Please use this forum to introduce yourself!

[jeromelecoq]

If you are interested in joining this effort, please feel free to says so on this forum:

• Just state who you are and where you work.
• Explain what contributions you are interested in making

We will do our best to guide you through.

[Sarruedi]

Hi everyone, I’m Sarah Ruediger, a junior group leader at University College London. My lab is interested in how brain circuits support the learning and performance of visually guided actions. We look forward to collaborating — both by helping to analyze shared datasets and by contributing data from the lab that can complement the work being done at the Allen Institute. It is exciting to be part of a global community with shared interests and I really look forward to meeting and working with y'all.

[rcpeene]

Howdy all, I'm Carter. I'm an analyst at the Allen Institute and have been working with Jerome to collect and process and package our slap2 data into NWB. Let me know if there's any questions or suggestions for the data.

[kma-code]

Hi, I'm Kevin Max, Postdoc in comp neuro with Kenji Doya at OIST, Japan.

I'm in the "backpropagation and the brain" camp, studying network models of cortex with the aim of including as much biological detail as needed, while maintaining an understanding how such networks learn to solve complex tasks.

Because "backprop and the brain" is controversial, I want to test it against competing theories like dendritic Predictive Coding using experimental data. I think this community is interested in this as well, see e.g. a recent paper by H. Choi et al.

We are also running 2p-CA behavioral experiments with mice here at OIST. Happy to contribute and share data as it gets available.

I will not be able to attend weekly meetings due to the time shift, but please hit me up if you'd like to discuss.

[ido4848]

Hey everyone,
I'm Ido Aizenbud, a PhD Candidate in Computational Neuroscience with Idan Segev and Mickey London, The Hebrew University of Jerusalem, Israel.

My research focuses on the theoretical and computational aspects of dendritic computation, combining detailed biophysical neuron models with machine learning frameworks. I aim to characterize not only the input–output complexity of single neurons, but also their learning capabilities, the functional space they can realize, and how input encoding influences these capacities.

I’m particularly interested in collaborating on the SLAP2 dataset to dissect the types of inputs dendrites receive across spatial locations, and to explore how this organization contributes to single-neuron computation. I look forward to exchanging ideas and building collaborations within this community.

[KasparP]

Hi Ido! Welcome. I would be excited for you to participate. Happy to discuss details here on what to get started on and how best to make progress. Most of the current SLAP2 recordings have only mediocre or absent calcium signals for the output; this will improve a lot in coming months. I recommend focusing on the glutamate data, thinking about the experiments themselves (which there is still some small opportunity to expand or change), and trying out some analyses.

[KasparP]

My introduction: I'm a Scientist at the Allen Institute, my team is performing SLAP2 measurements and contributing data to the project. We are interested in how dendritic computations may (or may not) contribute to predictive processing and how patterns of input to individual neurons change across contexts.

[ido4848]

Thank you, @KasparP, and sorry for the delay.

What is the current state of data (i.e., do we now have some experiments with both glutamate and calcium?)
And what is the state-of-the-art analysis notebook I could build upon?

[jeromelecoq]

Hi Ido,
We currently have a few session with calcium and glutamate but we know that glutamate typically bleach out quickly.
It would be interested for someone to take a closer look at that. I believe some of the recent sessions have the calcium channel as well as the glutamate channel.

Some others here might have been looking at this but I have not seen recent plots on it.
I am curious whether @Dedalus9 or @lrudelt have more thoughts there.

[ido4848]

Thanks @jeromelecoq.
I'm indeed interested in taking a closer look at that.
I'll try to find a session with both calcium and glutamate.

[kshtjkumar]

Hi everyone, I’m Kshitij Kumar from IIT Kanpur. My work focuses on neuroscience and predictive processing, and I’m interested in contributing to data analysis and modeling for SLAP2 and related projects.

[jeromelecoq]

Hi Kshitij, The best way to get started is to start looking at some of our latest data.

We do have some recent SLAP2 data on the DANDI repository. Among the open questions are how the tuning properties are distributed across space.
For example, we have not analyzed receptive field location for every synapse. I would be curious to see if those receptive fields are systematically different between apical and proximal dendrites.

Hi everyone, I’m Kshitij Kumar from IIT Kanpur. My work focuses on neuroscience and predictive processing, and I’m interested in contributing to data analysis and modeling for SLAP2 and related projects.