diff --git a/requirements.txt b/requirements.txt
index 50db6796..6644f387 100644
--- a/requirements.txt
+++ b/requirements.txt
@@ -2,7 +2,7 @@ anndata==0.7.8
 dask==2021.3.0
 numpy>=1.16.4
 pandas==1.1.5
-patsy==0.5.2
+patsy==0.5.3
 pytest==6.2.5
 scipy>=1.2.1
 sparse==0.9.1