diff --git a/modules/mbedtls/Kconfig.mbedtls b/modules/mbedtls/Kconfig.mbedtls
index 4a71ec4961421..13169dbf07a24 100644
--- a/modules/mbedtls/Kconfig.mbedtls
+++ b/modules/mbedtls/Kconfig.mbedtls
@@ -586,6 +586,7 @@ config MBEDTLS_PSA_CRYPTO_EXTERNAL_RNG_ALLOW_NON_CSPRNG
 config MBEDTLS_PSA_CRYPTO_C
 	bool "Platform Security Architecture cryptography API"
 	depends on !BUILD_WITH_TFM
+	depends on !NRF_IRONSIDE
 
 config MBEDTLS_USE_PSA_CRYPTO
 	bool "Use PSA APIs instead of legacy MbedTLS when possible"
@@ -597,7 +598,7 @@ config MBEDTLS_USE_PSA_CRYPTO
 config MBEDTLS_PSA_CRYPTO_CLIENT
 	bool
 	default y
-	depends on BUILD_WITH_TFM || MBEDTLS_PSA_CRYPTO_C
+	depends on BUILD_WITH_TFM || MBEDTLS_PSA_CRYPTO_C || NRF_IRONSIDE
 	select PSA_CRYPTO_CLIENT
 
 config MBEDTLS_LMS
diff --git a/subsys/secure_storage/Kconfig b/subsys/secure_storage/Kconfig
index 307cba86662d3..75158950acb8a 100644
--- a/subsys/secure_storage/Kconfig
+++ b/subsys/secure_storage/Kconfig
@@ -4,6 +4,7 @@
 menuconfig SECURE_STORAGE
 	bool "Secure storage subsystem"
 	depends on !BUILD_WITH_TFM
+	depends on !NRF_IRONSIDE
 	select MBEDTLS_PSA_CRYPTO_STORAGE_C if MBEDTLS_PSA_CRYPTO_C
 	help
 	  The secure storage subsystem provides an implementation of the PSA Secure Storage API