diff --git a/boards/arm/bl654_usb/CMakeLists.txt b/boards/arm/bl654_usb/CMakeLists.txt
new file mode 100644
index 0000000000000..ed35c14cf6e01
--- /dev/null
+++ b/boards/arm/bl654_usb/CMakeLists.txt
@@ -0,0 +1,7 @@
+# Copyright (c) 2021 Laird Connectivity.
+# SPDX-License-Identifier: Apache-2.0
+
+if (CONFIG_BOARD_BL654_USB AND CONFIG_BOARD_ENABLE_USB_AUTOMATICALLY)
+zephyr_library()
+zephyr_library_sources(bl654_usb_enable_usb.c)
+endif()
diff --git a/boards/arm/bl654_usb/Kconfig b/boards/arm/bl654_usb/Kconfig
index a445fd15f5e8a..51695165ddf18 100644
--- a/boards/arm/bl654_usb/Kconfig
+++ b/boards/arm/bl654_usb/Kconfig
@@ -8,3 +8,19 @@ config BOARD_ENABLE_DCDC
 	select SOC_DCDC_NRF52X
 	default y
 	depends on BOARD_BL654_USB
+
+config BOARD_ENABLE_USB_AUTOMATICALLY
+	bool "Enable USB automatically"
+	default y if USB_UART_CONSOLE
+	depends on BOARD_BL654_USB
+	help
+	  Will automatically enable the USB peripheral upon boot if USB console
+	  mode is selected, which means manually enabling USB from user-code is
+	  not required
+
+config BOARD_ENABLE_USB_AUTOMATICALLY_INIT_PRIORITY
+	int "USB automatic init priority"
+	default 96
+	depends on BOARD_ENABLE_USB_AUTOMATICALLY
+	help
+	  Automatic USB peripheral enablement initialisation priority
diff --git a/boards/arm/bl654_usb/Kconfig.defconfig b/boards/arm/bl654_usb/Kconfig.defconfig
index 56125667cbb3e..99e269f524c3a 100644
--- a/boards/arm/bl654_usb/Kconfig.defconfig
+++ b/boards/arm/bl654_usb/Kconfig.defconfig
@@ -26,7 +26,10 @@ config FLASH_LOAD_OFFSET
 if USB_DEVICE_STACK
 
 config USB_UART_CONSOLE
-	default y
+	default y if !USB_DEVICE_BLUETOOTH
+
+config USB_CDC_ACM
+	default n if USB_DEVICE_BLUETOOTH
 
 config UART_LINE_CTRL
 	default y
diff --git a/boards/arm/bl654_usb/bl654_usb_enable_usb.c b/boards/arm/bl654_usb/bl654_usb_enable_usb.c
new file mode 100644
index 0000000000000..9c6b771196869
--- /dev/null
+++ b/boards/arm/bl654_usb/bl654_usb_enable_usb.c
@@ -0,0 +1,20 @@
+/*
+ * Copyright (c) 2021 Laird Connectivity
+ *
+ * SPDX-License-Identifier: Apache-2.0
+ */
+
+#include <zephyr.h>
+#include <init.h>
+#include <usb/usb_device.h>
+
+static int usb_enable_boot(const struct device *dev)
+{
+	ARG_UNUSED(dev);
+	usb_enable(NULL);
+
+	return 0;
+}
+
+SYS_INIT(usb_enable_boot, POST_KERNEL,
+	 CONFIG_BOARD_ENABLE_USB_AUTOMATICALLY_INIT_PRIORITY);