diff --git a/drivers/adc/adc_sam0.c b/drivers/adc/adc_sam0.c
index 014692d96b493..e664f2e50c0dc 100644
--- a/drivers/adc/adc_sam0.c
+++ b/drivers/adc/adc_sam0.c
@@ -392,7 +392,8 @@ static int start_read(const struct device *dev,
 
 	wait_synchronization(adc);
 
-	if (sequence->channels != 1U) {
+	if ((sequence->channels == 0) ||
+		((sequence->channels & (sequence->channels - 1)) != 0)) {
 		LOG_ERR("Channel scanning is not supported");
 		return -ENOTSUP;
 	}
diff --git a/samples/drivers/adc/boards/arduino_zero.overlay b/samples/drivers/adc/boards/arduino_zero.overlay
new file mode 100644
index 0000000000000..c3b7012755ea0
--- /dev/null
+++ b/samples/drivers/adc/boards/arduino_zero.overlay
@@ -0,0 +1,16 @@
+/*
+ * SPDX-License-Identifier: Apache-2.0
+ *
+ * Copyright (c) 2022 Kim Bøndergaard <kim@fam-boendergaard.dk>
+ */
+
+/ {
+	zephyr,user {
+		/* J106.6 (A5) aka D21G18, pin PB02_AIN10 */
+		io-channels = <&adc 10>;
+	};
+};
+
+&adc {
+	status = "okay";
+};
diff --git a/samples/drivers/adc/src/main.c b/samples/drivers/adc/src/main.c
index 338f892eed84a..76b554c793de8 100644
--- a/samples/drivers/adc/src/main.c
+++ b/samples/drivers/adc/src/main.c
@@ -49,7 +49,11 @@ struct adc_channel_cfg channel_cfg = {
 	.acquisition_time = ADC_ACQUISITION_TIME,
 	/* channel ID will be overwritten below */
 	.channel_id = 0,
-	.differential = 0
+	.differential = 0,
+#ifdef CONFIG_ADC_CONFIGURABLE_INPUTS
+	.input_negative = 0,
+	.input_positive = 0,
+#endif
 };
 
 struct adc_sequence sequence = {
@@ -80,6 +84,9 @@ void main(void)
 		channel_cfg.input_positive = SAADC_CH_PSELP_PSELP_AnalogInput0
 					     + channel_ids[i];
 #endif
+#ifdef CONFIG_ADC_CONFIGURABLE_INPUTS
+		channel_cfg.input_positive = channel_ids[i];
+#endif
 
 		adc_channel_setup(dev_adc, &channel_cfg);