diff --git a/Include/internal/pycore_ceval.h b/Include/internal/pycore_ceval.h
index e0b1f099abd613..db46e188b860e7 100644
--- a/Include/internal/pycore_ceval.h
+++ b/Include/internal/pycore_ceval.h
@@ -16,13 +16,6 @@ extern "C" {
 #include "pycore_stats.h"         // EVAL_CALL_STAT_INC()
 #include "pycore_typedefs.h"      // _PyInterpreterFrame
 
-/* HP PA-RISC has a stack that goes up */
-#ifdef __hppa__
-#  define _Py_STACK_GROWS_DOWN 0
-#else
-#  define _Py_STACK_GROWS_DOWN 1
-#endif
-
 /* Forward declarations */
 struct _ceval_runtime_state;
 
diff --git a/Include/pyport.h b/Include/pyport.h
index 62db8d07701d1d..c2e7beba86b5e5 100644
--- a/Include/pyport.h
+++ b/Include/pyport.h
@@ -682,4 +682,10 @@ extern "C" {
 #endif
 
 
+// Assume the stack grows down if not specified by autoconf
+#ifndef _Py_STACK_GROWS_DOWN
+#  define _Py_STACK_GROWS_DOWN 1
+#endif
+
+
 #endif /* Py_PYPORT_H */
diff --git a/Modules/_testcapimodule.c b/Modules/_testcapimodule.c
index 4e73be20e1b709..e451b656c82ea7 100644
--- a/Modules/_testcapimodule.c
+++ b/Modules/_testcapimodule.c
@@ -3324,6 +3324,10 @@ _testcapi_exec(PyObject *m)
     PyModule_AddObject(m, "INT64_MAX", PyLong_FromInt64(INT64_MAX));
     PyModule_AddObject(m, "UINT64_MAX", PyLong_FromUInt64(UINT64_MAX));
 
+    if (PyModule_AddIntMacro(m, _Py_STACK_GROWS_DOWN)) {
+        return -1;
+    }
+
     if (PyModule_AddIntMacro(m, Py_single_input)) {
         return -1;
     }
diff --git a/configure b/configure
index 211f84399064a0..37a3068725bfba 100755
--- a/configure
+++ b/configure
@@ -965,6 +965,7 @@ LDLIBRARY
 LIBRARY
 BUILDEXEEXT
 NO_AS_NEEDED
+_Py_STACK_GROWS_DOWN
 MULTIARCH_CPPFLAGS
 PLATFORM_TRIPLET
 MULTIARCH
@@ -7211,6 +7212,18 @@ if test x$MULTIARCH != x; then
 fi
 
 
+# Guess C stack direction
+case $host in #(
+  hppa-*) :
+    _Py_STACK_GROWS_DOWN=0 ;; #(
+  *) :
+    _Py_STACK_GROWS_DOWN=1 ;;
+esac
+
+printf "%s\n" "#define _Py_STACK_GROWS_DOWN $_Py_STACK_GROWS_DOWN" >>confdefs.h
+
+
+
 { printf "%s\n" "$as_me:${as_lineno-$LINENO}: checking for PEP 11 support tier" >&5
 printf %s "checking for PEP 11 support tier... " >&6; }
 case $host/$ac_cv_cc_name in #(
diff --git a/configure.ac b/configure.ac
index 35bf153a8987b2..eab6c02a110800 100644
--- a/configure.ac
+++ b/configure.ac
@@ -1202,6 +1202,14 @@ if test x$MULTIARCH != x; then
 fi
 AC_SUBST([MULTIARCH_CPPFLAGS])
 
+# Guess C stack direction
+AS_CASE([$host],
+  [hppa-*], [_Py_STACK_GROWS_DOWN=0],
+  [_Py_STACK_GROWS_DOWN=1])
+AC_DEFINE_UNQUOTED([_Py_STACK_GROWS_DOWN], [$_Py_STACK_GROWS_DOWN],
+  [Define to 1 if the machine stack grows down (default); 0 if it grows up.])
+AC_SUBST([_Py_STACK_GROWS_DOWN])
+
 dnl Support tiers according to https://peps.python.org/pep-0011/
 dnl
 dnl NOTE: Windows support tiers are defined in PC/pyconfig.h.
diff --git a/pyconfig.h.in b/pyconfig.h.in
index 72870411bc086a..3919315466e0f3 100644
--- a/pyconfig.h.in
+++ b/pyconfig.h.in
@@ -2026,6 +2026,9 @@
 /* HACL* library can compile SIMD256 implementations */
 #undef _Py_HACL_CAN_COMPILE_VEC256
 
+/* Define to 1 if the machine stack grows down (default); 0 if it grows up. */
+#undef _Py_STACK_GROWS_DOWN
+
 /* Define if you want to use tail-calling interpreters in CPython. */
 #undef _Py_TAIL_CALL_INTERP