Closed-Loop Sensorimotor Integration experiment in mice and monkeys

[ABastos]

If we implement the sensory-motor paradigm in monkeys with a joystick coupled to an avatar, will this be a sufficient comparison to the mouse data?

Which specific oddball types should be included? Visual flow disconnected from joystick/running speed, continuing visual flow while stopping running/joystick and the inverse, stopping visual flow while continuing running/joystick movement.

[jeromelecoq]

I think this is a very good question. I can't think of any other simple ways to do this.
If the monkey joystick control forward or backward motion of the drifting grating that would make sense. I guess we would have to make sure the control is rewarded to encourage engagement.
This could be similar to this paper : https://www.nature.com/articles/s41586-024-07851-w
where the mouse was rewarded for traveling certain distances and on the way the mismatches where introduced.

To be honest, I might argue that the very valuable assets in primate might be all of the other session types (3 out of 4). I think it would be reasonable to focus on purely visual tasks.

Mouse sensory-motor coupling is deeply innate and engrained. The joystick might be a much more naive task so I am not sure the results would directly port over. It would certainly be a lot of work.

I am curious what other people think?