diff --git a/boards/st/stm32h573i_dk/board.cmake b/boards/st/stm32h573i_dk/board.cmake
index 1ce1627e7eb74..a98d8bd66650b 100644
--- a/boards/st/stm32h573i_dk/board.cmake
+++ b/boards/st/stm32h573i_dk/board.cmake
@@ -1,11 +1,9 @@
 # SPDX-License-Identifier: Apache-2.0
 
 # keep first
-if(CONFIG_STM32_MEMMAP)
-board_runner_args(stm32cubeprogrammer "--port=swd" "--reset-mode=hw")
-board_runner_args(stm32cubeprogrammer "--extload=MX25LM51245G_STM32H573I-DK-RevB-SFIx.stldr")
-else()
 board_runner_args(stm32cubeprogrammer "--port=swd" "--reset-mode=hw")
+if(CONFIG_STM32_MEMMAP OR (CONFIG_XIP AND CONFIG_BOOTLOADER_MCUBOOT))
+  board_runner_args(stm32cubeprogrammer "--extload=MX25LM51245G_STM32H573I-DK-RevB-SFIx.stldr")
 endif()
 
 board_runner_args(pyocd "--target=stm32h573iikx")
diff --git a/boards/st/stm32h573i_dk/stm32h573i_dk.dts b/boards/st/stm32h573i_dk/stm32h573i_dk.dts
index f839c1eb1967e..c431357be226a 100644
--- a/boards/st/stm32h573i_dk/stm32h573i_dk.dts
+++ b/boards/st/stm32h573i_dk/stm32h573i_dk.dts
@@ -307,21 +307,6 @@
 			reg = <0x00000000 DT_SIZE_K(64)>;
 		};
 
-		slot0_partition: partition@10000 {
-			label = "image-0";
-			reg = <0x00010000 DT_SIZE_K(416)>;
-		};
-
-		slot1_partition: partition@78000 {
-			label = "image-1";
-			reg = <0x00078000 DT_SIZE_K(416)>;
-		};
-
-		scratch_partition: partition@e0000 {
-			label = "image-scratch";
-			reg = <0x000e0000 DT_SIZE_K(64)>;
-		};
-
 		/* Set 64KB of storage at the end of Bank1 */
 		storage_partition: partition@f0000 {
 			label = "storage";
@@ -406,9 +391,19 @@
 			#address-cells = <1>;
 			#size-cells = <1>;
 
-			partition@0 {
-				label = "nor";
-				reg = <0x00000000 DT_SIZE_M(64)>;
+			slot0_partition: partition@0 {
+				label = "image-0";
+				reg = <0x00000000 DT_SIZE_M(16)>;
+			};
+
+			slot1_partition: partition@1000000 {
+				label = "image-1";
+				reg = <0x01000000 DT_SIZE_M(16)>;
+			};
+
+			scratch_partition: partition@2000000 {
+				label = "image-scratch";
+				reg = <0x02000000 DT_SIZE_M(24)>;
 			};
 		};
 	};
diff --git a/boards/st/stm32h573i_dk/stm32h573i_dk.yaml b/boards/st/stm32h573i_dk/stm32h573i_dk.yaml
index a743fbca02f6d..c52fa0c3f6d06 100644
--- a/boards/st/stm32h573i_dk/stm32h573i_dk.yaml
+++ b/boards/st/stm32h573i_dk/stm32h573i_dk.yaml
@@ -24,7 +24,6 @@ supported:
   - spi
   - octospi
   - can
-  - usb_device
   - i2c
   - rtc
   - usbd
diff --git a/drivers/clock_control/clock_stm32_ll_h5.c b/drivers/clock_control/clock_stm32_ll_h5.c
index 7ea568149703e..feb1e9812e94f 100644
--- a/drivers/clock_control/clock_stm32_ll_h5.c
+++ b/drivers/clock_control/clock_stm32_ll_h5.c
@@ -349,10 +349,36 @@ static int stm32_clock_control_get_subsys_rate(const struct device *dev,
 	return 0;
 }
 
+static enum clock_control_status stm32_clock_control_get_status(const struct device *dev,
+								clock_control_subsys_t sub_system)
+{
+	struct stm32_pclken *pclken = (struct stm32_pclken *)sub_system;
+
+	ARG_UNUSED(dev);
+
+	if (IN_RANGE(pclken->bus, STM32_PERIPH_BUS_MIN, STM32_PERIPH_BUS_MAX) == true) {
+		/* Gated clocks */
+		if ((sys_read32(DT_REG_ADDR(DT_NODELABEL(rcc)) + pclken->bus) & pclken->enr)
+		    == pclken->enr) {
+			return CLOCK_CONTROL_STATUS_ON;
+		} else {
+			return CLOCK_CONTROL_STATUS_OFF;
+		}
+	} else {
+		/* Domain clock sources */
+		if (enabled_clock(pclken->bus) == 0) {
+			return CLOCK_CONTROL_STATUS_ON;
+		} else {
+			return CLOCK_CONTROL_STATUS_OFF;
+		}
+	}
+}
+
 static DEVICE_API(clock_control, stm32_clock_control_api) = {
 	.on = stm32_clock_control_on,
 	.off = stm32_clock_control_off,
 	.get_rate = stm32_clock_control_get_subsys_rate,
+	.get_status = stm32_clock_control_get_status,
 	.configure = stm32_clock_control_configure,
 };
 
@@ -435,7 +461,19 @@ static int set_up_plls(void)
 #endif
 
 #if defined(STM32_PLL_ENABLED)
+
+#if defined(CONFIG_STM32_APP_IN_EXT_FLASH)
 	/*
+	 * Don't disable PLL1 during application initialization
+	 * that runs on the external octospi flash (in memmap mode)
+	 * when (Q/O)SPI uses PLL1 as its clock source.
+	 */
+	if (LL_RCC_GetOCTOSPIClockSource(LL_RCC_OCTOSPI_CLKSOURCE) == LL_RCC_OSPI_CLKSOURCE_PLL1Q) {
+		goto setup_pll2;
+	}
+#endif /* CONFIG_STM32_APP_IN_EXT_FLASH */
+	/*
+	 * Case of chain-loaded applications:
 	 * Switch to HSI and disable the PLL before configuration.
 	 * (Switching to HSI makes sure we have a SYSCLK source in
 	 * case we're currently running from the PLL we're about to
@@ -501,12 +539,30 @@ static int set_up_plls(void)
 	LL_RCC_PLL1_Enable();
 	while (LL_RCC_PLL1_IsReady() != 1U) {
 	}
+
+	goto setup_pll2;
 #else
 	/* Init PLL source to None */
 	LL_RCC_PLL1_SetSource(LL_RCC_PLL1SOURCE_NONE);
+
+	goto setup_pll2;
 #endif /* STM32_PLL_ENABLED */
 
+setup_pll2:
 #if defined(STM32_PLL2_ENABLED)
+
+#if defined(CONFIG_STM32_APP_IN_EXT_FLASH)
+	/*
+	 * Don't disable PLL2 during application initialization
+	 * that runs on the external octospi flash (in memmap mode)
+	 * when (Q/O)SPI uses PLL2 as its clock source.
+	 */
+	if (LL_RCC_GetOCTOSPIClockSource(LL_RCC_OCTOSPI_CLKSOURCE) == LL_RCC_OSPI_CLKSOURCE_PLL2R) {
+		goto setup_pll3;
+	}
+#endif /* CONFIG_STM32_APP_IN_EXT_FLASH */
+	LL_RCC_PLL2_Disable();
+
 	/* Configure PLL2 source */
 	if (IS_ENABLED(STM32_PLL2_SRC_HSE)) {
 		LL_RCC_PLL2_SetSource(LL_RCC_PLL2SOURCE_HSE);
@@ -554,11 +610,16 @@ static int set_up_plls(void)
 	LL_RCC_PLL2_Enable();
 	while (LL_RCC_PLL2_IsReady() != 1U) {
 	}
+
+	goto setup_pll3;
 #else
 	/* Init PLL2 source to None */
 	LL_RCC_PLL2_SetSource(LL_RCC_PLL2SOURCE_NONE);
+
+	goto setup_pll3;
 #endif /* STM32_PLL2_ENABLED */
 
+setup_pll3:
 #if defined(RCC_CR_PLL3ON)
 #if defined(STM32_PLL3_ENABLED)
 	/* Configure PLL3 source */
diff --git a/drivers/flash/flash_stm32_xspi.c b/drivers/flash/flash_stm32_xspi.c
index 78068413600e6..6ff3262598502 100644
--- a/drivers/flash/flash_stm32_xspi.c
+++ b/drivers/flash/flash_stm32_xspi.c
@@ -966,16 +966,6 @@ static int stm32_xspi_set_memorymap(const struct device *dev)
 	return 0;
 }
 
-/* Function to return true if the octoflash is in MemoryMapped else false */
-static bool stm32_xspi_is_memorymap(const struct device *dev)
-{
-	struct flash_stm32_xspi_data *dev_data = dev->data;
-
-	return ((READ_BIT(dev_data->hxspi.Instance->CR,
-			  XSPI_CR_FMODE) == XSPI_CR_FMODE) ?
-			  true : false);
-}
-
 static int stm32_xspi_abort(const struct device *dev)
 {
 	struct flash_stm32_xspi_data *dev_data = dev->data;
@@ -989,6 +979,17 @@ static int stm32_xspi_abort(const struct device *dev)
 }
 #endif /* CONFIG_STM32_MEMMAP */
 
+
+#if defined(CONFIG_STM32_MEMMAP) || defined(CONFIG_STM32_APP_IN_EXT_FLASH)
+/* Function to return true if the octoflash is in MemoryMapped else false */
+static bool stm32_xspi_is_memorymap(const struct device *dev)
+{
+	struct flash_stm32_xspi_data *dev_data = dev->data;
+
+	return READ_BIT(dev_data->hxspi.Instance->CR, XSPI_CR_FMODE) == XSPI_CR_FMODE;
+}
+#endif
+
 /*
  * Function to erase the flash : chip or sector with possible OCTO/SPI and STR/DTR
  * to erase the complete chip (using dedicated command) :
@@ -2047,7 +2048,7 @@ static int flash_stm32_xspi_init(const struct device *dev)
 		return -ENODEV;
 	}
 
-#ifdef CONFIG_STM32_MEMMAP
+#ifdef CONFIG_STM32_APP_IN_EXT_FLASH
 	/* If MemoryMapped then configure skip init
 	 * Check clock status first as reading CR register without bus clock doesn't work on N6
 	 * If clock is off, then MemoryMapped is off too and we do init
@@ -2056,13 +2057,13 @@ static int flash_stm32_xspi_init(const struct device *dev)
 				     (clock_control_subsys_t) &dev_cfg->pclken)
 				     == CLOCK_CONTROL_STATUS_ON) {
 		if (stm32_xspi_is_memorymap(dev)) {
-			LOG_ERR("NOR init'd in MemMapped mode");
+			LOG_DBG("NOR init'd in MemMapped mode");
 			/* Force HAL instance in correct state */
 			dev_data->hxspi.State = HAL_XSPI_STATE_BUSY_MEM_MAPPED;
 			return 0;
 		}
 	}
-#endif /* CONFIG_STM32_MEMMAP */
+#endif /* CONFIG_STM32_APP_IN_EXT_FLASH */
 
 	/* The SPI/DTR is not a valid config of data_mode/data_rate according to the DTS */
 	if ((dev_cfg->data_mode != XSPI_OCTO_MODE)
diff --git a/samples/subsys/mgmt/hawkbit/boards/stm32h573i_dk.overlay b/samples/subsys/mgmt/hawkbit/boards/stm32h573i_dk.overlay
new file mode 100644
index 0000000000000..2e4030e522419
--- /dev/null
+++ b/samples/subsys/mgmt/hawkbit/boards/stm32h573i_dk.overlay
@@ -0,0 +1,16 @@
+/*
+ * Copyright (c) 2025 STMicroelectronics
+ *
+ * SPDX-License-Identifier: Apache-2.0
+ */
+
+/*
+ * Define the device, controller and partition to be the external memory
+ * for running the application in external NOR from MCUboot
+ */
+/ {
+	chosen {
+		zephyr,flash = &mx25lm51245;
+		zephyr,flash-controller = &mx25lm51245;
+	};
+};
diff --git a/samples/subsys/mgmt/hawkbit/sample.yaml b/samples/subsys/mgmt/hawkbit/sample.yaml
index 14b066625318e..c37258106b10a 100644
--- a/samples/subsys/mgmt/hawkbit/sample.yaml
+++ b/samples/subsys/mgmt/hawkbit/sample.yaml
@@ -17,8 +17,6 @@ tests:
   sample.net.hawkbit.default: {}
   sample.net.hawkbit.sysbuild:
     sysbuild: true
-    extra_args:
-      - platform:stm32h573i_dk/stm32h573xx:mcuboot_CONFIG_BOOT_MAX_IMG_SECTORS=128
   sample.net.hawkbit.manual:
     extra_configs:
       - CONFIG_HAWKBIT_MANUAL=y
diff --git a/samples/sysbuild/with_mcuboot/boards/stm32h573i_dk.overlay b/samples/sysbuild/with_mcuboot/boards/stm32h573i_dk.overlay
new file mode 100644
index 0000000000000..2e4030e522419
--- /dev/null
+++ b/samples/sysbuild/with_mcuboot/boards/stm32h573i_dk.overlay
@@ -0,0 +1,16 @@
+/*
+ * Copyright (c) 2025 STMicroelectronics
+ *
+ * SPDX-License-Identifier: Apache-2.0
+ */
+
+/*
+ * Define the device, controller and partition to be the external memory
+ * for running the application in external NOR from MCUboot
+ */
+/ {
+	chosen {
+		zephyr,flash = &mx25lm51245;
+		zephyr,flash-controller = &mx25lm51245;
+	};
+};
diff --git a/samples/sysbuild/with_mcuboot/sample.yaml b/samples/sysbuild/with_mcuboot/sample.yaml
index a2e53a4fbecb0..bdd79980ed298 100644
--- a/samples/sysbuild/with_mcuboot/sample.yaml
+++ b/samples/sysbuild/with_mcuboot/sample.yaml
@@ -17,6 +17,7 @@ tests:
       - nucleo_h7s3l8
       - nucleo_u385rg_q
       - stm32h7s78_dk
+      - stm32h573i_dk
     integration_platforms:
       - nrf52840dk/nrf52840
       - esp32_devkitc/esp32/procpu
diff --git a/soc/st/stm32/Kconfig b/soc/st/stm32/Kconfig
index b4d1e1148ae3c..06215237cac32 100644
--- a/soc/st/stm32/Kconfig
+++ b/soc/st/stm32/Kconfig
@@ -104,4 +104,12 @@ config STM32_BACKUP_PROTECTION
 	  Enabled for SoCs for which access protection to backup domain
 	  resources needs to be explicitly handled.
 
+config STM32_APP_IN_EXT_FLASH
+	bool
+	help
+	  Allows the SoC clock driver to correctly initialize the
+	  Q/O/XSPI controller clocks when the application is residing
+	  in external Flash and is chainloaded with MCUboot.
+	  Whether the app is eXecuted in Place (XiP) depends on the MCUboot mode used.
+
 endif # SOC_FAMILY_STM32
diff --git a/soc/st/stm32/Kconfig.defconfig b/soc/st/stm32/Kconfig.defconfig
index aafb321151a46..22b8d06040412 100644
--- a/soc/st/stm32/Kconfig.defconfig
+++ b/soc/st/stm32/Kconfig.defconfig
@@ -85,6 +85,9 @@ config FLASH_BASE_ADDRESS
 		if $(DT_FLASH_PARENT_IS_XSPI)
 	default $(dt_chosen_reg_addr_hex,$(DT_CHOSEN_Z_FLASH))
 
+config STM32_APP_IN_EXT_FLASH
+	default $(DT_FLASH_PARENT_IS_XSPI)
+
 # The XSPI PSRAM driver creates a SMH region with attribute SMH_REG_ATTR_EXTERNAL (2)
 # If applicable set the LTDC / VIDEO_BUFFER SMH attribute to SMH_REG_ATTR_EXTERNAL (2)
 # in order to be able to allocate from the XSPI PSRAM