diff --git a/boards/st/sensortile_box_pro/doc/index.rst b/boards/st/sensortile_box_pro/doc/index.rst
index 0d824aa9543e1..50540f91f7734 100644
--- a/boards/st/sensortile_box_pro/doc/index.rst
+++ b/boards/st/sensortile_box_pro/doc/index.rst
@@ -163,8 +163,6 @@ Motion and environmental sensors
     (`lps22df datasheet`_)
   - **LIS2DU12** 3-axis accelerometer
     (`lis2du12 datasheet`_)
-  - **HTS221** Humidity sensor
-    (`hts221 datasheet`_)
   - **STTS22H** Digital temperature sensor
     (`stts22hh datasheet`_)
   - **MP23db01HP** Microphone / audio sensor
@@ -353,9 +351,6 @@ References
 .. _lis2du12 datasheet:
    https://www.st.com/en/mems-and-sensors/lis2du12.html
 
-.. _hts221 datasheet:
-   https://www.st.com/en/mems-and-sensors/hts221.html
-
 .. _stts22hh datasheet:
    https://www.st.com/en/mems-and-sensors/stts22h.html
 
diff --git a/boards/st/sensortile_box_pro/sensortile_box_pro.dts b/boards/st/sensortile_box_pro/sensortile_box_pro.dts
index 1d942fe83aeef..7014fd86a7e53 100644
--- a/boards/st/sensortile_box_pro/sensortile_box_pro.dts
+++ b/boards/st/sensortile_box_pro/sensortile_box_pro.dts
@@ -228,13 +228,6 @@ stm32_lp_tick_source: &lptim1 {
 	status = "okay";
 	clock-frequency = <I2C_BITRATE_FAST>;
 
-	hts221@5f {
-		compatible = "st,hts221";
-		reg = <0x5f>;
-		drdy-gpios = <&gpioe 11 GPIO_ACTIVE_HIGH>;
-		status = "okay";
-	};
-
 	lps22df@5d {
 		compatible = "st,lps22df";
 		reg = <0x5d>;
diff --git a/samples/boards/sensortile_box_pro/sensors-on-board/README.rst b/samples/boards/sensortile_box_pro/sensors-on-board/README.rst
index ce0034e2d86d2..556f209923b12 100644
--- a/samples/boards/sensortile_box_pro/sensors-on-board/README.rst
+++ b/samples/boards/sensortile_box_pro/sensors-on-board/README.rst
@@ -12,7 +12,6 @@ This sample enables all sensors of SensorTile.box Pro board, and then
 periodically reads and displays data on the console from the following
 sensors:
 
-- HTS221: ambient temperature and relative humidity
 - LPS22DF: ambient temperature and atmospheric pressure
 - LSM6DSV16X: 6-Axis acceleration and angular velocity
 - LIS2DU12: 3-Axis acceleration
@@ -62,8 +61,6 @@ The sample code outputs sensors data on the SensorTile.box Pro console.
 
     SensorTile.box Pro dashboard
 
-    HTS221: Temperature: 26.4 C
-    HTS221: Relative Humidity: 60.5%
     LPS22DF: Temperature: 28.4 C
     LPS22DF: Pressure:99.694 kpa
     LSM6DSV16X: Accel (m.s-2): x: -0.158, y: 0.158, z: 9.811
diff --git a/samples/boards/sensortile_box_pro/sensors-on-board/prj.conf b/samples/boards/sensortile_box_pro/sensors-on-board/prj.conf
index 97e6a2d17f220..41a681705d48e 100644
--- a/samples/boards/sensortile_box_pro/sensors-on-board/prj.conf
+++ b/samples/boards/sensortile_box_pro/sensors-on-board/prj.conf
@@ -7,7 +7,6 @@ CONFIG_GPIO=y
 # config sensors
 CONFIG_SENSOR=y
 CONFIG_SENSOR_LOG_LEVEL_DBG=y
-CONFIG_HTS221_TRIGGER_NONE=y
 CONFIG_LPS2XDF_TRIGGER_OWN_THREAD=y
 CONFIG_LSM6DSV16X_TRIGGER_OWN_THREAD=y
 CONFIG_LIS2MDL_TRIGGER_OWN_THREAD=y
diff --git a/samples/boards/sensortile_box_pro/sensors-on-board/src/main.c b/samples/boards/sensortile_box_pro/sensors-on-board/src/main.c
index 6ba2e3e226bb1..42141697aeea0 100644
--- a/samples/boards/sensortile_box_pro/sensors-on-board/src/main.c
+++ b/samples/boards/sensortile_box_pro/sensors-on-board/src/main.c
@@ -299,17 +299,12 @@ int main(void)
 
 	printk("SensorTile.box Pro sensor test\n");
 
-	const struct device *const hts221 = DEVICE_DT_GET_ONE(st_hts221);
 	const struct device *const lps22df = DEVICE_DT_GET_ONE(st_lps22df);
 	const struct device *const lsm6dsv16x = DEVICE_DT_GET_ONE(st_lsm6dsv16x);
 	const struct device *const lis2mdl = DEVICE_DT_GET_ONE(st_lis2mdl);
 	const struct device *const lis2du12 = DEVICE_DT_GET_ONE(st_lis2du12);
 	const struct device *const stts22h = DEVICE_DT_GET_ONE(st_stts22h);
 
-	if (!device_is_ready(hts221)) {
-		printk("%s: device not ready.\n", hts221->name);
-		return 0;
-	}
 	if (!device_is_ready(lps22df)) {
 		printk("%s: device not ready.\n", lps22df->name);
 		return 0;
@@ -338,7 +333,6 @@ int main(void)
 	lsm6dsv16x_config(lsm6dsv16x);
 
 	while (1) {
-		struct sensor_value hts221_hum, hts221_temp;
 		struct sensor_value lps22df_press, lps22df_temp;
 		struct sensor_value lsm6dsv16x_accel[3], lsm6dsv16x_gyro[3];
 		struct sensor_value lis2mdl_magn[3];
@@ -346,12 +340,6 @@ int main(void)
 		struct sensor_value lis2du12_accel[3];
 		struct sensor_value stts22h_temp;
 
-		/* handle HTS221 sensor */
-		if (sensor_sample_fetch(hts221) < 0) {
-			printf("HTS221 Sensor sample update error\n");
-			return 0;
-		}
-
 #ifndef CONFIG_LSM6DSV16X_TRIGGER
 		if (sensor_sample_fetch(lsm6dsv16x) < 0) {
 			printf("LSM6DSV16X Sensor sample update error\n");
@@ -387,8 +375,6 @@ int main(void)
 		}
 #endif
 
-		sensor_channel_get(hts221, SENSOR_CHAN_HUMIDITY, &hts221_hum);
-		sensor_channel_get(hts221, SENSOR_CHAN_AMBIENT_TEMP, &hts221_temp);
 		sensor_channel_get(lps22df, SENSOR_CHAN_AMBIENT_TEMP, &lps22df_temp);
 		sensor_channel_get(lps22df, SENSOR_CHAN_PRESS, &lps22df_press);
 		sensor_channel_get(lsm6dsv16x, SENSOR_CHAN_ACCEL_XYZ, lsm6dsv16x_accel);
@@ -405,14 +391,6 @@ int main(void)
 
 		printf("SensorTile.box dashboard\n\n");
 
-		/* HTS221 temperature */
-		printf("HTS221: Temperature: %.1f C\n",
-		       sensor_value_to_double(&hts221_temp));
-
-		/* HTS221 humidity */
-		printf("HTS221: Relative Humidity: %.1f%%\n",
-		       sensor_value_to_double(&hts221_hum));
-
 		/* temperature */
 		printf("LPS22DF: Temperature: %.1f C\n",
 		       sensor_value_to_double(&lps22df_temp));