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triageLanding area for issues discovered during development.Landing area for issues discovered during development.
Description
Issue or current state
Reading vcfs into mongo backing data will throw errors if newer version of VEP is used with consequences that are not enumerated in snv_consequence2code:
bravo_api/bravo_api/models/readers.py
Lines 49 to 86 in 7a52032
| snv_consequence2code = { name: i for i, name in enumerate(reversed([ | |
| 'transcript_ablation', | |
| 'splice_acceptor_variant', | |
| 'splice_donor_variant', | |
| 'stop_gained', | |
| 'frameshift_variant', | |
| 'stop_lost', | |
| 'start_lost', | |
| 'transcript_amplification', | |
| 'inframe_insertion', | |
| 'inframe_deletion', | |
| 'missense_variant', | |
| 'protein_altering_variant', | |
| 'splice_region_variant', | |
| 'incomplete_terminal_codon_variant', | |
| 'start_retained_variant', | |
| 'stop_retained_variant', | |
| 'synonymous_variant', | |
| 'coding_sequence_variant', | |
| 'mature_miRNA_variant', | |
| '5_prime_UTR_variant', | |
| '3_prime_UTR_variant', | |
| 'non_coding_transcript_exon_variant', | |
| 'intron_variant', | |
| 'NMD_transcript_variant', | |
| 'non_coding_transcript_variant', | |
| 'upstream_gene_variant', | |
| 'downstream_gene_variant', | |
| 'TFBS_ablation', | |
| 'TFBS_amplification', | |
| 'TF_binding_site_variant', | |
| 'regulatory_region_ablation', | |
| 'regulatory_region_amplification', | |
| 'feature_elongation', | |
| 'regulatory_region_variant', | |
| 'feature_truncation', | |
| 'intergenic_variant' | |
| ]), 1)} |
The error will crop up here:
bravo_api/bravo_api/models/readers.py
Line 103 in 7a52032
| consequences = sorted(effect['Consequence'].split('&'), key = lambda x: snv_consequence2code[x], reverse = True) |
Resolved when
A graceful method of handling consequences is implemented and demonstrated functioning with unit tests.
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triageLanding area for issues discovered during development.Landing area for issues discovered during development.