In my profiling, unless I have something configured incorrectly, I'm finding that WrinkleManager and BoneDriver do tons of work every frame to copy blend shapes around even when LOD0 (the only one with blend shapes) is not rendered because the LODGroup disables them. I think these components can just check with Renderer.isVisible or LODGroup to stop doing work until they are on screen. Potentially other off-screen or visibility checks could help too.