diff --git a/contracts/utils/ReentrancyGuard.sol b/contracts/utils/ReentrancyGuard.sol
index c156fa1cc96..6771ed0b77a 100644
--- a/contracts/utils/ReentrancyGuard.sol
+++ b/contracts/utils/ReentrancyGuard.sol
@@ -20,6 +20,10 @@ import {StorageSlot} from "./StorageSlot.sol";
  * TIP: If EIP-1153 (transient storage) is available on the chain you're deploying at,
  * consider using {ReentrancyGuardTransient} instead.
  *
+ * NOTE: {ReentrancyGuard} and {ReentrancyGuardTransient} are not interoperable. Since
+ * each tracks reentrancy state independently, a `nonReentrant` function from one will not
+ * prevent reentrant calls to a `nonReentrant` function from the other.
+ *
  * TIP: If you would like to learn more about reentrancy and alternative ways
  * to protect against it, check out our blog post
  * https://blog.openzeppelin.com/reentrancy-after-istanbul/[Reentrancy After Istanbul].
diff --git a/contracts/utils/ReentrancyGuardTransient.sol b/contracts/utils/ReentrancyGuardTransient.sol
index 273a5dcd308..67e6604d578 100644
--- a/contracts/utils/ReentrancyGuardTransient.sol
+++ b/contracts/utils/ReentrancyGuardTransient.sol
@@ -10,6 +10,10 @@ import {TransientSlot} from "./TransientSlot.sol";
  *
  * NOTE: This variant only works on networks where EIP-1153 is available.
  *
+ * NOTE: {ReentrancyGuardTransient} and {ReentrancyGuard} are not interoperable. Since
+ * each tracks reentrancy state independently, a `nonReentrant` function from one will not
+ * prevent reentrant calls to a `nonReentrant` function from the other.
+ *
  * _Available since v5.1._
  *
  * @custom:stateless