diff --git a/packages/runtime-core/src/renderer.ts b/packages/runtime-core/src/renderer.ts
index f046e93ad85..23c5da8bd57 100644
--- a/packages/runtime-core/src/renderer.ts
+++ b/packages/runtime-core/src/renderer.ts
@@ -2260,7 +2260,7 @@ function baseCreateRenderer(
     // For fragments, directly remove all contained DOM nodes.
     // (fragment child nodes cannot have transition)
     let next
-    while (cur !== end) {
+    while (cur && cur !== end) {
       next = hostNextSibling(cur)!
       hostRemove(cur)
       cur = next