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<section class="posts"><h1 class="page_title All English">Osaka University PRIMe: Research Position Available in the Yachie Laboratory of Creative Destruction Biology</h1><h1 class="page_title All Japanese">大阪大学 PRIMe 創造的破壊生物学分野 谷内江研究室 研究員募集</h1><section class="content All English" id="">
<p>We are looking for one Specially Appointed Researcher (Full-Time) who can join the Yachie laboratory at PRIMe, Osaka University in Japan.</p>
</section>
<section class="content All Japanese" id="">
<p>大阪大学 PRIMe 創造的破壊生物学分野 谷内江研究室では，特任研究員1名を募集しています。</p>
</section>
<h2 class="page_title All English">Application guideline</h2><h2 class="page_title All Japanese">募集要項</h2><h3 class="page_title All English">Institute outline</h3><h3 class="page_title All Japanese">機関の説明</h3><section class="content All English" id="">
<p>Premium Research Institute for Human Metaverse Medicine (PRIMe) has been selected as a research center in the 2022 World Premier International Research Center Initiative (WPI) sponsored by the Ministry of Education, Culture, Sports, Science and Technology (MEXT) in Japan. This research institute aims at creating a new scientific field, Human Metaverse Medicine, in which two academic fields, human organoid-based biomedical science and information mathematical science, are combined to understand and provide solutions for modern diseases related to aging. The Yachie Laboratory of Creative Destruction Biology, combining synthetic biology, CRISPR genome editing, and computational approaches, is leading the field of DNA event recording (https://yachie-lab.org/research.html?lang=EN). Furthermore, through collaboration with the Yachie laboratory at the University of British Columbia and other established international collaborations, the successful candidate will have an opportunity to access a world-leading research network.</p>
</section>
<section class="content All Japanese" id="">
<p>文部科学省の令和4年度世界トップレベル研究拠点プログラム（WPI） に 、大阪大学の「ヒューマン・メタバース疾患研究拠点（PRIMe）」が採択されました。本拠点では、「ヒューマン・オルガノイド生命医科学」と「情報・数理科学」の2分野を世界で初めて本格的に融合した全く新しい科学分野「ヒューマン・メタバース疾患学」を創成し、一人ひとりの体内で生じる疾患発症に至るプロセスを、包括的かつ連続的に理解することを目指しています。私達、創造的破壊生物学分野 谷内江研究室 では、CRISPR/Cas9ゲノム編集システムをベースとしたDNAイベントレコーディング（https://yachie-lab.org/research.html?lang=JA）に関連する新規技術群の開発を行っています。The University of British Columbiaにある谷内江研究室との連携を通じて、国際的な研究ネットワークを育むこともできます。</p>
</section>
<h3 class="page_title All English">Research Theme</h3><h3 class="page_title All Japanese">研究テーマ</h3><section class="content All English" id="">
<p>We are currently looking for researchers to join the following project: <br></p>
<p><strong><span style="color:#4285f4">Automating DNA Design & Synthesis Using Conversational AI (CREST BioDX, Project Lead: Hideto Mori)</span></strong>: As genome editing and synthetic biology advance, the demand for DNA synthesis is rapidly increasing, creating a growing need to automate the DNA design and synthesis process. In this project, we aim to develop an AI tool powered by a large language model that can automatically design appropriate plasmid vectors and genetic circuit sequences through interactive dialogues with researchers, along with an automated DNA synthesis platform. Specifically, you will be involved in one of the following tasks:</p>
<ul>
<li>Developing an AI interface that assists in planning DNA cloning experiments through conversations with users.</li>
<li>Exploring novel functional proteins, including genome editing proteins, and proposing and constructing synthetic genetic circuits using those proteins.</li>
</ul>
</section>
<section class="content All Japanese" id="">
<p>現在、以下の研究に携わっていただける研究員を募集しています。<br></p>
<p><strong><span style="color:#0077ff">対話型AIを用いたDNA配列設計・合成の自動化 (CRESTバイオDX , 代表: 森 秀人)</span></strong>: ゲノム編集や合成生物学分野の発展に伴って、DNA合成の需要は急速に拡大しており、DNA設計・合成プロセスの自動化が求められています。しかし、自動化装置の利用が複雑であること、実験プロトコルの共有の仕組みが整っていないなどの理由によって自動化の試みは十分に浸透していません。本研究では、近年開発が進む大規模言語モデルを利用し、研究者との会話を通じて、適切なプラスミドベクターや遺伝子回路の配列を自動的に設計することのできるAIエージェントおよび、DNA配列合成実験の自動化システムの開発を行います。具体的には以下の業務に従事していただきます。</p>
<ul>
<li>ユーザーとの対話を通じてDNAクローニング実験の計画を補助するAIインターフェースの開発。</li>
<li>ゲノム編集タンパク質をはじめとする新規機能性タンパク質の探索や、それらを利用した遺伝子回路の設計、作成。</li>
</ul>
</section>
<h3 class="page_title All English">Requirements</h3><h3 class="page_title All Japanese">応募資格</h3><section class="content All English" id="">
<p>We are seeking individuals with expertise in either the life sciences or mathematical informatics who are enthusiastic about acquiring knowledge and skills from the alternate field. Additionally, applicants must meet the following requirements: <br></p>
<ul>
<li>A Ph.D in a field related to the molecular biology, bioinformatics, informatics, or similar areas. (Candidates expected to obtain their degree by the 2024 academic year may be considered.)</li>
<li>Proficient in programming skills (Python). </li>
<li>Expertise and experience in developing software tools (optional but encouraged).</li>
<li>Expertise and experience in basic molecular cloning experiments (optional but encouraged).</li>
<li>Proficient communication skill in either the English or Japanese language.</li>
</ul>
</section>
<section class="content All Japanese" id="">
<p>生命科学または情報科学の少なくともどちらか一方について専門的な知見、技術を有し、なおかつ他方の知見、技術を学ぶ意欲のある方の応募を歓迎します。
また、以下の条件を満たしていること。<br></p>
<ul>
<li>生命情報科学、情報科学、分子生物学などの博士の学位を有すること。2024年度中に学位取得見込みの場合は応相談。</li>
<li>Python等のプログラミング言語に精通していること。</li>
<li>ソフトウェアツールの設計・構築経験を有することが望ましい。</li>
<li>基本的なDNAクローニング実験の経験を有することが望ましい。</li>
<li>業務遂行に支障のないレベルの日本語または英語の能力があること。</li>
</ul>
</section>
<h3 class="page_title All English">Starting Date</h3><h3 class="page_title All Japanese">着任時期</h3><section class="content All English" id="">
<p>To be determined in consultation.</p>
</section>
<section class="content All Japanese" id="">
<p>相談の上決定 </p>
</section>
<h3 class="page_title All English">Term of employment</h3><h3 class="page_title All Japanese">雇用期間</h3><section class="content All English" id="">
<p>From the starting date to March 31, 2025 <br>
*Following completion of the term, the contract may be extended subject to continuity of work and performance evaluation (the extension limit is March 31, 2029).</p>
</section>
<section class="content All Japanese" id="">
<p>採用日から2025年3月31日まで。<br>
※ただし、業務の継続状況および勤務評価などの審査を経て、最大で採用日から2029年3月31日まで更新可。</p>
</section>
<h3 class="page_title All English">Work Location</h3><h3 class="page_title All Japanese">勤務場所</h3><section class="content All English" id="">
<p>Suita Campus (2-2 Yamadaoka, Suita-City, Osaka, Japan) </p>
</section>
<section class="content All Japanese" id="">
<p>大阪大学吹田キャンパス （大阪府吹田市山田丘2-2）</p>
</section>
<h3 class="page_title All English">Salary and Insurance</h3><h3 class="page_title All Japanese">待遇について</h3><section class="content All English" id="">
<p>The salary will be decided based on the applicants’ qualifications and experience. <br>
6,228,900 - 7,713,600 JPY per annum. (Monthly payments of one-twelfth of annual salary) <br>
Commuting allowance is available. Bonuses and allowances for housing, dependency, and retirement are included in the above-mentioned annual salary and will not be paid separately. <br>
Medical insurance and employee’s pension insurance of the Federation of National Public Service Personnel Mutual Aid Associations, Employment Insurance and Industrial Accident Compensation Insurance. </p>
</section>
<section class="content All Japanese" id="">
<p><a href="https://www.osaka-u.ac.jp/ja/guide/information/joho/kitei_shugyou.html">「48．国立大学法人大阪大学任期付年俸制教職員（特任等教職員）給与規程 別表第1」</a> に従い、応募者の経歴・研究業績・専門分野等を加味して決定します。 <br>
年俸 6,228,900円 - 7,713,600円（12分の1の額を月額基本給として毎月支給。）<br>
通勤手当支給 （※住居手当、扶養手当、退職手当及び賞与は支給しない。）<br>
国家公務員共済組合、雇用保険、労働者災害補償保険に加入。</p>
</section>
<h3 class="page_title All English">Application Documents</h3><h3 class="page_title All Japanese">申請方法</h3><section class="content All English" id="">
<p>When applying for this position, please email mori.hideto.prime<img src="./img/at.gif" style="vertical-align: middle; height: 1em;" alt="[at]">osaka-u.ac.jp (Cc: ikumi-mak<img src="./img/at.gif" style="vertical-align: middle; height: 1em;" alt="[at]">office.osaka-u.ac.jp) with a subject) with the subject line “PRIMe Yachie group recruitment
for a specially appointed researcher (full-time)” and include the following application documents.<br></p>
<ol>
<li>A Curriculum Vitae (CV) including educational background, work experience, academicand social activities, etc., with a photo attached, (format is free) and contact details of at least two potential referees who can provide opinions for the applicant (including their name, affiliation, position, phone number, and email address).</li>
<li>A short summary of previous research and current interest (maximum of two A4 pages,)
<br>
After the document review, interviews will be conducted either in person or online, and a final decision on hiring will be made based on the interview results.</li>
</ol>
</section>
<section class="content All Japanese" id="">
<p>件名を「PRIMe 先端計測学グループ 特任研究員（常勤）応募」とし、以下の書類と一緒に mori.hideto.prime<img src="./img/at.gif" style="vertical-align: middle; height: 1em;" alt="[at]">osaka-u.ac.jp (Cc: ikumi-mak<img src="./img/at.gif" style="vertical-align: middle; height: 1em;" alt="[at]">office.osaka-u.ac.jp) まで、お送り下さい。<br></p>
<ol>
<li>履歴書（学歴、職歴、学会及び社会における活動など、写真貼付、様式自由）。研究業績リスト（原著論文、解説・総説、著書、特許、国内外の学会発表など）、及び応募者について意見を伺える方（最低 2 名）の連絡先（氏名・所属・職位・電話・メールアドレス）を含むこと。</li>
<li>これまでの研究の概要（A4 用紙 2 枚以内）
<br>
通常、書類審査後に直接又はオンラインでの面接を実施して、採用可否を決定します。</li>
</ol>
</section>
<h3 class="page_title All Japanese">その他</h3><section class="content All Japanese" id="">
<p>40 歳未満の方については、JSTの「若手研究者の自発的な研究活動等に関する実施方針」に則り、
エフォートの一部（最大20%以内）で現在行っているご自身の研究や競争的研究費への応募を行うことが可能です。
より詳細な情報については、<a href="https://prime.osaka-u.ac.jp/wp/wp-content/uploads/2024/10/PRIMe_YachieLab_SpeciallyApointedResearcherfulltime_Japanese.pdf">こちら</a>をご覧ください。</p>
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<p><strong>Yachie Laboratory</strong><br>
Premium Research Institute for Human Metaverse Medicine (PRIMe)<br>
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2-2, Yamadaoka<br>
Suita, Osaka, Japan 565-0871</p>
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