diff --git a/samples/userspace/shared_mem/boards/nucleo_f746zg.overlay b/samples/userspace/shared_mem/boards/nucleo_f746zg.overlay
new file mode 100644
index 0000000000000..50fa5dcc6e1bf
--- /dev/null
+++ b/samples/userspace/shared_mem/boards/nucleo_f746zg.overlay
@@ -0,0 +1,13 @@
+/*
+ * Copyright 2023 STMicroelectronics
+ *
+ * SPDX-License-Identifier: Apache-2.0
+ */
+
+/*
+ * Disable quadspi MPU region for testing
+ * on this stm32f7 target
+ * else one region is missing among 8 MPU regions
+ */
+
+/delete-node/ &quadspi_memory;
diff --git a/tests/kernel/mem_protect/userspace/boards/nucleo_f746zg.overlay b/tests/kernel/mem_protect/userspace/boards/nucleo_f746zg.overlay
new file mode 100644
index 0000000000000..50fa5dcc6e1bf
--- /dev/null
+++ b/tests/kernel/mem_protect/userspace/boards/nucleo_f746zg.overlay
@@ -0,0 +1,13 @@
+/*
+ * Copyright 2023 STMicroelectronics
+ *
+ * SPDX-License-Identifier: Apache-2.0
+ */
+
+/*
+ * Disable quadspi MPU region for testing
+ * on this stm32f7 target
+ * else one region is missing among 8 MPU regions
+ */
+
+/delete-node/ &quadspi_memory;