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Gracefully handle loading consequences not in enumeration #22

@grosscol

Description

@grosscol

Issue or current state

Reading vcfs into mongo backing data will throw errors if newer version of VEP is used with consequences that are not enumerated in snv_consequence2code:

snv_consequence2code = { name: i for i, name in enumerate(reversed([
'transcript_ablation',
'splice_acceptor_variant',
'splice_donor_variant',
'stop_gained',
'frameshift_variant',
'stop_lost',
'start_lost',
'transcript_amplification',
'inframe_insertion',
'inframe_deletion',
'missense_variant',
'protein_altering_variant',
'splice_region_variant',
'incomplete_terminal_codon_variant',
'start_retained_variant',
'stop_retained_variant',
'synonymous_variant',
'coding_sequence_variant',
'mature_miRNA_variant',
'5_prime_UTR_variant',
'3_prime_UTR_variant',
'non_coding_transcript_exon_variant',
'intron_variant',
'NMD_transcript_variant',
'non_coding_transcript_variant',
'upstream_gene_variant',
'downstream_gene_variant',
'TFBS_ablation',
'TFBS_amplification',
'TF_binding_site_variant',
'regulatory_region_ablation',
'regulatory_region_amplification',
'feature_elongation',
'regulatory_region_variant',
'feature_truncation',
'intergenic_variant'
]), 1)}

The error will crop up here:

consequences = sorted(effect['Consequence'].split('&'), key = lambda x: snv_consequence2code[x], reverse = True)

Resolved when

A graceful method of handling consequences is implemented and demonstrated functioning with unit tests.

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