diff --git a/ninja/compatibility/files.py b/ninja/compatibility/files.py
index 9e28db8d7..e6bef0f66 100644
--- a/ninja/compatibility/files.py
+++ b/ninja/compatibility/files.py
@@ -28,13 +28,21 @@ def fix_request_files_middleware(get_response: Any) -> Any:
     populated for POST requests.
     https://code.djangoproject.com/ticket/12635
     """
+
+    def should_fix_request_files(request: HttpRequest) -> bool:
+        return (
+            request.method in FIX_METHODS
+            and request.content_type != "application/json"
+            and (
+                ninja_settings.FIX_REQUEST_FILES_URLS is None
+                or ninja_settings.FIX_REQUEST_FILES_URLS.search(request.path)
+            )
+        )
+
     if iscoroutinefunction(get_response):
 
         async def async_middleware(request: HttpRequest) -> Any:
-            if (
-                request.method in FIX_METHODS
-                and request.content_type != "application/json"
-            ):
+            if should_fix_request_files(request):
                 initial_method = request.method
                 request.method = "POST"
                 request.META["REQUEST_METHOD"] = "POST"
@@ -48,10 +56,7 @@ async def async_middleware(request: HttpRequest) -> Any:
     else:
 
         def sync_middleware(request: HttpRequest) -> Any:
-            if (
-                request.method in FIX_METHODS
-                and request.content_type != "application/json"
-            ):
+            if should_fix_request_files(request):
                 initial_method = request.method
                 request.method = "POST"
                 request.META["REQUEST_METHOD"] = "POST"
diff --git a/ninja/conf.py b/ninja/conf.py
index 1584a5ce0..51a4ba137 100644
--- a/ninja/conf.py
+++ b/ninja/conf.py
@@ -1,3 +1,4 @@
+import re
 from math import inf
 from typing import Dict, Optional, Set
 
@@ -29,6 +30,9 @@ class Settings(BaseModel):
     FIX_REQUEST_FILES_METHODS: Set[str] = Field(
         {"PUT", "PATCH", "DELETE"}, alias="NINJA_FIX_REQUEST_FILES_METHODS"
     )
+    FIX_REQUEST_FILES_URLS: Optional[re.Pattern] = Field(
+        None, alias="NINJA_FIX_REQUEST_FILES_URLS"
+    )
 
 
 settings = Settings.model_validate(django_settings)
diff --git a/tests/test_files.py b/tests/test_files.py
index 5b948057b..d5450e094 100644
--- a/tests/test_files.py
+++ b/tests/test_files.py
@@ -1,10 +1,15 @@
+import importlib
+import re
 from typing import List
 
 import pytest
 from django.core.files.uploadedfile import SimpleUploadedFile
+from django.test import override_settings
+from django.test.client import MULTIPART_CONTENT
 from django.utils.datastructures import MultiValueDict
 
 from ninja import File, NinjaAPI, UploadedFile
+from ninja.compatibility.files import fix_request_files_middleware
 from ninja.errors import ConfigError
 from ninja.testing import TestClient
 
@@ -144,3 +149,23 @@ def test_files_fix_middleware():
         @api.patch("/file1")
         def patch_with_file(request, file: UploadedFile):
             return {"name": file.name}
+
+
+@override_settings(NINJA_FIX_REQUEST_FILES_URLS=re.compile(r"^/file\d+"))
+def test_files_fix_middleware_urls(rf):
+    def get_response(request):
+        assert request.FILES == {}
+
+    from ninja import conf
+    from ninja.compatibility import files
+
+    importlib.reload(conf)
+    importlib.reload(files)
+
+    file = SimpleUploadedFile("test.txt", b"data123")
+    post_data = rf._encode_data({"file": file}, MULTIPART_CONTENT)
+    request = rf.generic(
+        "PATCH", "/not-patched", post_data, content_type=MULTIPART_CONTENT
+    )
+
+    fix_request_files_middleware(get_response)(request)