Preferred term label
iron-recycling macrophage
Synonyms (add reference(s), please)
erythrophagocytic tissue-resident macrophage (related) — DOI:10.1126/science.abo0510
SLC40A1-positive tissue-resident macrophage (related) — DOI:10.1126/science.abo0510
prenatal iron-recycling macrophage (narrow) — DOI:10.1038/s41586-024-08002-x
Definition (free text, with reference(s), please. PubMed ID format is PMID:XXXXXX)
A tissue-resident macrophage specialised in the phagocytosis of senescent erythrocytes and the recycling of iron from degraded haemoglobin, with iron export mediated by ferroportin (SLC40A1) (DOI:10.3233/TRD-170015). Identified across multiple prenatal human organs during fetal development, with highest enrichment in later gestation when immune effector gene programmes are progressively upregulated (DOI:10.1126/science.abo0510). In prenatal skin (7–17 post-conception weeks), this macrophage subset co-localises with endothelial cells in neurovascular microenvironments and specifically promotes endothelial cell chemotaxis and angiogenesis (DOI:10.1038/s41586-024-08002-x). The closest postnatal counterparts are splenic red pulp macrophages and Kupffer cells.
Parent cell type term (check the hierarchy here https://www.ebi.ac.uk/ols4/ontologies/cl)
tissue-resident macrophage (CL:0000864) — https://www.ebi.ac.uk/ols4/ontologies/cl/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FCL_0000864
Anatomical structure where the cell type is found (check Uberon for anatomical structures: https://www.ebi.ac.uk/ols4/ontologies/uberon)
Note: this is a cross-organ prenatal population, not restricted to a single tissue. The most appropriate general term is:
embryo (UBERON:0000922) — https://www.ebi.ac.uk/ols4/ontologies/uberon/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FUBERON_0000922
Specific documentation includes fetal skin, and the original cross-organ atlas reports presence across multiple fetal organs (Suo et al. 2022).
Your ORCID
[To be added by submitter]
Additional notes or concerns
This term is needed because no existing CL term captures a tissue-resident macrophage defined by ferroportin (SLC40A1)-mediated iron recycling from erythrophagocytosis operating in a prenatal developmental context. The nearest existing terms — CL:0000874 (splenic red pulp macrophage) and CL:0000091 (Kupffer cell) — both perform erythrophagocytosis and iron recycling but are each restricted to a single adult tissue (spleen or liver respectively). The atlas iron-recycling macrophage is a distinct prenatal subset found across multiple fetal organs and shares functional overlap with both postnatal types but is not equivalent to either.
Proposed logical axioms:
- subClassOf 'capable of' some 'iron ion export across plasma membrane' (GO:1903988)
[defines ferroportin/SLC40A1-mediated iron export as the core functional characteristic]
- subClassOf 'capable of' some 'heme catabolic process' (GO:0042167)
[reflects erythrophagocytosis and haemoglobin degradation upstream of iron export]
- subClassOf 'capable of part of' some 'endothelial cell chemotaxis' (GO:0035767)
[gene module analysis shows this subset specifically promotes endothelial chemotaxis in prenatal skin]
- subClassOf 'capable of part of' some 'angiogenesis' (GO:0001525)
[all four prenatal skin macrophage subsets including this one express angiogenesis gene programmes]
- subClassOf 'expresses' some 'ferroportin' (PR:000015138)
[SLC40A1/ferroportin expression is the defining molecular marker]
Key references:
- Gopee et al. (2024) — DOI:10.1038/s41586-024-08002-x — identification in prenatal skin, endothelial co-localisation, angiogenesis and chemotaxis programmes
- Suo et al. (2022) — DOI:10.1126/science.abo0510 — cross-organ prenatal definition, temporal dynamics, postnatal counterparts
- Ferreira and Gahl (2017) — DOI:10.3233/TRD-170015 — ferroportin as sole mammalian iron exporter in macrophages
- Sukhbaatar and Weichhart (2018) — DOI:10.3390/ph11040137 — macrophage erythrophagocytosis and iron homeostasis
- Recalcati et al. (2018) — DOI:10.3324/haematol.2018.197517 — macrophage ferroportin in local tissue iron provision
*Draft generated by atlas-chat from: https://github.com/Cellular-Semantics/Atlas-chat/blob/fetal_skin_atlas/projects/fetal_skin_atlas/reports/Iron-recycling_macrophage.md
Preferred term label
iron-recycling macrophage
Synonyms (add reference(s), please)
erythrophagocytic tissue-resident macrophage (related) — DOI:10.1126/science.abo0510
SLC40A1-positive tissue-resident macrophage (related) — DOI:10.1126/science.abo0510
prenatal iron-recycling macrophage (narrow) — DOI:10.1038/s41586-024-08002-x
Definition (free text, with reference(s), please. PubMed ID format is PMID:XXXXXX)
A tissue-resident macrophage specialised in the phagocytosis of senescent erythrocytes and the recycling of iron from degraded haemoglobin, with iron export mediated by ferroportin (SLC40A1) (DOI:10.3233/TRD-170015). Identified across multiple prenatal human organs during fetal development, with highest enrichment in later gestation when immune effector gene programmes are progressively upregulated (DOI:10.1126/science.abo0510). In prenatal skin (7–17 post-conception weeks), this macrophage subset co-localises with endothelial cells in neurovascular microenvironments and specifically promotes endothelial cell chemotaxis and angiogenesis (DOI:10.1038/s41586-024-08002-x). The closest postnatal counterparts are splenic red pulp macrophages and Kupffer cells.
Parent cell type term (check the hierarchy here https://www.ebi.ac.uk/ols4/ontologies/cl)
tissue-resident macrophage (CL:0000864) — https://www.ebi.ac.uk/ols4/ontologies/cl/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FCL_0000864
Anatomical structure where the cell type is found (check Uberon for anatomical structures: https://www.ebi.ac.uk/ols4/ontologies/uberon)
Note: this is a cross-organ prenatal population, not restricted to a single tissue. The most appropriate general term is:
embryo (UBERON:0000922) — https://www.ebi.ac.uk/ols4/ontologies/uberon/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FUBERON_0000922
Specific documentation includes fetal skin, and the original cross-organ atlas reports presence across multiple fetal organs (Suo et al. 2022).
Your ORCID
[To be added by submitter]
Additional notes or concerns
This term is needed because no existing CL term captures a tissue-resident macrophage defined by ferroportin (SLC40A1)-mediated iron recycling from erythrophagocytosis operating in a prenatal developmental context. The nearest existing terms — CL:0000874 (splenic red pulp macrophage) and CL:0000091 (Kupffer cell) — both perform erythrophagocytosis and iron recycling but are each restricted to a single adult tissue (spleen or liver respectively). The atlas iron-recycling macrophage is a distinct prenatal subset found across multiple fetal organs and shares functional overlap with both postnatal types but is not equivalent to either.
Proposed logical axioms:
[defines ferroportin/SLC40A1-mediated iron export as the core functional characteristic]
[reflects erythrophagocytosis and haemoglobin degradation upstream of iron export]
[gene module analysis shows this subset specifically promotes endothelial chemotaxis in prenatal skin]
[all four prenatal skin macrophage subsets including this one express angiogenesis gene programmes]
[SLC40A1/ferroportin expression is the defining molecular marker]
Key references:
*Draft generated by atlas-chat from: https://github.com/Cellular-Semantics/Atlas-chat/blob/fetal_skin_atlas/projects/fetal_skin_atlas/reports/Iron-recycling_macrophage.md