diff --git a/.github/workflows/main.yml b/.github/workflows/main.yml
index f96e7122..02cd9422 100644
--- a/.github/workflows/main.yml
+++ b/.github/workflows/main.yml
@@ -120,6 +120,30 @@ jobs:
       - run: ./Vendor/checkout-dependency
       - run: ./build-exec swift test
 
+  build-musl:
+    runs-on: ubuntu-22.04
+    strategy:
+      matrix:
+        include:
+          - swift: 6.0.1-jammy
+            musl-swift-sdk-download: "https://download.swift.org/swift-6.0.1-release/static-sdk/swift-6.0.1-RELEASE/swift-6.0.1-RELEASE_static-linux-0.0.1.artifactbundle.tar.gz"
+            musl-swift-sdk-checksum: "d4f46ba40e11e697387468e18987ee622908bc350310d8af54eb5e17c2ff5481"
+    steps:
+      - uses: actions/checkout@v4
+      - name: Configure container
+        run: |
+          docker run -dit --name build-container -v $PWD:/workspace -w /workspace swift:${{ matrix.swift }}
+          echo 'docker exec -i build-container "$@"' > ./build-exec
+          chmod +x ./build-exec
+
+      - name: Install Static Linux SDK
+        run: ./build-exec swift sdk install "${{ matrix.musl-swift-sdk-download }}" --checksum "${{ matrix.musl-swift-sdk-checksum }}"
+
+      - name: Build (x86_64-swift-linux-musl)
+        run: ./build-exec swift build --swift-sdk x86_64-swift-linux-musl
+      - name: Build (aarch64-swift-linux-musl)
+        run: ./build-exec swift build --swift-sdk aarch64-swift-linux-musl
+
   build-windows:
     runs-on: windows-latest
     steps:
diff --git a/Sources/SystemExtras/Clock.swift b/Sources/SystemExtras/Clock.swift
index 0d491fc2..64cefc5e 100644
--- a/Sources/SystemExtras/Clock.swift
+++ b/Sources/SystemExtras/Clock.swift
@@ -1,8 +1,11 @@
 #if SYSTEM_PACKAGE_DARWIN
 import Darwin
-#elseif os(Linux) || os(FreeBSD) || os(Android)
+#elseif canImport(Glibc)
 import CSystem
 import Glibc
+#elseif canImport(Musl)
+import CSystem
+import Musl
 #elseif os(Windows)
 import CSystem
 import ucrt
diff --git a/Sources/SystemExtras/Constants.swift b/Sources/SystemExtras/Constants.swift
index 0d7aad86..1a32cc06 100644
--- a/Sources/SystemExtras/Constants.swift
+++ b/Sources/SystemExtras/Constants.swift
@@ -1,8 +1,11 @@
 #if SYSTEM_PACKAGE_DARWIN
 import Darwin
-#elseif os(Linux) || os(FreeBSD) || os(Android)
+#elseif canImport(Glibc)
 import CSystem
 import Glibc
+#elseif canImport(Musl)
+import CSystem
+import Musl
 #elseif os(Windows)
 import CSystem
 import ucrt
diff --git a/Sources/SystemExtras/FileAtOperations.swift b/Sources/SystemExtras/FileAtOperations.swift
index e0690103..dc2ff8a2 100644
--- a/Sources/SystemExtras/FileAtOperations.swift
+++ b/Sources/SystemExtras/FileAtOperations.swift
@@ -1,7 +1,11 @@
 #if SYSTEM_PACKAGE_DARWIN
 import Darwin
-#elseif os(Linux) || os(FreeBSD) || os(Android)
+#elseif canImport(Glibc)
+import CSystem
 import Glibc
+#elseif canImport(Musl)
+import CSystem
+import Musl
 #elseif os(Windows)
 import ucrt
 import WinSDK
diff --git a/Sources/SystemExtras/FileOperations.swift b/Sources/SystemExtras/FileOperations.swift
index dad6a7c2..a3b9dada 100644
--- a/Sources/SystemExtras/FileOperations.swift
+++ b/Sources/SystemExtras/FileOperations.swift
@@ -1,7 +1,11 @@
 #if SYSTEM_PACKAGE_DARWIN
 import Darwin
-#elseif os(Linux) || os(FreeBSD) || os(Android)
+#elseif canImport(Glibc)
+import CSystem
 import Glibc
+#elseif canImport(Musl)
+import CSystem
+import Musl
 #elseif os(Windows)
 import ucrt
 import WinSDK
diff --git a/Sources/SystemExtras/Syscalls.swift b/Sources/SystemExtras/Syscalls.swift
index 913edf5c..ddc37839 100644
--- a/Sources/SystemExtras/Syscalls.swift
+++ b/Sources/SystemExtras/Syscalls.swift
@@ -1,7 +1,11 @@
 #if SYSTEM_PACKAGE_DARWIN
 import Darwin
-#elseif os(Linux) || os(FreeBSD) || os(Android)
+#elseif canImport(Glibc)
+import CSystem
 import Glibc
+#elseif canImport(Musl)
+import CSystem
+import Musl
 #elseif os(Windows)
 import ucrt
 import WinSDK
diff --git a/Sources/SystemExtras/Vendor/Exports.swift b/Sources/SystemExtras/Vendor/Exports.swift
index fcfbb807..1714316e 100644
--- a/Sources/SystemExtras/Vendor/Exports.swift
+++ b/Sources/SystemExtras/Vendor/Exports.swift
@@ -1,7 +1,7 @@
 /*
  This source file is part of the Swift System open source project
 
- Copyright (c) 2020 Apple Inc. and the Swift System project authors
+ Copyright (c) 2020 - 2024 Apple Inc. and the Swift System project authors
  Licensed under Apache License v2.0 with Runtime Library Exception
 
  See https://swift.org/LICENSE.txt for license information
@@ -14,12 +14,20 @@
 
 #if SYSTEM_PACKAGE_DARWIN
 import Darwin
-#elseif os(Linux) || os(FreeBSD) || os(Android)
-import CSystem
-import Glibc
 #elseif os(Windows)
 import CSystem
 import ucrt
+#elseif canImport(Glibc)
+import CSystem
+import Glibc
+#elseif canImport(Musl)
+import CSystem
+import Musl
+#elseif canImport(WASILibc)
+import WASILibc
+#elseif canImport(Android)
+import CSystem
+import Android
 #else
 #error("Unsupported Platform")
 #endif
@@ -47,11 +55,26 @@ internal var system_errno: CInt {
     _ = ucrt._set_errno(newValue)
   }
 }
-#else
+#elseif canImport(Glibc)
 internal var system_errno: CInt {
   get { Glibc.errno }
   set { Glibc.errno = newValue }
 }
+#elseif canImport(Musl)
+internal var system_errno: CInt {
+  get { Musl.errno }
+  set { Musl.errno = newValue }
+}
+#elseif canImport(WASILibc)
+internal var system_errno: CInt {
+  get { WASILibc.errno }
+  set { WASILibc.errno = newValue }
+}
+#elseif canImport(Android)
+internal var system_errno: CInt {
+  get { Android.errno }
+  set { Android.errno = newValue }
+}
 #endif
 
 // MARK: C stdlib decls
@@ -62,7 +85,10 @@ internal func system_strerror(_ __errnum: Int32) -> UnsafeMutablePointer<Int8>!
   strerror(__errnum)
 }
 
-internal func system_strlen(_ s: UnsafePointer<Int8>) -> Int {
+internal func system_strlen(_ s: UnsafePointer<CChar>) -> Int {
+  strlen(s)
+}
+internal func system_strlen(_ s: UnsafeMutablePointer<CChar>) -> Int {
   strlen(s)
 }
 
@@ -80,7 +106,17 @@ internal func system_platform_strlen(_ s: UnsafePointer<CInterop.PlatformChar>)
   #endif
 }
 
-// Interop between String and platform string
+// memset for raw buffers
+// FIXME: Do we really not have something like this in the stdlib already?
+internal func system_memset(
+  _ buffer: UnsafeMutableRawBufferPointer,
+  to byte: UInt8
+) {
+  guard buffer.count > 0 else { return }
+  memset(buffer.baseAddress!, CInt(byte), buffer.count)
+}
+
+// Interop between String and platfrom string
 extension String {
   internal func _withPlatformString<Result>(
     _ body: (UnsafePointer<CInterop.PlatformChar>) throws -> Result
@@ -130,6 +166,24 @@ extension String {
 // TLS
 #if os(Windows)
 internal typealias _PlatformTLSKey = DWORD
+#elseif os(WASI) && (swift(<6.1) || !_runtime(_multithreaded))
+// Mock TLS storage for single-threaded WASI
+internal final class _PlatformTLSKey {
+    fileprivate init() {}
+}
+private final class TLSStorage: @unchecked Sendable {
+    var storage = [ObjectIdentifier: UnsafeMutableRawPointer]()
+}
+private let sharedTLSStorage = TLSStorage()
+
+func pthread_setspecific(_ key: _PlatformTLSKey, _ p: UnsafeMutableRawPointer?) -> Int {
+    sharedTLSStorage.storage[ObjectIdentifier(key)] = p
+    return 0
+}
+
+func pthread_getspecific(_ key: _PlatformTLSKey) -> UnsafeMutableRawPointer? {
+    sharedTLSStorage.storage[ObjectIdentifier(key)]
+}
 #else
 internal typealias _PlatformTLSKey = pthread_key_t
 #endif
@@ -141,6 +195,8 @@ internal func makeTLSKey() -> _PlatformTLSKey {
     fatalError("Unable to create key")
   }
   return raw
+  #elseif os(WASI) && (swift(<6.1) || !_runtime(_multithreaded))
+  return _PlatformTLSKey()
   #else
   var raw = pthread_key_t()
   guard 0 == pthread_key_create(&raw, nil) else {
diff --git a/Sources/WASI/WASI.swift b/Sources/WASI/WASI.swift
index ada0e53e..57297871 100644
--- a/Sources/WASI/WASI.swift
+++ b/Sources/WASI/WASI.swift
@@ -4,8 +4,10 @@ import WasmTypes
 
 #if os(macOS) || os(iOS) || os(watchOS) || os(tvOS) || os(visionOS)
     import Darwin
-#elseif os(Linux) || os(FreeBSD) || os(Android)
+#elseif canImport(Glibc)
     import Glibc
+#elseif canImport(Musl)
+    import Musl
 #elseif os(Windows)
     import ucrt
 #else