diff --git a/packages-private/dts-test/reactivity.test-d.ts b/packages-private/dts-test/reactivity.test-d.ts
index f5b9176729c..93b07e5e8f8 100644
--- a/packages-private/dts-test/reactivity.test-d.ts
+++ b/packages-private/dts-test/reactivity.test-d.ts
@@ -130,3 +130,16 @@ describe('should not error when assignment', () => {
   record2 = arr
   expectType<string>(record2[0])
 })
+
+describe('unwraps custom symbols', () => {
+  const customSymbol = Symbol('custom')
+  const obj = reactive({
+    [customSymbol]: ref(1),
+    foo: ref(2),
+    [Symbol.toStringTag]: ref(3),
+  })
+
+  expectType<number>(obj[customSymbol])
+  expectType<number>(obj.foo)
+  expectType<Ref<number, number>>(obj[Symbol.toStringTag])
+})
diff --git a/packages/reactivity/src/baseHandlers.ts b/packages/reactivity/src/baseHandlers.ts
index faec3012f40..853d9a209f6 100644
--- a/packages/reactivity/src/baseHandlers.ts
+++ b/packages/reactivity/src/baseHandlers.ts
@@ -27,6 +27,10 @@ import { warn } from './warning'
 
 const isNonTrackableKeys = /*@__PURE__*/ makeMap(`__proto__,__v_isRef,__isVue`)
 
+export type BuiltinSymbols = Extract<
+  (typeof Symbol)[keyof typeof Symbol],
+  symbol
+>
 const builtInSymbols = new Set(
   /*@__PURE__*/
   Object.getOwnPropertyNames(Symbol)
diff --git a/packages/reactivity/src/ref.ts b/packages/reactivity/src/ref.ts
index 59b713dd862..dca613272e0 100644
--- a/packages/reactivity/src/ref.ts
+++ b/packages/reactivity/src/ref.ts
@@ -19,6 +19,7 @@ import {
 import type { ComputedRef, WritableComputedRef } from './computed'
 import { ReactiveFlags, TrackOpTypes, TriggerOpTypes } from './constants'
 import { warn } from './warning'
+import type { BuiltinSymbols } from './baseHandlers'
 
 declare const RefSymbol: unique symbol
 export declare const RawSymbol: unique symbol
@@ -517,6 +518,8 @@ export type UnwrapRefSimple<T> = T extends
             ? { [K in keyof T]: UnwrapRefSimple<T[K]> }
             : T extends object & { [ShallowReactiveMarker]?: never }
               ? {
-                  [P in keyof T]: P extends symbol ? T[P] : UnwrapRef<T[P]>
+                  [P in keyof T]: P extends BuiltinSymbols
+                    ? T[P]
+                    : UnwrapRef<T[P]>
                 }
               : T