Add page for enzymm tool

Author: RayHackett

assets/images/tools/2026-02-17-enzymm-abstract.png

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+---
+layout: tools
+title: "Enzyme Motif Miner"
+contributors: [rehackett, mlarralde]
+handle: enzymm
+status: complete
+type: software
+projects: [function]
+
+# Optional
+website: "https://enzymm.readthedocs.io/en/latest/"
+publications: "https://www.biorxiv.org/content/10.64898/2026.02.10.705182v1"
+doi: "10.64898/2026.02.10.705182"
+image: assets/images/placeholder.png
+tagline: Geometric matching of catalytic motifs in protein structures.
+tags: [bioinformatics, function, enzymm]
+
+# Data and code
+github: ["https://github.com/RayHackett/enzymm"]
+---
+{% include JB/setup %}
+
+
+## Abstract
+Enzyme Motif Miner, EnzyMM for short, is a computational tool to identify catalytic
+sites in protein structures. It searches protein structures provided by the user
+against a database of templates. EnzyMM ships with a library of catalytic templates
+derived from the Mechanism and Catalytic Site Atlas (M-CSA) but you can also
+generate your own. These templates represent consensus arrangements of catalytic sites
+found in active sites of experimental protein structures.
+By comparing the geometric orientation of amino acids, rather than relying on sequence
+similarity, our approach is very fast while remaining interpretable.
+We can uncover distant relationships between enzymes, suggesting how functions
+may have evolved. Keeping pace with structure prediction, this method is well
+suited for annotating catalytic sites across entire proteomes.
+
+Enzyme Motif Miner is implemented in [Python](https://www.python.org/), supports all versions from [Python 3.7](https://endoflife.date/python) and is provided under an [MIT Licence](https://choosealicense.com/licenses/mit).  
+
+![EnzyMM abstract](assets/images/tools/2026-02-17-enzymm-abstract.png)
+
+For the actual geometric matching EnzyMM relies on [PyJess](https://github.com/althonos/pyjess) - a [Cython](https://cython.org/) wrapper of [Jess](https://github.com/iriziotis/jess).  
+If you just want to try EnzyMM we provide a webserver at https://www.ebi.ac.uk/thornton-srv/m-csa/enzymm .