination |
| 186 | +- Registered reports (peer review before data collection) |
| 187 | + |
| 188 | +### Why Transparency Matters |
| 189 | + |
| 190 | +- Reduces publication bias |
| 191 | +- Enables verification |
| 192 | +- Prevents p-hacking and HARKing (Hypothesizing After Results are Known) |
| 193 | +- Accelerates scientific progress |
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