diff --git a/requirements/requirements_synapse.txt b/requirements/requirements_synapse.txt
index a5139a38..e5ebe996 100644
--- a/requirements/requirements_synapse.txt
+++ b/requirements/requirements_synapse.txt
@@ -4,7 +4,7 @@ aiohttp==3.12.13
 aiohttp-socks==0.10.1
 aiosmtplib==3.0.2
 pyOpenSSL==24.2.1
-cryptography==43.0.3
+cryptography==45.0.6
 msgpack==1.1.0
 xxhash==3.5.0
 lmdb==1.7.3